Prospective Evaluation of a Shortened Regimen of Treatment for Acute Osteomyelitis and Septic Arthritis in Children

Jagodzinski, N.A.; Kanwar, Rajeev; Graham, Kerr; Bache, C. E.

doi:10.1097/bpo.0b013e3181ab472d

Cited by 173 publications

(123 citation statements)

References 38 publications

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“…Peltola et al propose shorter course of treatment in pediatric patients > 3 months old, but only few reports is written in newborn patients. 21,22 Complications encountered during prolonged parenteral antibiotic treatment in children with acute OA infection are related, such as antimicrobial drug reactions and catheter related infections. 23 Sequential parenteral-oral therapy may be used with close follow-up.…”

Section: Discussionmentioning

confidence: 99%

Osteoarthritis in the neonate: risk factors and outcome

Berberián¹,

Firpo²,

Soto³

et al. 2010

Braz J Infect Dis

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We declare no confl ict of interest. ABSTRACT Objectives:The aim of this study was to identify the clinical, radiological, and bacteriological features, risk factors, and outcome of neonates with bone and joint infections. Study design: Observational, retrospective, and analytical study of 77 patients less than 2 months of age, admitted to a tertiary neonatal intensive care unit (NICU) with the diagnosis of bone or joint infection, based on clinical, radiological, and microbiological criteria. Results: Seventy-seven patients with 99 acute osteoarthritis foci in a 16 year period were included in the study. Risk factors for infection could be identifi ed in 69% of the patients. The hip was the most frequent. Staphylococcus aureus was the main isolated microorganism. Twenty-nine infants (38%) had sequelae. Hip involvement, culture positive, and Staphylococcus aureus isolation were risk factors associated with sequelae. Conclusion: Osteoarticular infection is unusual in the neonate; however it is associated with an elevated incidence of sequelae. This mandates for a high degree of suspicion to diagnose this potentially disabling entity.

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Section: Discussionmentioning

confidence: 99%

Osteoarthritis in the neonate: risk factors and outcome

Berberián¹,

Firpo²,

Soto³

et al. 2010

Braz J Infect Dis

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“…therapy and 86% converting to oral therapy after 5 days. All 70 children had good outcomes at 1 year of follow-up (514). Similarly, Peltola et al switched 131 patients to oral therapy after a median of 3 to 4 days of i.v.…”

Section: Osteoarticular Infections In Childrenmentioning

confidence: 95%

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

et al. 2015

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SUMMARY Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.

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“…As shown in Table 2, the duration of i.v. administration has shortened elsewhere as well [57][58][59]. Serum antimicrobial assays before switch to the oral route were once recommended [54] A c c e p t e d M a n u s c r i p t 13 are no longer used.…”

Section: Intravenous Versus Oral Administrationmentioning

confidence: 99%

Antibiotic treatment for acute haematogenous osteomyelitis of childhood: Moving towards shorter courses and oral administration

Pääkkönen¹,

Peltola²

2011

International Journal of Antimicrobial Agents

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Prospective Evaluation of a Shortened Regimen of Treatment for Acute Osteomyelitis and Septic Arthritis in Children

Abstract: We have found that a shortened course of intravenous and oral antibiotic therapy is effective in the management of acute uncomplicated bone and joint sepsis in children.

Cited by 173 publications

References 38 publications

Osteoarthritis in the neonate: risk factors and outcome

Osteoarthritis in the neonate: risk factors and outcome

Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

Antibiotic treatment for acute haematogenous osteomyelitis of childhood: Moving towards shorter courses and oral administration

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