Prospective controlled study of home and hospital therapy of cystic fibrosis pulmonary disease

Donati, Mary Alice; Guenette, Ginny; Auerbach, H S

doi:10.1016/s0022-3476(87)80337-2

Cited by 92 publications

(46 citation statements)

References 13 publications

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“…Recent studies have been published that demonstrate the effectiveness of OPAT for patients with osteomyelitis [131,137,139,140] and children with complicated appendicitis [130]. Studies of pneumonia in patients with cystic fibrosis indicate at least comparable outcomes and higher patient satisfaction with OPAT than hospital care [7,17,18,[141][142][143][144][145]. Some studies show earlier return to normal function if hospital admission can be avoided [15,146].…”

Section: Opat Outcomes and Patient Safetymentioning

confidence: 99%

“…Some problems are unique to children, such as Munchausen syndrome by proxy. Literature on OPAT specific to children is not as extensive as literature on the outpatient treatment of adults, but a number of articles on pediatric therapy and complications have been written for communityacquired infections, meningitis, fever and neutropenia, and cystic fibrosis [130,141,145,[152][153][154][155][156][157][158][159][160][161][162][163][164][165][166][167][168].…”

Section: Considerations For Pediatric Patientsmentioning

confidence: 99%

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Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy

Tice

Rehm

Dalovisio

et al. 2004

Journal of Infusion Nursing

124

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EXECUTIVE SUMMARYThese guidelines were formulated to assist physicians and other health care professionals with various aspects of the administration of outpatient parenteral antimicrobial therapy (OPAT). Although there are many reassuring retrospective studies on the efficacy and safety of OPAT, few prospective studies have been conducted to compare the risks and outcomes for patients who receive treatment as outpatients rather than as inpatients. Because truly evidence-based studies are lacking, the present guidelines are formulated from the collective experience of the committee members and advisors from related organizations.Important aspects of OPAT are described in the text and tables and include the following:1. The literature supports the effectiveness of OPAT for a wide variety of infections (table 1 and the Appendix).2. A thorough assessment of the patient's general medical condition, the infectious process, and the home situation is necessary before starting therapy (table 2) 3. Prescribing physicians should be aware of a number of aspects of OPAT which distinguish it from

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Section: Opat Outcomes and Patient Safetymentioning

confidence: 99%

Section: Considerations For Pediatric Patientsmentioning

confidence: 99%

Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy

Tice

Rehm

Dalovisio

et al. 2004

Journal of Infusion Nursing

124

View full text Add to dashboard Cite

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“…Clinical improvement with home therapy in appropriately selected patients has been well-demonstrated [15][16][17][18]. However, there is only one published controlled comparison of outcome in home versus hospital therapy in cystic fibrosis [19]. In this study, FVC was found to improve to a significantly greater extent in hospital, as was arterial oxygen tension (PaO 2 ), but not the other measured variables, which included FEV 1 .…”

Section: Discussionmentioning

confidence: 62%

Home versus hospital intravenous antibiotic therapy in the treatment of young adults with cystic fibrosis

Pond

Newport²,

Joanes³

et al. 1994

Eur Respir J

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H Ho om me e v ve er rs su us s h ho os sp pi it ta al l i in nt tr ra av ve en no ou us s a an nt ti ib bi io ot ti ic c t th he er ra ap py y i in n t th he e t tr re ea at tm me en nt t o of f y yo ou un ng g a ad du ul lt ts s w wi it th h c cy ys st ti ic c f fi ib br ro os si is s The case records of all patients attending the Leeds adult cystic fibrosis clinic were reviewed to identify those who had received home intravenous antibiotic treatment. All home treatments undertaken were included. For each home treatment, the temporally closest hospital treatment for that patient was then selected for comparison and the changes with treatment in peak expiratory flow rate (PEFR), forced vital capacity (FVC), forced expiratory volume in one second (FEV 1 ), Creactive protein (CRP), plasma viscosity, total white cell count, absolute neutrophil count, total immunoglobulin G (IgG) concentration, chest X-ray score (Northern), clinical score, Shwachman-Kulczyki score and weight were analysed for differences between home treatment and hospital treatment. Fifty one paired home/hospital treatments in 25 patients were compared.The improvement in total white cell count was found to be significantly greater in the hospital group, but the difference was very small. The improvements in absolute neutrophil count, and all the other measured variables, were the same in the two groups.Treatment of exacerbations of cystic fibrosis at home or in hospital is, thus, equally effective given proper patient selection and adequate monitoring of the response to treatment.

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“…treatment, and in 1982 developed it into home management, with the aim of improving quality of life. DONATI et al [9] demonstrated, in a prospective controlled study, that both i.v. hospital treatment and i.v.…”

Section: Effectivenessmentioning

confidence: 98%

“…Studies from Sweden [1], the UK [8], The Netherlands [10], France [9], and the USA [25], evaluating this subject from different backgrounds, all indicate that home treatment provides substantial economic savings.…”

Section: Cost Benefitsmentioning

confidence: 99%

Home care in cystic fibrosis patients

Aalderen¹,

Mannes²,

Bosma³

et al. 1995

Eur Respir J

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Intravenous antibiotics and enteral tube feeding at home for the treatment of pulmonary exacerbations and underweight condition in cystic fibrosis (CF) patients have become tools that are used in many cystic fibrosis centres. The experience with home care programmes from different countries is quite conclusive. If the necessary preparations are made, such as training of staff and patients, and financial support is arranged, home care is easy to put into practice. Optimal patient compliance is also necessary.Home care is as effective as hospital treatment for selected patients, and less expensive. Experience has increased during many treatment periods in different cystic fibrosis centres, and only a few adverse events have been recorded, indicating that home care is safe. However, the most important gain for cystic fibrosis patients is the reduction of hospital admission time, which means a definite improvement in the quality of life.

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Prospective controlled study of home and hospital therapy of cystic fibrosis pulmonary disease

Cited by 92 publications

References 13 publications

Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy

Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy

Home versus hospital intravenous antibiotic therapy in the treatment of young adults with cystic fibrosis

Home care in cystic fibrosis patients

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