Prospective Comparison of Dual Wavelength Long-Pulsed 755-nm Alexandrite/1,064-nm Neodymium:Yttrium-Aluminum-Garnet Laser versus 585-nm Pulsed Dye Laser Treatment for Rosacea

Seo, Hyun-Min; Kim, Jung-In; Kim, Hansaem; Choi, Young‐Jun; Kim, Won‐Serk

doi:10.5021/ad.2016.28.5.607

Cited by 18 publications

(22 citation statements)

References 22 publications

(29 reference statements)

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“…Additionally, biophysical tools are probe‐related; they only cover a small facial area, questioning representativeness of the entire face. Placing the device on the same area of interest in follow‐up visits is therefore challenging . Computer‐aided image analysis does not impose these problems as whole face erythema is mapped.…”

Section: Discussionmentioning

confidence: 99%

“…Placing the device on the same area of interest in follow-up visits is therefore challenging. 64,76,113 Computer-aided image analysis does not impose these problems as whole face erythema is mapped. Moreover, redness values are obtained without performing skin contact.…”

Section: Discussionmentioning

confidence: 99%

“…[99][100][101][102] Erythema Twenty-two studies assessed monitoring of facial skin erythema by spectrometry. 48,64,68,[78][79][80]82,83,90,96,[103][104][105][106][107][108][109][110][111][112][113][114] Three spectrometric methods were applied; 28 reflectance spectrophotometry, 3,64,68,[78][79][80]82,96,104,[106][107][108]110,111,113 tristimulus colorimetry 83,90,103,109,112 and diffuse reflectance spectroscopy. 105,114 One study used an optical densitometer.…”

Section: Stratum Corneum Hydrationmentioning

confidence: 99%

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Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

et al. 2019

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Summary Background Rosacea assessment and therapy monitoring can be challenging to standardize, as most clinical evaluation systems are prone to interobserver variability and not always validated. Therefore, objective, reliable and preferably noninvasive measurement tools are needed. Objectives To give insight into available noninvasive imaging techniques and biophysical methods in rosacea by performing a systematic review. Methods PubMed, Embase, Cochrane and Web of Science databases were searched until 1 September 2018 in accordance with PRISMA guidelines, to identify studies providing original data about objective noninvasive imaging and/or biophysical skin measurement techniques for diagnosis, assessing severity or therapy monitoring of adult patients with cutaneous facial rosacea. Risk of bias of included articles was assessed with the Cochrane Risk of Bias tool, Quality in Prognosis Studies tool, and the Newcastle–Ottawa Scale. Results A total of 78 studies were included, describing 14 imaging and biophysical methods. Widespread information about (sub)surface cutaneous morphology and functionality was obtained. Methodological study quality was relatively low and interstudy outcome variability was large. Several tools show promising value in research settings: for treatment follow‐up Demodex mites are countable with reflectance confocal microscopy, spectrometry can quantify erythema, and rosacea severity could be objectified with skin hydration‐ and transepidermal water loss measurements. Conclusions This systematic review describes the spectrum of noninvasive imaging and biophysical methods in rosacea assessment, giving multifaceted information about structure and properties of rosacea skin, especially useful for research purposes. Larger studies with good methodological quality are needed to create validated protocols for further implementation into research. What's already known about this topic? Rosacea is a chronic inflammatory skin disease with a variety of clinical manifestations. Most clinical evaluation systems are subjective, not always validated, and subsurface skin processes remain unnoticed. Currently, different types of noninvasive measurement tools are available for rosacea assessment and therapy monitoring, but a comprehensive overview is lacking. What does this study add? Seventy‐eight publications were included, describing 14 imaging and biophysical tools, providing a wide range of information about rosacea skin morphology and functionality. Reflectance confocal microscopy and spectrometry are especially promising in therapy monitoring and skin barrier measurements for rosacea severity assessment. Larger studies with better methodological quality are needed to create validated protocols for implementation into research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Stratum Corneum Hydrationmentioning

confidence: 99%

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Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

et al. 2019

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“…6 The PDL may cause marked vessel disruption and purpura which persists for 10-14 days. 14,15 We report a lower number of adverse events following treatment with the fractional 532-nm KTP laser than with the 595-nm PDL. The fractional 532-nm KTP laser was less painful according to subjective selfassessment, and 12 of 19 participants (63%) preferred the fractional 532-nm KTP diode laser to the 595-nm PDL for this reason.…”

Section: Discussionmentioning

confidence: 81%

“…However, when treating more superficial lesions, there was no difference between use of a 532‐nm KTP and a 595‐nm PDL . The PDL may cause marked vessel disruption and purpura which persists for 10‐14 days . We report a lower number of adverse events following treatment with the fractional 532‐nm KTP laser than with the 595‐nm PDL.…”

Section: Discussionmentioning

confidence: 99%

Fractional 532‐nm KTP diode laser and 595‐nm pulsed dye laser in treatment of facial telangiectatic erythema

Nam

Kim

Hong

et al. 2018

J of Cosmetic Dermatology

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Use of Patient-Reported Outcomes in Acne Vulgaris and Rosacea Clinical Trials From 2011 to 2021

Miller

Tong

et al. 2022

JAMA Dermatol

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ImportanceAcne and rosacea have substantial implications for quality of life, and it is therefore important to ensure the patient’s voice is being captured in pivotal randomized clinical trials (RCTs). Although patient-reported outcome measures (PROMs) are a valuable tool to capture the patient perspective, little is known about use of PROMs in RCTs on acne and rosacea.ObjectiveTo characterize the use of PROMs in RCTs on acne and rosacea.Evidence ReviewA systematic literature search was conducted using the search terms acne vulgaris and rosacea in the following databases: MEDLINE through PubMed, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews. A modified search hedge for RCTs from the McGill Library was applied. All phase 2, 3, and 4 RCTs published between December 31, 2011, through December 31, 2021, that evaluated the efficacy and safety of therapies for acne and rosacea vs any comparator were eligible for inclusion.FindingsA total of 2461 publications describing RCTs were identified, of which 206 RCTs met the inclusion criteria (163 trials [79%] on acne and 43 [21%] on rosacea). At least 1 PROM was used in 53% of trials (110) included; PROM use was more common in rosacea RCTs (67% [n = 29]) compared with acne RCTs (50% [n = 81]). At least 1 dermatology-specific (13% [n = 27]) or disease-specific (14% [n = 28]) PROM was included in the RCTs analyzed. Only 7% of trials (14) included a PROM as a primary outcome measure. There was no statistically significant increase in PROM inclusion over the study period (11 of 21 trials in 2011 vs 5 of 12 trials in 2021).Conclusions and RelevanceIn this systematic review, PROMs were included in approximately one-half of acne and rosacea RCTs performed over the study period. In addition, PROMs were rarely used as a primary outcome measure, and inclusion of PROMs has not increased substantially over the past 10 years. Increasing use of PROMs in RCTs can ensure that the patient’s perspective is captured during the development of new treatments for acne and rosacea.

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Prospective Comparison of Dual Wavelength Long-Pulsed 755-nm Alexandrite/1,064-nm Neodymium:Yttrium-Aluminum-Garnet Laser versus 585-nm Pulsed Dye Laser Treatment for Rosacea

Cited by 18 publications

References 22 publications

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

Noninvasive objective skin measurement methods for rosacea assessment: a systematic review

Fractional 532‐nm KTP diode laser and 595‐nm pulsed dye laser in treatment of facial telangiectatic erythema

Use of Patient-Reported Outcomes in Acne Vulgaris and Rosacea Clinical Trials From 2011 to 2021

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