Introduction: The Visual Prostate Symptom Score (VPSS) is an image-based interpretation of the International Prostate Symptom Score (IPSS) intended to quantify frequency, nocturia, weak stream, and quality of life (QoL) in a literacy-independent manner. Methods: Ugandan men presenting with lower urinary tract symptoms (LUTS) to a rural clinic completed VPSS and IPSS independently and then with assistance. They verbally interpreted VPSS images, rated question usefulness, and suggested improvements. Responses between word-based and image-based measures were compared (Student's T, Fisher's exact, and Spearman's correlation tests). Results: 132 scores from 33 men (mean age: 61 years, range 28-93; education: no schooling 20%, grades 1-4 62%, 5-7 9%, 8-12 9%). Correlation between IPSS and VPSS scores was positive (r= 0.70), as it was between the individual irritative, obstructive, and QoL questions. Independent of education, the weak stream image was best recognized. Likert scale measures indicated this was the most useful image, followed by daytime frequency. Nocturia and QoL images were rated as less clear, with explanation required before most understood that QoL facial expression images reflected overall LUTS impact. Improvements suggested included: increased image size for frequency and nocturia pictograms, increased black/white contrast for nocturia, and addition of an image to allow reporting of urgency.