Prospective comparative evaluation of quantitative-elastosonography (Q-elastography) and contrast-enhanced ultrasound for the evaluation of thyroid nodules: Preliminary experience

Cantisani, Vito; Consorti, Fabrizio; Guerrisi, Antonino; Guerrisi, I.; Ricci, Paolo; Segni, Mattia Di; Mancuso, Ester; Scardella, Laura; Milazzo, Francesca; Dambrosio, F; Antonaci, A

doi:10.1016/j.ejrad.2013.07.005

Cited by 68 publications

(61 citation statements)

References 34 publications

(66 reference statements)

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“…According to our data, the most reliable symptom of benignity was the rim-like enhancement presenting 94% sensitivity, 61% specificity, and 77% accuracy. In accordance with our results, also in studies by Zhang et al (2010), Cantisani et al (2013) and Ma et al (2014) rim-like enhancement is specific to benign nodules. Results yielded by Zhang et al (2010) showed 94.1% specificity, 83.0% sensitivity.…”

Section: Discussionsupporting

confidence: 93%

“…and 88.5% accuracy. Cantisani et al evaluated this finding in conjunction with other features and concluded that the specificity of CEUS in detecting of malignant nodules was 91% and sensitivity -79% (Cantisani et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The results are ambiguous and sometimes contradictory. The diagnostic value of CEUS has been analysed in only very few studies (Ferrari et al, 2008;Zhang et al, 2010;Nemec et al, 2012;Cantisani et al, 2013;Giusti et al, 2013;Deng et al, 2014;Ma et al, 2014), yielding variable results; the sensitivity varies between 68-100% and specificity -between 67-594%.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Value of Contrast-Enhanced Ultrasound Evaluation of Malignant and Benign Solitary Thyroid Nodules

Prieditis

Radziņa

Štrumfa

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic Value of Contrast-Enhanced Ultrasound Evaluation of Malignant and Benign Solitary Thyroid Nodules

Prieditis

Radziņa

Štrumfa

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…RTE may be useful in the diagnosis of thyroid nodules to exclude papillary thyroid cancer, but not follicular carcinoma; CEUS shows no improvement in the characterization of thyroid nodules (16). A previous study also revealed that Q-elastography is a better tool in differentiating the underlying nature of thyroid nodules compared with CEUS (27); however, a combination of CEUS and RTE in the differentiation of benign and malignant thyroid nodules requires to be further evaluated.…”

Section: Introductionmentioning

confidence: 97%

Contrast-enhanced ultrasound and real-time elastography in the differential diagnosis of malignant and benign thyroid nodules

Xin

Liu

Jia

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The diagnostic value of contrast-enhanced ultrasound (CEUS) or real-time elastography (RTE) alone, as well as a combination of CEUS and RTE, in distinguishing benign from malignant thyroid nodules was investigated. Between August 2012 and June 2014, a total of 97 consecutive patients (50 male and 47 female patients; mean age, 48.6±12.4; age range, 27-70 years) with thyroid nodules referred for surgical treatment were examined by CEUS and RTE. The final diagnosis was obtained based on histological findings. Image analysis of the CEUS and RTE scans was performed. Considering the postoperative pathological results as the golden standard, a receiver operating characteristic (ROC) curve was constructed. Subsequently, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CEUS alone, RTE alone and CEUS + RTE combination were calculated. Pathological examination showed 66 papillary carcinomas and 43 benign lesions, including 21 adenomas and 22 nodular goiters. The sensitivity, specificity, PPV, NPV and accuracy of CEUS were 81.82, 90.70, 93.10, 90.70 and 85.32%, respectively. In the case of RTE, the sensitivity, specificity, PPV, NPV and accuracy were 80.30, 88.37, 91.38, 88.37 and 83.49%, respectively. Furthermore, the combination of CEUS + RTE had a sensitivity of 95.45%, specificity of 95.35%, PPV of 96.92%, NPV of 95.35% and accuracy of 95.41%. Therefore, the CEUS + RTE combination showed a significantly higher sensitivity and specificity compared with CEUS or RTE alone (all P<0.05). Based on ROC analysis, the area under the curve (AUC) for CEUS, RTE and CEUS + RTE combination was 0.883, 0.863 and 0.959, respectively. The AUC of RTE alone was significantly lower compared with that of the CEUS + RTE combination. In conclusion, our results demonstrate that CEUS + RTE combination significantly increases the diagnostic performance for differential diagnosis of malignant and benign thyroid nodules compared with CEUS or RTE alone.

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“…Some authors reported that hypoenhancement is the most accurate US feature of malignancy on CEUS with high sensitivity, specificity and accuracy 82%, 85%, and 84%, respectively [23][24][25][26][27]. Three recent meta-analyses reported high-pooled accuracy of CEUS in diagnosing benign from malignant nodules with sensitivity, specificity, and positive and negative LR ranging 0.85-0.88, 0.87-0.90, 5.8-8.6 and 0.15-19 respectively [27][28][29].…”

Section: Conventional B-mode Ultrasoundmentioning

confidence: 99%

Thyroid Ultrasound: State of the Art. Part 2 – Focal Thyroid Lesions

et al. 2017

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Accurate differentiation of focal thyroid nodules (FTL) and thyroid abnormalities is pivotal for proper diagnostic and therapeutic work-up. In these two part articles, the role of ultrasound techniques in the characterization of FTL and evaluation of diffuse thyroid diseases is described to expand on the recently published World Federation in Ultrasound and Medicine (WFUMB) thyroid elastography guidelines and review how this guideline fits into a complete thyroid ultrasound exam.

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Prospective comparative evaluation of quantitative-elastosonography (Q-elastography) and contrast-enhanced ultrasound for the evaluation of thyroid nodules: Preliminary experience

Cited by 68 publications

References 34 publications

Diagnostic Value of Contrast-Enhanced Ultrasound Evaluation of Malignant and Benign Solitary Thyroid Nodules

Diagnostic Value of Contrast-Enhanced Ultrasound Evaluation of Malignant and Benign Solitary Thyroid Nodules

Contrast-enhanced ultrasound and real-time elastography in the differential diagnosis of malignant and benign thyroid nodules

Thyroid Ultrasound: State of the Art. Part 2 – Focal Thyroid Lesions

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