Prospective Cohort Study of Pre- and Postdiagnosis Obesity and Endometrial Cancer Survival

Kokts-Porietis, Renée L; McNeil, Jessica; Morielli, Andria R.; Cook, Linda S.; Courneya, Kerry S.; Friedenreich, Christine M.

doi:10.1093/jnci/djab197

Cited by 12 publications

(10 citation statements)

References 34 publications

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“…According to present knowledge, it has been proven that overweight and obesity are often associated not only with reproductive health disorders, but also with the formation of oncological diseases [7,10,14]. We analyzed the ultrasound data of the pelvic organs in our patients and found that endometrial hyperplasia was recorded in 52 (57.7%) patients with overweight and obese, and 19 (36.7%) cases were against the background of hyperestrogenemia, which may serve as a risk factor for the RQFRSDWKRORJ\ LQ WKH IXWXUH 2YHUZHLJKW DQGRU obese patients are characterized by various dyslipidemias (DLP), which are predictors of a number of cardiovascular diseases (hypertension, atherosclerosis, etc.).…”

Section: Results and Discussion Of The Studymentioning

confidence: 99%

Comorbid pathology issues in pediatric gynecology

Bagatska¹,

Podolsky²

2022

MPU

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The problems of diagnosis, therapeutic tactics and medical prognosis in comorbid, polymorbid pathology stand out among the most actual problems of modern health care. Purpose - to study the frequency and nature of comorbid conditions in patients with pubertal abnormal uterine bleeding (PAUB). Materials and methods. The study included 342 girls aged 11-17 suffering from PAUB. All patients were examined by a multidisciplinary team of doctors. Results. It has been shown that menstrual irregularities are combined with other somatic, mental and endocrine pathologies in the vast majority of patients. Only 9.6% of the patients examined had no concomitant pathologies. More than half of girls have a combination of more than three comorbidities. The first three ranks are occupied by endocrine, mental and digestive system disorders. More than a third of patients with endocrine disorders had deviations in terms of body weight - overweight and obesity, which is much more often accompanied by changes in carbohydrate and lipid metabolism. In patients with mental disorders astheno-neurotic syndrome and vegetative-vascular dystonia syndrome prevailed. Functional disorders of the biliary tract were mainly recorded among the disorders of the digestive system, about 18% of girls suffered from gastritis, cholecystitis. The presence of comorbid pathology reduced the effectiveness of non-hormonal therapy by 1.5 times and increased the number of relapses by 3.5-4 times. The effectiveness of non-hormonal therapy was 81.8% on the absence of concomitant pathology; relapses were recorded only in 16.7%. Conclusions. Comorbid pathologies in patients with PAUB aggravate the severity of the girl’s condition, reduces adaptive capabilities, adversely affects the effectiveness of non-hormonal therapy, contributes to the recurrence of the disease and is a risk factor for the development of serious metabolic, endocrine and cardiovascular diseases in the future. The category of patients with concomitant pathology requires a special examination algorithm and the appointment of an adequate therapeutic intervention, taking into account all the identified nosological forms and drug compatibility. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

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Section: Results and Discussion Of The Studymentioning

confidence: 99%

Comorbid pathology issues in pediatric gynecology

Bagatska¹,

Podolsky²

2022

MPU

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“…Although distant metastasis is exceptionally uncommon in EC, our study showed that its incidence has increased from 2010 to 2017, especially in the period during 2016-2017. It is speculated that the reasons for this increase mainly include the prevalence of obesity, 17,18 the improvements of postmenopausal screening techniques, 19 and the influence of reproductive factors. 20,21 Furthermore, this study showed that lung was the most frequent organ in metastasis and that solitary pulmonary metastasis accounted for 57.7% of all distant pulmonary metastases, which was in accordance with the report by Mao et al 5 Researchers suspect that metastatic tumor cells may infiltrate blood vessels and facilitate the development of pulmonary metastases via the iliac veins, 22 but this has not been confirmed.…”

Section: Discussionmentioning

confidence: 99%

Incidence, risk factors, and a prognostic nomogram for distant metastasis in endometrial cancer: A SEER‐based study

Zheng,

Jiang,

et al. 2023

Intl J Gynecology & Obste

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ObjectiveTo evaluate the metastatic pattern, identify the risk factors, and establish a nomogram for predicting prognosis of endometrial cancer (EC) with distant metastasis.MethodsA retrospective cohort study of women diagnosed with EC was conducted according to the Surveillance, Epidemiology, and End Results (SEER) database during 2010–2017. Multivariate logistic analysis and Cox analysis were performed to identify the risk factors in promoting distant metastasis and predictors associated with overall survival (OS) in this particular subpopulation. A nomogram was then constructed and validated by the concordance index (C‐index), the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analysis.ResultsA total of 2799 cases of distant metastasis in EC patients were identified, with an overall incidence rate of 3.74% from 2010 to 2017. Black race, unmarried status, non‐endometrioid histologic types, and grade IV were significant risk factors for distant metastasis in EC patients. Meanwhile, race, histology, grade, metastasis status, surgery, lymphadenectomy, and chemotherapy were identified as independent prognostic factors for OS. A nomogram to predict 1‐, 3‐, and 5‐year OS was established, and presented favorable accuracy and clinical applicability. Patients were further divided into high‐ and low‐risk groups according to the model.ConclusionThe nomogram was developed as a highly accurate, individualized tool to better predict the prognosis of EC patients with distant metastasis, which would help clinicians to identify high‐risk patients, and adjust and tailor their treatment strategies.

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“…This is supported by previous reports from the Alberta Endometrial Cancer Cohort Study in which measures of obesity were associated with reduced survival. 35 , 36 Moreover, metabolic syndrome was associated with worse disease‐free and overall survival in endometrial cancer survivors. 35 …”

Section: Discussionmentioning

confidence: 99%