Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review

Schoetzau, Angela; Gehring, Ulrike; Wichmann, Heinz‐Erich

doi:10.1007/pl00008442

Cited by 25 publications

(23 citation statements)

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“…The value of hypo-allergic diets to mothers during breast feeding is still a matter of debate, and they seem only to be of value if the infant already suffers from obvious allergic symptoms [13]. Hypo-allergic formulae have an inhibitory effect upon the development of cow's milk allergy [7,37]. Moreover, late introduction (>age of 6 months) of solid foods seem to be advisable in atopic infants [10,20].…”

Section: Prevention Of Atopymentioning

confidence: 99%

Early events in atopy

Bever

2002

Eur J Pediatr

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Section: Prevention Of Atopymentioning

confidence: 99%

Early events in atopy

Bever

2002

Eur J Pediatr

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“…In the studies conducted to date, there are major differences in feeding formulations such that the preventive effect of HF in high-risk infants is still inconclusive [12,14]. Further studies are necessary to assess relevant outcomes of feeding HF compared to regular cow’s milk infant formula (CM).…”

Section: Introductionmentioning

confidence: 99%

Partial Protein-Hydrolyzed Infant Formula Decreased Food Sensitization but Not Allergic Diseases in a Prospective Birth Cohort Study

Kuo¹,

Liu²,

et al. 2010

Int Arch Allergy Immunol

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Background: Exposure to cow’s milk protein in early infancy could lead to increased rates of allergic diseases later in life. We investigated whether feeding a protein-hydrolyzed formula (HF) in the first 6 months of life decreased allergic diseases up to 36 months later. Methods: Newborns who had at least 1 first-degree family member with a history of atopy and could not breast-feed were enrolled. They were fed with HF or cow’s milk infant formula (CM) for at least 6 months via an open-label protocol and were monitored prospectively at 6, 18 and 36 months of age to assess allergy sensitization and allergic diseases. Results: A total of 1,002 infants were enrolled and 679 infants were consistently fed the same formula for the first 6 months of life (345 HF and 334 CM). The percentage of food sensitization (especially to milk protein) was significantly lower in the HF group than in the CM group at 36 months (12.7 vs. 23.4%, p = 0.048). There was no significant difference in the prevalence of aeroallergen sensitization between the groups. Occurrence of allergic diseases during the first 3 years of life was significantly correlated with aeroallergen sensitization, but not to food allergen sensitization, parental atopy or feeding types. Conclusions: Infants fed with HF during the first 6 months of life had a significantly lower percentage of sensitization to milk protein allergens, but not allergic diseases during the first 3 years of life. Avoidance of cow’s milk protein alone in infancy is not enough to decrease rates of allergic diseases.

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“…In only one single trial, an extensive hydrolysate was compared to a partial hydrolysate, whereas an extensive hydrolysate was compared to an ultra®ltrated formula in another trial [4]. So, the authors came to the logical conclusion that much more well-designed studies are needed before conclusions can be drawn and recommendations proposed [4]. In the meantime, the results of an interesting trial comparing a partial hydrolysate to two extensive hydrolysates have been published [2].…”

mentioning

confidence: 94%

“…In fact, this means that there are only two hydrolysates (Nutramigen and NestleÂ -HA) that have been clinically tested in more than one published prospective cohort study in infants at risk for atopy. In only one single trial, an extensive hydrolysate was compared to a partial hydrolysate, whereas an extensive hydrolysate was compared to an ultra®ltrated formula in another trial [4]. So, the authors came to the logical conclusion that much more well-designed studies are needed before conclusions can be drawn and recommendations proposed [4].…”

mentioning

confidence: 96%