Prospective Clinical Trial Evaluating the Efficacy of Photodynamic Therapy for Symptomatic Circumscribed Choroidal Hemangioma

Boixadera, Anna; Arumí, José García; Martínez-Castillo, Vicente; Encinas, José Luis; Elizalde, Javier; Blanco-Mateos, Gonzalo; Caminal, Josep M.; Capeáns, C.; Armadá, Félix; Navea, Amparo; Olea, J.L.

doi:10.1016/j.ophtha.2008.08.029

Cited by 102 publications

(71 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En los últimos años se ha descrito la TFD como una alternativa exitosa para tratar a estos pacientes [1][2][3][4] . La terapia actúa de forma selectiva sobre el endotelio vascular, respeta el resto de estructuras y su yatrogenia es menor que la de otros tratamientos 2 .…”

Section: Discussionunclassified

Tratamiento mediante terapia fotodinámica del hemangioma coroideo circunscrito

Andonegui

Arcelus

Jiménez-Lasanta

2010

Archivos de la Sociedad Española de Oftalmología

View full text Add to dashboard Cite

Casos clínicos: Se presentan las características clínicas de tres pacientes con hemangioma coroideo circunscrito y exudación subfoveal, detectada mediante tomografía óptica de coherencia, tratados con éxito mediante terapia fotodinámica.Discusión: La terapia fotodinámica es actualmente la alternativa terapéutica más efectiva para tratar los hemangiomas coroideos circunscritos asociados a exudación subfoveal. Respecto a la utilización de este tratamiento quedan por definir algunas cuestiones como son si se debe buscar o no la desaparición total de la masa tumoral, los parámetros de láser más adecuados en estos casos o la forma de aplicación de los impactos. Treatment with photodynamic therapy of circumscribed choroidal hemangioma Keywords:Circumscribed choroidal haemangioma Photodynamic therapy Subfoveal exudation A B S T R A C TCase reports: The clinical characteristics of three patients with circumscribed choroidal haemangioma and subfoveal exudation detected by optical coherence tomography are described in this paper. The three patients were successfully treated with photodynamic therapy.Discussion: Photodynamic therapy is the most adequate therapeutic option for circumscribed choroidal hemangioma associated with subfoveal exudation. Some questions such as whether attempts should be made to obtain a complete tumour regression, laser settings or the way the spots must be applied remain unresolved.

show abstract

Section: Discussionunclassified

Tratamiento mediante terapia fotodinámica del hemangioma coroideo circunscrito

Andonegui

Arcelus

Jiménez-Lasanta

2010

Archivos de la Sociedad Española de Oftalmología

View full text Add to dashboard Cite

show abstract

“…Multiple case series have been reported demonstrating that vPDT therapy achieves high rates of tumour control with minimal complications. [33][34][35][36][37][38] Choroidal haemangiomas can be effectively treated using the standard vPDT protocol-verteporfin dosage 6 mg/m 2 BSA and vPDT laser fluence 50 J/cm 2 (600 mW/cm 2 for 83 s). 36,37 Alternative vPDT protocols have been reported, generally involving a higher vPDT laser fluence of 100 J/cm 2 (600 mW/cm 2 for 166 s).…”

Section: Vpdt Treatment Protocolsmentioning

confidence: 99%

“…[33][34][35][36][37][38] Choroidal haemangiomas can be effectively treated using the standard vPDT protocol-verteporfin dosage 6 mg/m 2 BSA and vPDT laser fluence 50 J/cm 2 (600 mW/cm 2 for 83 s). 36,37 Alternative vPDT protocols have been reported, generally involving a higher vPDT laser fluence of 100 J/cm 2 (600 mW/cm 2 for 166 s). [33][34][35]38 The maximum laser spot size generated by most vPDT laser systems is around 7000 μm.…”

Section: Vpdt Treatment Protocolsmentioning

confidence: 99%

Photodynamic therapy: current role in the treatment of chorioretinal conditions

Newman

2016

Eye

View full text Add to dashboard Cite

Verteporfin photodynamic therapy (vPDT) is a selective vaso-occlusive treatment that targets choroidal vascular abnormalities. It was initially developed to treat neovascular age-related macular degeneration using the 'standard' vPDT protocol (verteporfin 6 mg/ m 2 , vPDT laser fluence 50 J/cm 2 ). vPDT therapy has subsequently evolved as an important treatment modality for a range of other chorioretinal conditions including choroidal haemangioma, central serous chorioretinopathy, polypoidal choroidal vasculopathy, and peripapillary choroidal neovascularisation. Various 'safety-enhanced' vPDT protocols have been devised to optimise treatment outcomes, typically using reduced dose verteporfin (verteporfin 3 mg/m 2 ) or reduced fluence vPDT (vPDT laser fluence 25 J/cm 2 ). This paper reviews the current role of vPDT therapy in the treatment of chorioretinal conditions.

show abstract

“…PDT is now the preferred treatment in most centres. [44][45][46][47] This yields excellent anatomical and functional results with minimal risk of complications ( Figure 9). The exact treatment parameters of PDT are still debated but several authors have recommended bolus injections of Verteporfin, increased application time of laser energy, and overlapping treatment spots.…”

Section: Eyementioning

confidence: 99%

“…48,49 Recent studies suggest that satisfactory results can be achieved using the same treatment settings as for exudative agerelated macular degeneration ( Figure 9). 44,48 If PDT is not available or is unsuccessful, or if the disease is too advanced, then alternative treatments include transpupillary thermotherapy, external beam, or proton beam radiotherapy. 37,[50][51][52][53][54][55][56] Follow-up examinations should include ultrasound measurement of tumour dimensions and OCT examinations of macular oedema, as appropriate.…”

Section: Eyementioning

confidence: 99%

Congenital vascular malformations of the retina and choroid

Heimann

Damato

2009

Eye

View full text Add to dashboard Cite

Purpose To review recent advances in the diagnosis and treatment of congenital vascular malformations of the retina and choroid. Methods Review of the current literature on retinal haemangioblastoma, racemose haemangiomatosis, retinal cavernous haemangioblastoma, circumscribed choroidal haemangioma, and diffuse choroidal haemangioma. Conclusion The management of patients with congenital vascular lesions of the retina and choroid is advancing rapidly through recent developments in genetic testing, ocular imaging, and treatment. Most are associated with systemic disease, which may be lifethreatening. New therapeutic methods such as Verteporfin photodynamic therapy and antiangiogenic therapy have significantly improved the treatment of retinal and choroidal angiomas and vascular malformations. Ophthalmologists have a major role in detecting and diagnosing these tumours and in providing long-term care in collaboration with a specialist in the field.

show abstract

Prospective Clinical Trial Evaluating the Efficacy of Photodynamic Therapy for Symptomatic Circumscribed Choroidal Hemangioma

Cited by 102 publications

References 26 publications

Tratamiento mediante terapia fotodinámica del hemangioma coroideo circunscrito

Tratamiento mediante terapia fotodinámica del hemangioma coroideo circunscrito

Photodynamic therapy: current role in the treatment of chorioretinal conditions

Congenital vascular malformations of the retina and choroid

Contact Info

Product

Resources

About