Prospective case-control study of encephalopathy in children with dengue hemorrhagic fever.

Cam, Bach Van; Fonsmark, Lise; Hue, Nguyen Bach; Phuong, Nguyen Thị; Poulsen, Anja; Heegaard, Erik D.

doi:10.4269/ajtmh.2001.65.848

Cited by 218 publications

(199 citation statements)

References 14 publications

Supporting

Mentioning

171

Contrasting

Unclassified

Order By: Relevance

“…A partir de 1997, alguns estudos deram subsídios para tais hipóteses. A detecção da presença de anticorpos da classe IgM no LCR sugeriu que a infecção viral poderia ocorrer pela hemorragia ou pelas t rocas entre os vasos sanguíneos e as células nerv o s a s , o que possibilitaria a passagem de anticorpos do s o ro para o LCR 8 , podendo ser mediada por citocinas 9 . Embora o isolamento viral em LCR seja raramente referido na literatura, aventou-se a possibilidade da passagem viral pela barreira hematoencefálica durante a fase virêmica 8,9 .…”

unclassified

“…A detecção da presença de anticorpos da classe IgM no LCR sugeriu que a infecção viral poderia ocorrer pela hemorragia ou pelas t rocas entre os vasos sanguíneos e as células nerv o s a s , o que possibilitaria a passagem de anticorpos do s o ro para o LCR 8 , podendo ser mediada por citocinas 9 . Embora o isolamento viral em LCR seja raramente referido na literatura, aventou-se a possibilidade da passagem viral pela barreira hematoencefálica durante a fase virêmica 8,9 . Por meio de cultura de tecidos, utilizando células de neuroblastoma de ratos e de humanos, num modelo experimental, i d e ntificou-se, por imunofluorescência, a presença de antígenos virais no citoplasma e ao redor do núcleo, comprovando a existência de receptores virais do dengue envolvidos nos mecanismos de infecção do SNC 10 .…”

unclassified

“…Por meio de análise imuno-histoquímica de material de necrópsia foram demonstrados antíge-nos virais em células fagocitárias de fígado, pulmão e baço de cinco casos fatais por dengue, associados à encefalopatia, assim como em veias de pequeno e médio calibres do espaço de Vi rchow -Robin, infiltrando substância branca e cinzenta, e próximas a neurônios com morfologia anorm a l 1 1 . Como os v í ru s do dengue se re p roduzem em macrófagos, é plausível admitir a infiltração dessas células infectadas no SNC nos casos de encefalite por dengue 9 . Além dos exames de investigação clínica, que incluem hemograma, contagem de plaquetas, pro v a do laço e dosagens bioquímicas (uréia, cre a t i n i n a , transferases e bilirrubina total e frações), o diagnóstico laboratorial de dengue requer determ i n a ç ã o dos títulos de anticorpos contra antígenos DEN1, DEN2, DEN3 e DEN4, por inibição de hemaglutinação (HI) e titulação de IgM, por enzima-imunoensaio (EIA) com antígeno tetravalente de dengue.…”

unclassified

See 2 more Smart Citations

Manifestações neurológicas de dengue: estudo de 41 casos

Ferreira

Cavalcanti²,

Coelho³

et al. 2005

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Dengue é a infecção arboviral humana mais f reqüente, com 50 milhões de casos por ano e 2,5 a 3 bilhões de pessoas em risco de contaminação, segundo estimativa da OMS 1 . A infecção se apre s e n t a classicamente como febre do dengue (DC), uma doença autolimitada, mas severa, semelhante à influenza, ou como febre hemorrágica do dengue ou dengue hemorrágico (FHD). No sudeste da Ásia, é doença predominantemente pediátrica e caracterizada pelo aumento da permeabilidade vascular, perda de plasma, manifestações hemorrágicas e t ro m b o c i t o p e n i a 2 . A sintomatologia do dengue depende da forma clínica, podendo variar de cefaléia a ampla gama de manifestações neuro l ó g i c a s . No dengue clássico, o quadro febril, agudo, com d uração de dois a sete dias, habitualmente associa-se a dois ou mais sinais ou sintomas, dentre: cefaléia grave, dor re t rorbital, mialgia grave, artralgia, r a s h característico, manifestações hemorrágicas e leucopenia. A mialgia do dengue deve-se à presença de infiltrado mononuclear perivascular leve a moderado e acúmulo de lipídeos, acarretando o sin-

show abstract

unclassified

See 1 more Smart Citation

Manifestações neurológicas de dengue: estudo de 41 casos

Ferreira

Cavalcanti²,

Coelho³

et al. 2005

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…2 Another study in Viet Nam found that 0.5% of children admitted for dengue hemorrhagic fever (DHF), which is a subset of severe dengue, had serologically confirmed DENV infection with encephalopathy, although rates of dengue-associated neurologic diseases as high as 21% have been reported. 3,4 The most efficient vector for DENV is Aedes aegypti, which is present in limited areas of the southern United States, but its current geographic distribution is not well-documented. 5 Ae.…”

mentioning

confidence: 99%

Surveillance for Dengue and Dengue-Associated Neurologic Syndromes in the United States

Waterman

Margolis

Sejvar

2015

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Autochthonous dengue virus transmission has occurred in the continental United States with increased frequency during the last decade; the principal vector, Aedes aegypti, has expanded its geographic distribution in the southern United States. Dengue, a potentially fatal arboviral disease, is underreported, and US clinicians encountering patients with acute febrile illness consistent with dengue are likely to not be fully familiar with dengue diagnosis and management. Recently, investigators suggested that an outbreak of dengue likely occurred in Houston during 2003 based on retrospective laboratory testing of hospitalized cases with encephalitis and aseptic meningitis. Although certain aspects of the Houston testing results and argument for local transmission are doubtful, the report highlights the importance of prospective surveillance for dengue in Aedes-infested areas of the United States, the need for clinical training on dengue and its severe manifestations, and the need for laboratory testing in domestic patients presenting with febrile neurologic illness in these regions to include dengue.Dengue is an arboviral disease of major public health significance caused by four serologically related flaviviruses, dengue viruses (DENVs 1-4), with an expanding worldwide distribution.1 Although many DENV infections are asymptomatic, classic clinical dengue manifests as an acute febrile illness, with symptoms that include headache, retro-orbital pain, myalgia, arthralgia, and rash. Clinical dengue is usually a self-limited illness of about 1 week's duration, but severe illness can occur in both healthy persons and those with other underlying diseases. A relatively small percentage (approximately 10%) of persons with clinical dengue progresses to severe disease because of plasma leakage, which can lead to decompensated shock and death if not carefully managed with appropriate fluid therapy. Most patients requiring hospitalization for dengue have severe disease or complications related to underlying comorbid disease. DENVs seem to be less neurotropic than other flaviviruses, such as West Nile virus, St. Louis encephalitis virus, and Japanese encephalitis virus. DENV-associated neurologic disease, including neuroinvasive disease, has been rarely documented by isolation of virus and detection of DENV-specific immunoglobulin M (IgM) antibody in cerebrospinal fluid (CSF) or brain tissue. In Viet Nam, about 1% of patient hospitalizations with suspected dengue had encephalitis or aseptic meningitis syndromes. 2Another study in Viet Nam found that 0.5% of children admitted for dengue hemorrhagic fever (DHF), which is a subset of severe dengue, had serologically confirmed DENV infection with encephalopathy, although rates of dengue-associated neurologic diseases as high as 21% have been reported. 3,4The most efficient vector for DENV is Aedes aegypti, which is present in limited areas of the southern United States, but its current geographic distribution is not well-documented. Ae. albopictus is a less efficient tran...

show abstract

“…15,19 Both WNV and DENV can cause neuroinvasive disease. 17,18,[20][21][22][23][24] Some researchers have hypothesized that dengue endemicity might eventually produce sufficient cross-protective immunity to modulate WNV disease, resulting in a less severe clinical syndrome and making WNV difficult to detect in dengue-endemic countries. 19,25 These factors may explain why few cases of human WNV disease have been detected in Latin America and the Caribbean.…”

Section: Discussionmentioning

confidence: 99%

Enhanced West Nile Virus Surveillance in a Dengue-Endemic Area—Puerto Rico, 2007

Torres-Aponte

Luce²,

Hunsperger³

et al. 2013

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. In June of 2007, West Nile virus (WNV) was detected in sentinel chickens and blood donors in Puerto Rico, where dengue virus (DENV) is hyperendemic. Enhanced human surveillance for acute febrile illness (AFI) began in eastern Puerto Rico on July 1, 2007. Healthcare providers submitted specimens from AFI cases for WNV and DENV virology and serology testing. Over 6 months, 385 specimens were received from 282 cases; 115 (41%) specimens were DENV laboratorypositive, 86 (31%) specimens were laboratory-indeterminate, and 32 (11%) specimens were laboratory-negative for WNV and DENV. One WNV infection was detected by anti-WNV immunoglobulin M (IgM) antibody and confirmed by a plaque reduction neutralization test. DENV and WNV infections could not be differentiated in 27 cases (10%). During a period of active WNV transmission, enhanced human surveillance identified one case of symptomatic WNV infection. Improved diagnostic methods are needed to allow differentiation of WNV and DENV in dengue-endemic regions.

show abstract

Prospective case-control study of encephalopathy in children with dengue hemorrhagic fever.

Cited by 218 publications

References 14 publications

Manifestações neurológicas de dengue: estudo de 41 casos

Manifestações neurológicas de dengue: estudo de 41 casos

Surveillance for Dengue and Dengue-Associated Neurologic Syndromes in the United States

Enhanced West Nile Virus Surveillance in a Dengue-Endemic Area—Puerto Rico, 2007

Contact Info

Product

Resources

About