Prospective association of sex steroid concentrations with periodontal progression and incident tooth loss

Abstract

No consistent associations of sexual steroids with periodontal progression or tooth loss were found. Further cohort studies are necessary to evaluate possible associations between endocrinological parameters, like supra- or subphysiologic testosterone concentrations, and periodontal progression or tooth loss.

“Low Testosterone Levels in Body Fluids Are Associated With Chronic Periodontitis”

“…In the second step, 15 more articles were excluded because they did not answer the focus question, were experimental studies, reviews, or studies conducted in children (younger than 12 years old) and/or women (see the appendix). A total of eight studies (Daltaban et al, 2006; Kuraner et al, 1991; Orwoll et al, 2009; Samietz et al, 2016; Singh et al, 2011; Steffens, Wang, et al, 2015; Vittek et al, 1979; Vittek et al, 1984) were included in the present systematic review and processed for data extraction (Figure 1).…”

“…Item 1 = study issue is clearly focused; Item 2 = cohort is recruited in an acceptable way; Item 3 = exposure is accurately measured; Item 4 = outcome is accurately measured; Item 5 = confounding factors are addressed; Item 6 = follow-up is long and complete; Item 7 = results are clear; Item 8 = results are precise; Item 9 = results are credible; Item 10 = results can be applied to the local population; Item 11 = results fit with available evidence; Item 12 = there are important clinical implications. 1991Positive b (saliva) Negative Orwoll et al (2009) NA Negative Samietz et al (2016) NA Negative Singh et al 2011NA Positive a Steffens, Wang, et al (2015) NA Positive a Vittek et al (1979) Positive b (gingiva) Negative Vittek et al (1984) Negative (saliva) NA et al, 2011; Steffens, Wang, et al, 2015;Vittek et al, 1979;Vittek et al, 1984). To the best of our knowledge from indexed literature, this is the first study systematically reviewing the effect of testosterone levels in men's periodontal status.…”

“…A limited number of studies have suggested a relationship between common oral diseases such as CP and male reproductive health conditions, including erectile dysfunction, low testosterone levels, and male infertility (Daltaban et al, 2006;Kellesarian, Yunker, et al, 2016;Kuraner et al, 1991;Orwoll et al, 2009;Samietz et al, Note. Item 1 = study issue is clearly focused; Item 2 = cohort is recruited in an acceptable way; Item 3 = exposure is accurately measured; Item 4 = outcome is accurately measured; Item 5 = confounding factors are addressed; Item 6 = follow-up is long and complete; Item 7 = results are clear; Item 8 = results are precise; Item 9 = results are credible; Item 10 = results can be applied to the local population; Item 11 = results fit with available evidence; Item 12 = there are important clinical implications.…”

“…Serum Testosterone Levels. Four studies (Kuraner et al, 1991;Orwoll et al, 2009;Samietz et al, 2016;Vittek et al, 1979) reported a negative association between serum testosterone levels and periodontal inflammatory parameters. Orwoll et al (2009) reported no significant difference in periodontal parameters (CAL, PD, and BOP), CP progression (odds ratio [OR] = 0.97, 95% confidence interval [CI: 0.83, 1.14]), tooth loss (OR = 1.01, 95% CI [0.87, 1.18]), and total testosterone levels in a cohort of 1,210 men followed for 3 years.…”

“…Chronic periodontitis (CP) is an inflammatory condition of the tooth supporting structures (cementum, gingiva, periodontal ligament, and alveolar bone) that if left untreated progresses to bone destruction and tooth loss (Ram, Parthiban, Sudhakar, Mithradas, & Prabhakar, 2015). The relationship between female sex hormones (estrogens) and periodontal disease in women during puberty, pregnancy, and menopause, or taking oral contraceptives has been widely reported (Jafri, Bhardwaj, Sawai, & Sultan, 2015; Shapiro & Freeman, 2014); however, only a limited number of studies (Daltaban, Saygun, & Bolu, 2006; Kuraner et al, 1991; Orwoll et al, 2009; Samietz et al, 2016; Singh, Makker, Tripathi, Singh, & Gupta, 2011; Steffens, Wang, et al, 2015; Vittek, Kirsch, Rappaport, Bergman, & Southren, 1984; Vittek, Rappaport, Gordon, Munnangi, & Southren, 1979) have investigated the association between testosterone levels in men and CP. ElAttar, Lin, and Tira (1982) reported testosterone inhibitory properties in vitro in the cyclooxygenase pathway of arachidonic acid metabolism in gingiva.…”