Prospective Association of Serum and Dietary Magnesium with Colorectal Cancer Incidence

Polter, Elizabeth J.; Onyeaghala, Guillaume C.; Lutsey, Pamela L.; Folsom, Aaron R.; Joshu, Corinne E.; Platz, Elizabeth A.; Prizment, Anna E.

doi:10.1158/1055-9965.epi-18-1300

Cited by 16 publications

(15 citation statements)

References 51 publications

(49 reference statements)

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“…Second, plasma magnesium concentrations were only assessed at baseline; not only more frequent measurements would have been more informative but would have allowed verifying other potential confounders. Third, although previous studies suggested that the association between magnesium and risk of cancer varied between different cancer types, including colorectal [18], prostate [19, 24], and lung [25] cancers, there was no significant heterogeneity observed across different cancer subtypes in the current study. However, our current study was underpowered to investigate individual cancers.…”

Section: Discussioncontrasting

confidence: 68%

“…Research ﬁndings to date on the association between magnesium status and incident risk of cancer remain inconsistent. Polter et al [18] found a higher risk of colorectal cancer with lower serum magnesium among females but not males. Dai et al [24] suggested low serum magnesium levels was significantly associated with high-grade prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The association between dietary intake and plasma magnesium remain unclear. A meta-analysis of 48 small clinical trials (total n = 2,131) reported that blood magnesium was responsive to dietary supplementation [36], while some studies suggested these 2 markers may not necessarily be interchangeable [18]. Given that the metabolism of magnesium has not been completely elucidated [11], and there is no consensus on identified sensitive biomarkers for determining optimal magnesium status [10, 37], individual magnesium status may be more appropriately be assessed by multiple biomarkers (such as serum/plasma magnesium concentration, RBC concentration and urinary magnesium, dietary magnesium intake, and magnesium loading test) in future studies [37].…”

Section: Discussionmentioning

confidence: 99%

“…Some prospective studies suggested an inverse association between magnesium intake and risk of cancer [12-15], while others found no significant associations [16, 17]. Moreover, data concerning the prospective association between blood magnesium and incident risk of cancers are limited [18-20] and the results are still inconclusive. More importantly, most prior prospective epidemiologic and interventional studies mentioned above have been conducted mainly in North American and European countries rather than in Asian and developing countries [12-20].…”

Section: Introductionmentioning

confidence: 99%

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Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Lin

Song

et al. 2020

Ann Nutr Metab

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Objective: The association between plasma magnesium and risk of incident cancer remains inconclusive in previous studies. We aimed to investigate the prospective relationship of baseline plasma magnesium concentrations with the risk of incident cancer and to examine possible effect modifiers. Methods: A nested case-control study with 228 incident cancer cases and 228 matched controls was conducted using data from the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, controlled trial, conducted from May 2008 to August 2013. Study outcomes included incident cancer and its subtypes. Results: When plasma magnesium concentrations were assessed as quartiles, a significantly higher incident risk of total cancer was found in participants in quartile 1 (<0.76 mmol/L; odds ratio [OR] = 2.70; 95% CI: 1.33–5.49) and quartile 4 (≥0.89 mmol/L; OR = 2.05; 95% CI: 1.12–3.76), compared with those in quartile 3 (0.83 to <0.89 mmol/L). In cancer site-specific analyses, similar trends were found for gastrointestinal cancer, esophageal cancer, gastric cancer, breast cancer, lung cancer, and other cancers. Furthermore, none of the variables, including age, sex, current smoking status, current alcohol intake, BMI, systolic blood pressure, and total cholesterol levels at baseline significantly modified the association between plasma magnesium and cancer risk. Conclusions: Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to <0.89 mmol/L among hypertensive adults.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Lin

Song

et al. 2020

Ann Nutr Metab

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“…Mg deficiency, due to either low Mg intake or excessive Mg waste, can be responsible of defects in DNA repairing mechanisms leading to genomic instability [ 11 ]. Hypomagnesaemia is frequent in patients with CRC [ 12 , 13 ] and serum Mg level detection was proposed as a biomarker of efficacy and outcome in patients with advanced CRC treated with cetuximab [ 14 , 15 ] and bevacizumab [ 16 ]. Hypomagnesaemia in cancer patients might be due to iatrogenic causes [ 17 ] or to the tumour itself, which may act as a Mg trap [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Imbalance of Mg Homeostasis as a Potential Biomarker in Colon Cancer

et al. 2021

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Background: Increasing evidences support a correlation between magnesium (Mg) homeostasis and colorectal cancer (CRC). Nevertheless, the role of Mg and its transporters as diagnostic markers in CRC is still a matter of debate. In this study we combined X-ray Fluorescence Microscopy and databases information to investigate the possible correlation between Mg imbalance and CRC. Methods: CRC tissue samples and their non-tumoural counterpart from four patients were collected and analysed for total Mg level and distribution by X-Ray Fluorescence Microscopy. We also reviewed the scientific literature and the main tissue expression databases to collect data on Mg transporters expression in CRC. Results: We found a significantly higher content of total Mg in CRC samples when compared to non-tumoural tissues. Mg distribution was also impaired in CRC. Conversely, we evidenced an uncertain correlation between Mg transporters expression and colon malignancies. Discussion: Although further studies are necessary to determine the correlation between different cancer types and stages, this is the first report proposing the measurement of Mg tissue localisation as a marker in CRC. This study represents thus a proof-of-concept that paves the way for the design of a larger prospective investigation of Mg in CRC.

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The association among calorie, macronutrient, and micronutrient intake with colorectal cancer: A case–control study

Nasab

Ahmadzadeh

Doaei

et al. 2022

Food Science & Nutrition

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The risk of colorectal cancer (CRC) can be influenced by dietary components. This study aims to investigate the association between dietary intake and CRC in Iranian adults. This hospital‐based case–control study was performed on 160 patients with CRC and 320 healthy people. General and pathological data were collected through face‐to‐face interviews. A validated food frequency questionnaire (FFQ) was used to assess the intake of calories, macronutrients, and micronutrients. The case group had a significantly higher intake of calories, carbohydrates, vitamin A, vitamin K, fluoride, and molybdenum and a lower intake of vitamin E, vitamin B1, beta carotene, biotin, folate, magnesium, selenium, manganese, and fiber (all p < .001). CRC was positively associated with the intake of carbohydrate (OR: 1.01, CI% 1.03–1.01, p = .001), and vitamin A (OR: 1.009, CI 95% 1.006–1.01, p = .001) and negatively associated with intake of fiber (OR: 0.67, CI 95% 0.59–0.76, p = .001), beta carotene (OR: 0.99, CI 95% 0.99–0.99, p = .001), vitamin E (OR: 0.27, CI 95% 0.15–0.47, p = .001), folate (OR: 0.98 CI 95% 0.97–0.98, p = .001), and biotin (OR: 0.83, CI 95% 0.77–0.90, p = .001). The associations remained significant after adjusting for age and sex. Further adjustments for physical activity, alcohol consumption, and smoking did not change the results. The results identified that the risk of colorectal cancer can be influenced by dietary intake. Further longitudinal studies are needed to confirm these findings and to identify the underlying mechanisms of the effects of dietary components on the risk of colorectal cancer.

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Prospective Association of Serum and Dietary Magnesium with Colorectal Cancer Incidence

Abstract: Background: Laboratory and epidemiologic research suggests a protective role of magnesium in colorectal cancer development. We estimated the associations of serum and dietary magnesium with colorectal cancer incidence in the Atherosclerosis Risk in Communities (ARIC) study.

Cited by 16 publications

References 51 publications

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study

Imbalance of Mg Homeostasis as a Potential Biomarker in Colon Cancer

The association among calorie, macronutrient, and micronutrient intake with colorectal cancer: A case–control study

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