Prospective assessment of pre-existing and de novo anti-HLA IgE in kidney, liver, lung and heart transplantation
Jasmin Mucha,
Ara Cho,
Anna Marianne Weijler
et al.
Abstract:IntroductionAntibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation. Anti-HLA donor-specific antibodies (DSA) of the IgG isotype are mainly responsible for ABMR. Recently DSA of the IgE isotype were demonstrated in murine models as well as in a small cohort of sensitized transplant recipients. In the present study, we aimed to determine the frequency of pre-existing and de novo anti-HLA IgE antibodies in a cohort of 105 solid organ transplant recipients.MethodsWe prosp… Show more
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