Prospective assessment of clinical symptoms associated with enterovirus and parechovirus genotypes in a multicenter study in Dutch children

Crom, Stephanie C. M. de; Rossen, John W. A.; Moor, Ronald A. de; Veldkamp, E J M; Furth, A. Marceline van; Obihara, Charlie C.

doi:10.1016/j.jcv.2016.01.014

Cited by 28 publications

(14 citation statements)

References 24 publications

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“…Like enteroviruses, the epidemiology and clinical syndromes associated with HPeV vary by genotype 5 . HPeV1 and HPeV6 are primarily associated with milder gastrointestinal symptoms and presentation in children aged > 6 months 18 , 19 . HPeV may be isolated from respiratory specimens in children presenting with influenza‐like illness 20 and in faecal specimens from children presenting with viral diarrhoea 21 …”

Section: Clinical Presentation and Complicationsmentioning

confidence: 99%

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Parechovirus: an important emerging infection in young infants

Britton

Jones

Macartney

et al. 2018

Medical Journal of Australia

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Epidemics of human parechovirus (HPeV) causing disease in young children have occurred every 2 years in Australia since 2013. HPeV genotype 3 caused the epidemic from late 2017 to early 2018. Most HPeV infections cause no or mild symptoms including gastroenteritis or influenza-like illness. Characteristically, young infants present with fever, irritability and on occasions a diffuse rash ("red, hot and angry" babies). Severe disease can manifest as meningoencephalitis, seizures or sepsis-like presentations (including septic shock), or less common presentations including signs of surgical abdomen. Testing for HPeV by specific molecular tests is indicated in children younger than 6 months of age with characteristic presentations without another confirmed diagnosis including febrile illnesses with other suggestive features (eg, rash, seizures), sepsis syndromes (including shock), and suspected meningoencephalitis (which may be detected by magnetic resonance imaging only). There are no effective antiviral therapies. Treatment is primarily supportive, including management of complications. Some infants with severe HPeV infection may have adverse neurodevelopment. Follow-up by a paediatrician is recommended.

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Section: Clinical Presentation and Complicationsmentioning

confidence: 99%

“…Stool testing appears to be most sensitive (95–98%), followed by CSF testing (84–95%) 12 , 36 . Characteristically, CSF pleocytosis is mild or absent in HPeV3 central nervous system infection, in contrast to other causes of encephalitis 8 , 12 , 14 , 18 , 19 , 23 …”

Section: Diagnosis Of Parechovirusmentioning

confidence: 99%

Parechovirus: an important emerging infection in young infants

Britton

Jones

Macartney

et al. 2018

Medical Journal of Australia

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“…Parechovirus and EV CNS infections are clinically indistinguishable and have similar associated acute complications, for example, neonatal severe sepsis-like syndrome, myocarditis and hepatitis 45. EV RT-PCR will not detect parechoviruses for which specific RT-PCR testing is required.…”

Section: Should Infants and Children With Parechovirus Csf Infectionsmentioning

confidence: 99%

Fifteen-minute consultation: enterovirus meningitis and encephalitis—when can we stop the antibiotics?

Drysdale

Kelly

2016

Arch Dis Child Educ Pract Ed

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Enterovirus (EV) is the most common cause of aseptic meningitis and has a benign course, unlike EV encephalitis, which can result in long-term neurological sequelae. There are no active treatments or prophylactic agents, and management is purely supportive. Obtaining an EV-positive cerebrospinal fluid result usually allows antimicrobial treatment to be stopped. This review will answer some of the common questions surrounding EV meningitis/encephalitis.

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“…The genome of HPeV is about 7,300 nucleotides (nt) in length encoding a single large open reading frame (ORF), which comprised three regions P1, P2, and P3 and encodes a polyprotein posttranslationally cleaved into three structural proteins and seven nonstructural proteins. HPeVs were shown to be highly diverse, with up to 16 provisionally assigned types (4, 5), where HPeV1 and HPeV2 were originally known as echoviruses 22 and 23 (6). Most of the HPeV infections are mild, including diarrhea and respiratory tract infection (7, 8).…”

Section: Genome Announcementmentioning

confidence: 99%