Prospective assessment of 18F-FDG PET/CT in detection of recurrent ovarian cancer

Gouhar, Ghada K.; Siam, Soha; Sadek, Somayya M.; Ahmed, Reda A.

doi:10.1016/j.ejrnm.2013.08.005

Cited by 11 publications

(19 citation statements)

References 29 publications

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“…Our results are generally in matching with earlier studies [7,[26][27][28][29][30][31][32] which had patient-based specificity, sensitivity, and accuracy of 85-100%, 86-100%, and 85-100%, respectively, while at the region level, the sensitivity and specificity ranged from 41-78% and 75-99% and accuracy 72-96%.…”

Section: Discussionsupporting

confidence: 91%

“…Ovarian cancer is the second most frequent gynecologic malignancy (preceded by cervix carcinoma) with up to 25 and 75 % chance of 2 years' recurrence of early and advance stages respectively. Thus, the early recurrence detection is crucial for planning of the treatment roadmap aiming to have a better life quality with longer period of disease-free condition [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…The serial assessment of CA-125 (serum tumor marker) level is broadly used for the monitoring of the tumor recurrence; however, lack of the site and size information and non-specificity for ovarian cancer (OC) (around 20% of OC is CA-125 negative) are all considered as limitation and disadvantages [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…OC recurrence imaging approaches include CT and MRI modalities; however, the main OC metastases are to the peritoneal rather than the parenchymal way which makes the detection of small implanted tumor on the visceral surface challenging [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of PET–CT in the evaluation of suspected recurrent ovarian carcinoma

El-Hariri

Harira

Riad

2019

Egypt J Radiol Nucl Med

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Background:The purpose of the current study is to assess the PET/CT potential value in the diagnosis of ovarian cancer recurrence.Results: PET/CT scan described suspicion of ovarian cancer (OC) recurrence in 20 local pelvic lesions with 100% sensitivity, accuracy, and specificity and in 18 peritoneal lesions with sensitivity and specificity of 76.19 and 95.65 and accuracy of 89.55%. While PET/CT suspected OC recurrence in 5 pelvic, 9 para-aortic, and 10 distant lymph nodes, the sensitivity, specificity, and accuracy were (80, 98.38, and 97 %), (66.67, 94.82, and 91.04%), and (90, 98.24, and 97.01), respectively. PET/CT scan described suspicion of OC recurrence in 5 distant organ metastases; the accuracy, sensitivity, and specificity were 100%. The lesion-based accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT scan were 95.77, 85.7, 97.89, 90.5 and 97% while the corresponding patient-based values were 94.44, 96.87, 75, and 94.44% and 96.87 and 75%. Conclusion: PET-CT is a helpful modality in the assessment of OC recurrence; it can detect and localize the recurrence with high accuracy, thus can influence and modify the treatment plan, and reduces the need for 2nd look surgery.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Usefulness of PET–CT in the evaluation of suspected recurrent ovarian carcinoma

El-Hariri

Harira

Riad

2019

Egypt J Radiol Nucl Med

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“…[34] Negative PET/CT scan findings also have negative predictive value of 90% for detection of recurrence; patients with negative scans were associated with progression-free survival in approximately 2-year follow-up. [39]…”

Section: Evidence Synthesismentioning

confidence: 99%

Systematic review on the accuracy of positron emission tomography/computed tomography and positron emission tomography/magnetic resonance imaging in the management of ovarian cancer: Is functional information really needed?

et al. 2017

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Ovarian cancer (OC) often presents at an advanced stage with frequent relapses despite optimal treatment; thus, accurate staging and restaging are required for improving treatment outcomes and prognostication. Conventionally, staging of OC is performed using contrast-enhanced computed tomography (CT). Nevertheless, recent advances in the field of hybrid imaging have made positron emission tomography/CT (PET/CT) and PET/magnetic resonance imaging (PET/MRI) as emerging potential noninvasive imaging tools for improved management of OC. Several studies have championed the role of PET/CT for the detection of recurrence and prognostication of OC. We provide a systematic review and meta-analysis of the latest publications regarding the role of molecular imaging in the management of OC. We retrieved 57 original research articles with one article having overlap in both diagnosis and staging; 10 articles (734 patients) regarding the role of PET/CT in diagnosis of OC; 12 articles (604 patients) regarding staging of OC; 22 studies (1429 patients) for detection of recurrence; and 13 articles for prognostication and assessment of treatment response. We calculated pooled sensitivity and specificity of PET/CT performance in various aspects of imaging of OC. We also discussed the emerging role of PET/MRI in the management of OC. We aim to give the readers and objective overview on the role of molecular imaging in the management of OC.

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