This study aimed to determine the effects of Breast Self-Examination (BSE) education and practice on knowledge, health beliefs, and compliance in nursing students. Participants were 172 students from 2 nursing colleges. They responded to questionnaires assessing knowledge, health beliefs and compliance within a 3-month interval. The experimental group participated in a 120-minute educational session. They were significant differences between groups in knowledge about BSE(t=21.18, p=<.001), health beliefs(t=3.69, p=<.001), and compliance(t=5.59, p=<.001) which indicates that education in breast cancer and BSE improves health beliefs and BSE compliance. Taking into consideration various clinical circumstances of based cancer and the characteristics of university students aged in their early 20s, follow-up studies need to focus on developing customized BSE educational programs thorough teaching methods using diverse media including You Tube, videos, and QR codes and verify their effectiveness.