Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders

Otto, Michael W.; Simon, Naomi M.; Wisniewski, Stephen R.; Miklowitz, David J.; Kogan, Jane N.; Reilly-Harrington, Noreen A.; Frank, Ellen; Nierenberg, Andrew A.; Marangell, Lauren B.; Sagduyu, Kemal; Weiss, Roger D.; Miyahara, Sachiko; Thas, M. E.; Sachs, Gary S.; Pollack, Mark H.

doi:10.1192/bjp.bp.104.007773

Cited by 192 publications

(176 citation statements)

References 27 publications

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“…In particular, with respect to BD, anxiety disorders are associated with earlier age of onset, poorer treatment response (Feske et al, 2000), exacerbated illness course and severity (Goodwin and Hoven, 2002;Boylan et al, 2004;Keller, 2006;Otto et al, 2006), and suicidality (Dilsaver and Chen, 2003). Previous studies have also demonstrated that anxiety disorders among youth are significant predictors of later BD in adulthood (Goodwin and Hamilton, 2002;Johnson et al, 2000;Kessler et al, 1997;Kim-Cohen et al, 2003;Perugi et al, 2001), and anxiety disorders predate BD among most youth with comorbid anxiety disorders and BD (Dickstein et al, 2005;Dilsaver and White, 1986;Masi et al, 2001;Wagner, 2006).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of bipolar I disorder among adults with primary youth‐onset anxiety disorders

Goldstein

Levitt

2007

Journal of Affective Disorders

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Objectives-It is of potentially great public health importance to determine whether youth-onset anxiety disorders are associated with increased prevalence of subsequent bipolar I disorder (BD) among adults, and to identify risk factors for BD in this population. Methods-The 2001-2002National Epidemiologic Survey on Alcohol and Related Conditions was used to identify respondents with social phobia, panic disorder, or generalized anxiety disorder that onset in youth (<19 years) and was not preceded by a major depressive, manic, or mixed episode (N=1,571; 572 males, 999 females). The prevalence of BD among subjects with, versus without, these youth-onset anxiety disorders was examined. Variables that could be associated with increased risk of BD among subjects with youth-onset anxiety disorders were examined, including conduct disorder, youth-onset substance use disorders (SUD), and family history of depression and/or alcoholism. Analyses were computed separately for males and females.Results-The prevalence of BD was significantly greater among adults with, versus without, primary youth-onset anxiety disorders for both males (15.9% vs 2.7%; χ2=318.4, df=1, p<0.001) and females (13.8% vs 2.9%; χ2=346.2, df=1, p<0.001). Youth-onset anxiety disorders remained significantly associated with BD after controlling for interceding major depression, and this was true for each of the specific anxiety disorders examined. Among males with youth-onset primary anxiety disorders, conduct disorder and loaded family history of depression were associated with significantly increased risk of BD. Among females, conduct disorder and loaded family history of alcoholism were associated with significantly increased risk of BD.Conclusions-The prevalence of BD was elevated among subjects with youth-onset primary anxiety disorders, particularly if comorbid conduct disorder was present. Future studies are needed to confirm these findings prospectively, and to develop preventive strategies for populations at risk.

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Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of bipolar I disorder among adults with primary youth‐onset anxiety disorders

Goldstein

Levitt

2007

Journal of Affective Disorders

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“…Among residual symptoms, insomnia and anxiety are most commonly observed and predict a poor course of bipolar disorder (Otto et al, 2006;Putnins et al, 2012); however, evidence for treatment options is limited. Insomnia and anxiety are typically treated with the adjunctive benzodiazepines, which risk abuse and dependency if used chronically (Uzun et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Baek

Nierenberg

Kinrys

2014

Aust N Z J Psychiatry

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Objectives: Patients with bipolar disorder frequently continue to experience residual anxiety and insomnia between mood episodes. In real-world practice, patients increasingly self-prescribe alternative medicines. Methods:We reviewed case reports, open-label, and placebo-controlled trials investigating the use of herbal medicines to treat anxiety and insomnia, and discussed their potential applications for bipolar disorder.Results: Eleven herbal medicines that have been studied in human subjects are included in this review. Mechanisms of action, efficacy, side effects, and drug-drug interactions are discussed. Based on currently available evidence, valerian seems to be the most promising candidate for insomnia and anxiety in bipolar disorder. Conclusions:Adjunctive herbal medicines may have the potential to alleviate these symptoms and improve the outcomes of standard treatment, despite limited evidence. Physicians need to have a more in-depth understanding of the evidence of benefits, risks, and drug interactions of alternative treatments.

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“…In our study the same relationship exists in the context of the comorbidities. Both co-morbid anxiety (Otto et al 2006) and personality disorders (George et al 2003) have been found to modify the course of bipolar disorder, which reflects in worse marital functioning as well and should be taken into consideration. What is interesting, both of these factors turned out to be insignificant in the context of dyadic cohesion.…”

Section: Discussionmentioning

confidence: 99%

Dyadic Adjustment Among Healthy Spouses of Bipolar I and Ii Disorder Patients

2017

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Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders

Cited by 192 publications

References 27 publications

Prevalence and correlates of bipolar I disorder among adults with primary youth‐onset anxiety disorders

Prevalence and correlates of bipolar I disorder among adults with primary youth‐onset anxiety disorders

Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder

Dyadic Adjustment Among Healthy Spouses of Bipolar I and Ii Disorder Patients

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