Prospect of early vascular tone and satellite cell modulations on white striping muscle myopathy

Abstract

Polyphasic myodegeneration potentially causes severe physiological and metabolic disorders in the breast muscle of fast-growing broiler chickens. To date, the etiology of recent muscle myopathies, such as the white striping ( WS ) phenotype, is still unknown. White striping–affected breast meats compromise the water holding capacity and predispose muscle to poor vascular tone, leading to the deterioration of meat qualities. Herein, this review article provides insight on the complexities around chicken breast myopathies: (i) the etiologies of WS occurrence in chicken; (ii) the metabolic changes that occur in WS defect in pectoralis major; and (iii) the interactions between breast muscle physiology and vascular tone. It also addressed the effects of nutritional supplements on muscle myopathies on chicken breast meats. Moreover, the review explored breast muscle biology focusing on the early preparation of satellite and vascular cells in fast-growth chicken breeds. Transcriptomics and histological analyses revealed poor vascularity in breast muscle of fast growth chickens. Thus, we suggest in ovo feeding of nutrients promoting vascularization and satellite cells replenishment as a potential strategy to enhance endothelium-derived nitric oxide availability to promote vascularization in the pectoralis major muscle region.

Early Phenotype Programming in Birds by Temperature and Nutrition: A Mini-Review

“…In ovo feeding is a more direct way to influence offspring phenotype. Several studies have reported the use of in ovo nutrient supplementation to reduce the hatch window and improve health, post-hatch immune status, hatchability, hatched chick weight, growth performance, and meat quality (Uni and Ferket, 2004;Wei et al, 2011;Kadam et al, 2013;Roto et al, 2016;Gao et al, 2017;Peebles, 2018;Taha-Abdelaziz et al, 2018;Jha et al, 2019;Kalantar et al, 2019;Ayansola et al, 2021). New in ovo strategies also aim to address new challenges such as finding alternatives to antibiotic use through probiotic injections (Oladokun and Adewole, 2020).…”

Restricted Feeding Regimens Improve White Striping Associated Muscular Defects In Broiler Chickens

“…On this premise, this study shows that 1.5h-IF reduced the ber diameter in the breast muscle region, which aligns with the meat quality criterion for improved meat tenderness. The idea has been that enlarged ber size predisposes the breast muscle region to poor vascularization and lipidosis, consequently leading to metabolic disorders that characterize severe hypertrophic muscle in broiler pectoralis major (14). The reduced muscle ber diameter in the 1.5h-IF group could promote vascular tone and ensure proper muscular development by increasing interstitial space for vascular tissues without signi cantly affecting relative breast weight in broiler chickens (38,39).…”

“…This voluntary feed consumption leads to excess ectopic fat deposit and enlarged muscle ber sizes that disrupt muscular compositions and decrease vascular density in the breast muscle region (13). Notably, these muscular defects contribute to the etiologies of WS-affected broiler's meat quality (14,15). To solve growth-related muscular myodegeneration, Velleman and colleagues altered the timing of feeding to elucidate the fate of fat deposit and adipogenic transcription factors expression in pectoralis major muscle (3).…”

Molecular Pathways and Key Genes Associated With Breast Width and Protein Content in White Striping and Wooden Breast Chicken Pectoral Muscle

“…Several years of studies led to an extensive description of phenotypic and molecular perturbations that characterize these abnormalities and that may underly their occurrence. Some speculations have been made to try elucidating the mechanisms underlying these defects (Boerboom et al, 2018;Velleman, 2020;Ayansola et al, 2021). Among them, recent studies have highlighted a possible role of the development of oxidative stress (Hubert and Athrey, 2022), mitochondrial dysfunction (Papah et al, 2017), and energy metabolism dysregulations (Papah and Abasht, 2019) in the cascade of events triggering the occurrence of WS and WB.…”