Coronavirus disease 2019 (COVID-19) is probably the most commonly heard word of the
last 12 months. The outbreak of this virus (SARS-CoV-2) is strongly compromising
worldwide healthcare systems, social behavior, and everyone’s lives. The early
diagnosis of COVID-19 and isolation of positive cases has proven to be fundamental in
containing the spread of the infection. Even though the polymerase chain reaction (PCR)
based methods remain the gold standard for SARS-CoV-2 detection, the urgent demand for
rapid and wide-scale diagnosis precipitated the development of alternative diagnostic
approaches. The millions of tests performed every day worldwide are still insufficient
to achieve the desired goal, that of screening the population during daily life.
Probably the most appealing approach to consistently monitor COVID-19 spread is the
direct detection of SARS-CoV-2 from exhaled breath. For instance, the challenging
incorporation of reliable, highly sensitive, and cost-efficient detection methods in
masks could represent a breakthrough in the development of portable and noninvasive
point-of-care diagnosis for COVID-19. In this perspective paper, we discuss the critical
technical aspects related to the application of breath analysis in the diagnosis of
viral infection. We believe that, if achieved, it could represent a game-changer in
containing the pandemic spread.