Prospect for anthelminthic plants in the Ivory Coast using ethnobotanical criteria

Diehl, Michelle Schalemberg; Atindehou, K. Kamanzi; Téré, Henri; Betschart, Bruno

doi:10.1016/j.jep.2004.07.012

Cited by 74 publications

(61 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Parasitic nematodes are a major threat to livestock production worldwide leading to huge economic losses (ADEMOLA; ELLOF, 2010), because of the support treatments and increased manpower that the infected animals require and because of the high mortality rate within flocks, especially in small ruminants (DIEHL et al, 2004). Anthelmintics have been used to minimize the losses caused by helminth infections.…”

Section: Introductionmentioning

confidence: 99%

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Macedo

Oliveira

Camurça-Vasconcelos

et al. 2013

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

In vitro effects of AbstractPhytotherapy can be an alternative for the control of gastrointestinal parasites of small ruminants. This study evaluated the efficacy of Alpinia zerumbet, Coriandrum sativum, Tagetes minuta and Lantana camara essential oils by two in vitro assays on Haemonchus contortus, an egg hatch test (EHT) and larval development test (LDT). No effect was observed for L. camara in the EHT. A. zerumbet, C. sativum and T. minuta essential oils exhibited a dose-dependent effect in the EHT, inhibiting 81.2, 99 and 98.1% of H. contortus larvae hatching, respectively, at a concentration of 2.5 mg mL -1 . The effective concentration to inhibit 50% (EC50) of egg hatching was 0.94, 0.63 and 0.53 mg mL -1 for A. zerumbet, C. sativum and T. minuta essential oils, respectively. In LDT, L. camara, A. zerumbet, C. sativum and T. minuta at concentration of 10 mg mL -1 inhibited 54.9, 94.2, 97.8 and 99.5% of H. contortus larval development, presenting EC50 values of 6.32, 3.88, 2.89 and 1.67 mg mL -1 , respectively. Based on the promising results presented in this in vitro model, it may be possible use of these essential oils to control gastrointestinal nematodes. However, their anthelmintic activity should be confirmed in vivo.Keywords: Phytotherapy, anthelmintic, gastrointestinal nematodes. ResumoFitoterapia pode ser uma alternativa para o controle de parasitas gastrintestinais de pequenos ruminantes. Este estudo avaliou a eficácia dos óleos essenciais de Alpinia zerumbet, Coriandrum sativum, Tagetes minuta e Lantana camara sobre Haemonchus contortus através de dois testes in vitro, teste de eclosão dos ovos (TEO) e teste de desenvolvimento larval (TDL). Nenhum efeito foi observado para L. camara no TEO. Os óleos essenciais de A. zerumbet, C. sativum e T. minuta exibiram um efeito dose dependente no TEO inibindo a eclosão das larvas de H. contortus em 81,2, 99 e 98,1%, respectivamente, na concentração de 2,5 mg mL -1 . A concentração efetiva para inibir 50% (CE50) da eclosão dos ovos foi de 0,94, 0,63 e 0,53 mg mL -1 para os óleos essenciais de A. zerumbet, C. sativum e T. minuta, respectivamente. No TDL, 10 mg mL -1 de L. camara, A. zerumbet, C. sativum e T. minuta inibiram em 54,9, 94,2, 97,8 e 99,5% do desenvolvimento larvar, apresentando valores de CE50 de 6,32, 3,88, 2,89 e 1,67 mg mL -1 , respectivamente. Com base nos resultados promissores apresentados neste modelo in vitro, pode ser possível a utilização destes óleos essenciais para controlar os nematoides gastrintestinais. No entanto, a sua atividade anti-helmíntica deve ser confirmada in vivo.Palavras-chave: Fitoterapia, anti-helmínticos, nematoides gastrintestinais.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Macedo

Oliveira

Camurça-Vasconcelos

et al. 2013

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

show abstract

“…These parasites are responsible for severe weight loss, diarrhea, anemia and early mortality, and all of these cause production losses, especially in small ruminants (DIEHL et al, 2004). Synthetic anthelmintics have been used to minimize the losses caused by helminth infections.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Eucalyptus citriodora essential oil on goat gastrointestinal nematodes

Macedo

Beviláqua

Oliveira

et al. 2011

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

Phytotherapy may be an alternative strategy for controlling gastrointestinal parasites. This study evaluated the anthelmintic efficacy of Eucalyptus citriodora essential oil (EcEO). The in vitro effects of EcEO were determined through testing the inhibition of egg hatching and larval development of Haemonchus contortus. EcEO was subjected to acute toxicity testing on mice, orally and intraperitoneally. The in vivo effects of EcEO were determined by the fecal egg count reduction test (FECRT)

show abstract

“…Its antiplasmodial, 1,2) antitrypanosomal 3) and anthelmintic 4) activities have already been tested. Its roots are also used by traditional healers as a remedy for sexual dysfunction.…”

mentioning

confidence: 99%

Two New Quinoline and Tris(4-hydroxycinnamoyl)spermine Derivatives from Microdesmis keayana Roots

Zamblé

Hennebelle

Şahpaz

et al. 2007

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Microdesmis keayana LÉONARD (Pandaceae) is a tropical shrub, the leaves of which are used in the Ivory Coast against malaria and some other parasites. Its antiplasmodial, 1,2) antitrypanosomal 3) and anthelmintic 4) activities have already been tested. Its roots are also used by traditional healers as a remedy for sexual dysfunction. An aqueous extract of these roots, recently tested, exhibited vasorelaxing properties, explained by an increase in nitric oxide (NO) in the vascular bed, via antioxidant properties and stimulation of endothelial nitric oxide synthase (eNOS) mRNA expression.5) In a previous paper three new tris(4-hydroxycinnamoyl)spermidines have been reported. 6) Continuing investigations on the roots of M. keayana have now led to the isolation and structural elucidation of two other new compounds, one quinoline derivative xanthoquininamide 1 and one tris(4-hydroxycinnamoyl)spermine keayanine 2. Results and DiscussionXanthoquininamide (1) was obtained as a pale yellow powder soluble in methanol. It showed an [MϩH] ϩ peak at m/z 189 in the ESI-MS data. The 1 H-NMR spectrum in MeOD was very simple and all chemical shifts and couplings which were observed between d H 7.3 and d H 8.8, including a not-so-common Jϭ4.5 Hz between H-2 and H-3, 7) were consistent for a quinoline derivative which was substituted on C-6 or C-7 (because of the ABX system) and on C-4. Mono-( 1 H and 13 C) and bidimensional (COSY, HMQC, HMBC) NMR experiments, as well as comparison with data of previously described quinine-like alkaloids, 8) made it possible to establish the structure of 1 as 6-hydroxyquinoline-4-carboxamide.1 H-and 13 C-NMR chemical shifts are given in Table 1. To our knowledge, this is the first report of both the natural occurrence of 1 and of its complete spectroscopic data, although it has already been synthesised from xanthoquininic acid by amidification. 9)Compound 2 was characterized both by ESI-MS and NMR data. In the electrospray mass spectrum, a [MϩH] ϩ peak was observed at m/z 701. Typical fragments were observed on ESI-MS spectrum at m/z 147 and m/z 177, corresponding to one coumaroyl and two feruloyl residues respectively, according to the relative heights of both signals. The subtraction of these three elements from the molecular mass of the compound (m/z 700) gave a mass of 199, compatible with a tri-substituted spermine. The positions of all three acyl moieties were determined by ESI-MS (see Fig. 2 Purification of a Microdesmis keayana hydromethanolic root extract led to the isolation of two new natural compounds, xanthoquininamide (6-hydroxyquinoline-4-carboxamide) and tris(4-hydroxycinnamoyl)spermine (N 5 -(p-coumaroyl)-N 1 ,N 14 -diferuloylspermine) which was named keayanine. Their structures were determined using spectroscopic analyses (ESI-MS, 1D-and 2D-NMR).

show abstract

Prospect for anthelminthic plants in the Ivory Coast using ethnobotanical criteria

Cited by 74 publications

References 44 publications

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Evaluation of Eucalyptus citriodora essential oil on goat gastrointestinal nematodes

Two New Quinoline and Tris(4-hydroxycinnamoyl)spermine Derivatives from Microdesmis keayana Roots

Contact Info

Product

Resources

About