Prosopis juliflora as a new cosmetic ingredient: Development and clinical evaluation of a bioactive moisturizing and anti-aging innovative solid core

Damasceno, Gabriel A.B.; Barreto, Stella Maria Andrade Gomes; Reginaldo, Fernanda Priscila Santos; Souto, Augusto Lopes; Fernandes-Negreiros, Marília Medeiros; Viana, Rony Lucas Silva; Pinto, Talita Katiane de Brito; Daher, Cláudia Cecilio; Silva-Filho, Jean A.A.; Moura, Rafael A.O.; Silva, Milena A.; Silveira, Walteçá Louis Lima da; Medeiros, Andreza A.; Ostrosky, Elissa Arantes; Veríssimo, Lourena Mafra; Sassaki, Guilherme L.; Lopes, Patrícia Santos; Sales, V.S.F.; Rocha, Hugo Alexandre Oliveira; Cavalheiro, Alberto José; Giordani, Raquel Brandt; Ferrari, Márcio

doi:10.1016/j.carbpol.2020.115854

Cited by 11 publications

(5 citation statements)

References 26 publications

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“…Finally, the results evidence that the essential oils -especially from lavender and melaleuca -can accumulate in the upper layers of the stratum corneum and improve the skin barrier and some skin structural properties, as observed for the formulation with four essential oils. Other studies [57,58] already correlated the reduction in the skin barrier properties with the cytotoxic effect, different for what we observed in this study, reinforcing the safety of the studied essential oils in combination and the potential to be applied in cosmetic products.…”

Section: In Vivo Efficacy Studysupporting

confidence: 53%

Safety and efficacy of combined essential oils for the skin barrier properties: In vitro, ex vivo and clinical studies

Infante

Campos

et al. 2022

Intern J of Cosmetic Sci

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Objective: To evaluate the safety and the synergistic effects of tea tree, lavender, eucalyptus and tangerine essential oils in combination on the skin using in vitro, ex vivo and clinical studies. Methods:The phototoxicity was predicted using 3T3 neutral red uptake phototoxicity test (OECD TG 432). Skin penetration was evaluated by confocal Raman microspectroscopy using direct application of essential oils to pig ears. For the clinical studies, 40 participants were enrolled and randomized in three groups:(1) lavender, eucalyptus and tangerine, (2) the same essential oils plus melaleuca and (3) placebo group. The skin was evaluated by noninvasive techniques before and after a 90-day period of topical use. Results:The essential oils were non-phototoxic, but the tangerine oil showed dose-dependent cytotoxicity (IC50: 33.1 µg/ml), presenting 35% of penetration in the viable epidermis. On the contrary, 17.7 µg/ml in combination was applied per day in the clinical study and the penetration rate for the combinations (10%, 1.77 µg/ml achieving the viable epidermis) guaranteed the safety, since in the clinical study, the application of the four essential oils improved skin barrier and morphologic skin characteristics, as well as increased skin hydration and decreased sebum levels, with no unwanted effects reported.Conclusions: All essential oils studied were considered non-cytotoxic or nonphototoxic separately except tangerine, which present a dose-dependent cytotoxicity. Finally, the essential oils in combination in an appropriate amount were safe and effective in the improvement of the hydrolipidic balance and morphological properties of the skin.

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Section: In Vivo Efficacy Studysupporting

confidence: 53%

Safety and efficacy of combined essential oils for the skin barrier properties: In vitro, ex vivo and clinical studies

Infante

Campos

et al. 2022

Intern J of Cosmetic Sci

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“…Moreover, after 30 days of use, the formulation reduced transepidermal water loss, consequently reducing the appearance of wrinkles. 175 Thus, investigations of the possible formulations based on these polysaccharides should be encouraged. It is expected that in the future, after adequate testing in vivo and human volunteers, the plant polysaccharide-based formulations can apply to not only the skin but also the human body, including the circulatory, respiratory, digestive, immune, nervous, excretory, muscular, endocrine, and skeletal systems for clinical use with therapeutic and preventive purposes.…”

Section: Application Spotlight: Plant Polysaccharide-based Formulatio...mentioning

confidence: 99%

“…A formulation containing Prosopis juliflora fruit polysaccharide was obtained through the wet granulation process, and this formulation retained a higher water content in the stratum corneum than the controls on the skin of human volunteers. Moreover, after 30 days of use, the formulation reduced transepidermal water loss, consequently reducing the appearance of wrinkles …”

Section: Application Spotlight: Plant Polysaccharide-based Formulatio...mentioning

confidence: 99%

Advances in Plant Polysaccharides as Antiaging Agents: Effects and Signaling Mechanisms

Deng

Wang

et al. 2023

J. Agric. Food Chem.

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Aging refers to the gradual physiological changes that occur in an organism after reaching adulthood, resulting in senescence and a decline in biological functions, ultimately leading to death. Epidemiological evidence shows that aging is a driving factor in the developing of various diseases, including cardiovascular diseases, neurodegenerative diseases, immune system disorders, cancer, and chronic low-grade inflammation. Natural plant polysaccharides have emerged as crucial food components in delaying the aging process. Therefore, it is essential to continuously investigate plant polysaccharides as potential sources of new pharmaceuticals for aging. Modern pharmacological research indicates that plant polysaccharides can exert antiaging effects by scavenging free radicals, increasing telomerase activity, regulating apoptosis, enhancing immunity, inhibiting glycosylation, improving mitochondrial dysfunction regulating gene expression, activating autophagy, and modulating gut microbiota. Moreover, the antiaging activity of plant polysaccharides is mediated by one or more signaling pathways, including IIS, mTOR, Nrf2, NF-κB, Sirtuin, p53, MAPK, and UPR signaling pathways. This review summarizes the antiaging properties of plant polysaccharides and signaling pathways participating in the polysaccharide-regulating aging process. Finally, we discuss the structure–activity relationships of antiaging polysaccharides.

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“…The longterm skin hydration effect of P. juliflora leaves extract was able to maintain the water content of stratum corneum for 30 days with a decrease in water content of only 0.4%. Therefore, P. juliflora leaves extract can be considered a natural moisturizing agent in skin care products 43 .…”

Section: Prosopis Juliflora Leavesmentioning

confidence: 99%

Potential of Natural Based-Skincare Cosmetic Ingredients for Naturally Glowing Skin

Oktaviani,

Susilawati,

Tjitraresmi

et al. 2023

Borneo J Pharm

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The use of skincare products is the primary need in modern society. There is an increase in awareness of maintaining beauty and healthy skin, as well as the desire to have naturally glowing, healthy skin, which is in line with the rise in the use of cosmetics, especially skincare products. Nature provides many plants and marine resources (such as algae) that can be utilized as essential ingredients for cosmetics preparations with various benefits such as cleansers, toners, moisturizers, and sun protectors, a primary series of skincare products to gain naturally glowing, healthy skin. This review aims to provide information about plants and marine algae that can be used as skincare ingredients, their phytochemical contents, and their function in cosmetics to achieve naturally glowing skin. Various plants and marine algae categorized based on their benefits as skincare have great potential to be developed as ingredients in cosmetic preparations. The content of phytochemical compounds in these plants and marine algae supports these benefits. Each skincare category has major phytochemical compounds that play a role in providing these benefits.

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Prosopis juliflora as a new cosmetic ingredient: Development and clinical evaluation of a bioactive moisturizing and anti-aging innovative solid core

Cited by 11 publications

References 26 publications

Safety and efficacy of combined essential oils for the skin barrier properties: In vitro, ex vivo and clinical studies

Safety and efficacy of combined essential oils for the skin barrier properties: In vitro, ex vivo and clinical studies

Advances in Plant Polysaccharides as Antiaging Agents: Effects and Signaling Mechanisms

Potential of Natural Based-Skincare Cosmetic Ingredients for Naturally Glowing Skin

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