Prosocial Effects of Nonpsychotropic <i>Cannabis sativa</i> in Mice

Mastinu, Andrea; Ascrizzi, Roberta; Ribaudo, Giovanni; Bonini, Sara Anna; Premoli, Marika; Aria, Francesca; Maccarinelli, Giuseppina; Gianoncelli, Alessandra; Flamini, Guido; Pistelli, Luisa; Memo, Maurizio

doi:10.1089/can.2021.0017

Cited by 14 publications

(17 citation statements)

References 61 publications

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“…C. pepo seeds oil has no cholesterol, and is rich in ω9, and ω6 acids, fatty acids with more than 40% oleic acid, 33.1% linoleic acid, and 14.7% palmitic acid, and is effective in relieving joint pain, especially in chronic conditions and post-menopausal bone density [2,3]. The quantity, and quality of secondary metabolites such as alkaloids, glycosides, steroids and, essential oils in medicinal plants are affected by environmental factors including drought stress, nutrition, and plant growth regulators [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Physiological and Qualitative Response of Cucurbita pepo L. to Salicylic Acid under Controlled Water Stress Conditions

et al. 2022

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Limited water stress is one of the most important environmental stresses that affect the growth, quantity and quality of agronomic crops. This study was undertaken to investigate the effect of foliar applied salicylic acid (SA) on physiological responses, antioxidant enzymes and qualitative traits of Cucurbita pepo L. Plants exposed to water-stressed conditions in two years of field studies. Irrigation regimes at three soil matric potential levels (−0.3, −1.2 and −1.8 MPa) and SA at four levels (0.0, 0.5, 1.0 and 1.5 mg/L) were considered as main plot and sub-plots, respectively. The soil matric potential values (MPa) was measured just before irrigation. Results showed that under water stressed conditions alone, the amounts of malondialdehyde (MDA), hydrogen peroxide (H2O2) and ion leakage were higher compared with control treatment. However, spraying of SA under both water stress and non-stress conditions reduced the values of the above parameters. Water stress increased CAT, APX and GR enzymes activity. However foliar application of SA led to the decrease of CAT, APX and GR under all soil matric potential levels. The amount of carbohydrates and fatty acids increased with the intensity of water stress and SA modulated this response. By increasing SA concentration both in optimum and stress conditions, saturated fatty acids content decreased. According to our data, the SA application is an effective approach to improve pumpkin growth under water stress conditions.

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Section: Introductionmentioning

confidence: 99%

Physiological and Qualitative Response of Cucurbita pepo L. to Salicylic Acid under Controlled Water Stress Conditions

et al. 2022

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“…( Linck et al, 2010 ; Russo, 2011 ; De Sousa et al, 2015 ; Lewis et al, 2018 ; Nuutinen, 2018 ; Ferber et al, 2019 )). Other studies have demonstrated the role of terpenes in augmenting cannabis anxiolytic profile ( Kamal et al, 2018 ; Mastinu et al, 2022 ). However, given the low, plausibly sub-therapeutic concentrations of the terpenes in these studies, an alternative mechanism is suggested here.…”

Section: Discussionmentioning

confidence: 99%

“…CBD further acts as an antidepressant and an anxiolytic agent, via 5-HT1a modulation ( Linge et al, 2016 ), and most importantly, elevates AEA levels, as a modulator of its degraded enzyme, FAAH (Fatty acid amide hydrolase). A recent study ( Mastinu et al, 2022 ) had demonstrated that treating mice with CBD-rich cannabis extract results in increased social and reduced nonsocial behaviors. CBD has a very high toxicity threshold in humans and other species, and no teratogenic or mutagenic effects have been found to be induced by CBD ( Larsen, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report

Raz¹,

Heller²,

Lombardi³

et al. 2022

Front. Pharmacol.

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Cannabidiol (CBD) rich products are successfully used in some countries for treating symptoms associated with autism spectrum disorder (ASD). Yet, CBD provides insufficient intervention in some individuals, or for some characterizing symptoms of ASD, raising the need for improved compositions. The current study presents a case wherein pure CBD was sufficient for treating ASD during childhood and early adolescence. However, it became insufficient during puberty accompanied by increased hyperactivity, agitation, and frequent severe aggressive behavior. Increasing the CBD dose did not result in significant improvement. Enriching the pure CBD with a carefully selected blend of anxiolytic and calming terpenes, resulted in gradual elimination of those aggressive events. Importantly, this was achieved with a significantly reduced CBD dose, being less than one-half the amount used when treating with pure CBD. This case demonstrates a strong improvement in efficacy due to terpene enrichment, where pure CBD was not sufficient. Combined with terpenes’ high safety index and the ease with which they can be incorporated into cannabinoid-containing products, terpene-enriched CBD products may provide a preferred approach for treating ASD and related conditions. The careful selection of terpenes to be added enables maximizing the efficacy and tailoring the composition to particular and changing needs of ASD subjects, e.g., at different times of the day (daytime vs nighttime products).

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“…Plants produce secondary metabolites used by humans for therapeutic, food, and aesthetic purposes [10][11][12][13][14][15][16][17][18][19]. Indeed, garlic's main characteristic is the distinct flavor of its cloves, which is a result of complex biochemical reactions [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…The enzymatic pyruvic acid represents the remaining capacity to produce flavor. The reduction in pyruvic acid content is attributed to the partial inactivation of alliinase, and the enzymatic and non-enzymatic destruction of flavor precursors [9,17]. Genetic diversity is an important component of biodiversity, and refers to inherited changes at the molecular level, and causes variation in DNA sequence, biochemical, and physiological properties [19,29].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Botanical Aspects of Allium sativum L. Sowing

Ammarellou

Yousefi

Heydari

et al. 2022

BioTech

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The main aim of this study was to evaluate the yield and compliance of selected Iranian garlic (Allium sativum L.) cultivars, including Tuyserkan (TSN), Heydareh (HDH), Mouien (MUN), and Taroom (TRM), during two growing seasons. The TRM cultivar germination rate is higher than the other cultivars studied. The TRM cultivars have quite remarkable values for the dry weight, fresh weight, stem diameter, and the number of leaves present. The fresh weight and dry weight of the TRM cultivar for the second year are 33.8 t/ha and 16.7 t/ha, respectively. However, on average, the HDH cultivar is the tallest plant in the experiments. Average pyruvic acid content in fresh samples of the TRM and HDH cultivars is 78 µm/gfw and 69.3 µm/gfw, respectively. It is observed that there are remarkable differences in the level of pyruvic acid between the different cultivars. The growth, development, and yield of plants are highly dependent on their genetic characteristics; in this experiment, the TRM cultivar shows a good yield (16.7 t/ha), and the evaluated characteristics improve compared to the other cultivars studied, which could be due to the high compatibility of this cultivar to the environmental conditions of the study. The excellent performance on the yield of TRM makes this cultivar more appreciable on a commercial level.

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Prosocial Effects of Nonpsychotropic Cannabis sativa in Mice

Cited by 14 publications

References 61 publications

Physiological and Qualitative Response of Cucurbita pepo L. to Salicylic Acid under Controlled Water Stress Conditions

Physiological and Qualitative Response of Cucurbita pepo L. to Salicylic Acid under Controlled Water Stress Conditions

Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report

Biochemical and Botanical Aspects of Allium sativum L. Sowing

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