Prosexual drugs: Empirical status of the ?new aphrodisiacs?

Rosen, Raymond C.; Ashton, Adam Keller

doi:10.1007/bf01543299

Cited by 68 publications

(33 citation statements)

References 64 publications

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“…In addition, SJE significantly increased the incidence of mounting (144.43%, 266.67% and 300% respectively) and intromission (100%, 158.84% and 200.04% respectively) in a dose-dependent manner. MF and IF are considered as the indices of both libido and potency (Rosen and Ashton, 1993;Ratnasooriya and Dharmasiri, 2000). This is an indication that the test drug possesses a sexual function improving effect.…”

Section: Male Sexual Behaviours In Mating Testsmentioning

confidence: 99%

The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

Owiredu¹,

Nafiu²,

Amissah³

et al. 2007

Jnl Sci Tech

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Roots of S. jollyanum are considered as sexual stimulant in Ghanaian traditional medicine. The present study is aimed at investigating the effect of an ethanolic extract of the root of S. jollyanum on sexual behaviour of male mice and reproductive hormones in male rats. Extract of S. jollyanum (100, 300 and 1000 mg/kg p.o) stimulated mounting and mating behaviour by increasing mounting frequency, intromission frequency and prolonged ejaculation latency. In addition, a decrease in mounting latency, intromission latency and postejaculatory interval was observed. These observations were indicative of increased libido and enhanced sexual behaviour. However, the dose-response curves of some of the parameters measured (attempted mounts, mounting frequency, anogenital sniffing and penile licking) were U-shaped i.e. the effects observed were absent at higher doses. Also the effect of the extract on FSH, LH, prolactin and testosterone levels in rats were determined at weekly intervals for three weeks. Levels of testosterone were increased 4-fold by the third week and there was about 30% increase in FSH levels by the second week which dropped by the third week. Surprisingly, LH levels were reduced by the second week with no significant change in levels of prolactin. These results suggest that there may be more than one mechanism of action of the extract. The immediate increase in sexual behaviour by extract of S. jollyanum may be due to a central stimulatory effect whilst long-term effect might be due to increased testosterone levels. The stimulation of sexual behaviour in male mice and rats supports the claims for its traditional usage in sexual disorders.

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Section: Male Sexual Behaviours In Mating Testsmentioning

confidence: 99%

The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

Owiredu¹,

Nafiu²,

Amissah³

et al. 2007

Jnl Sci Tech

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“…[7][8][9] Several types of drugs have been developed for the treatment of erectile dysfunction, while other agents have been suggested for the treatment of inhibition of sexual desire. [10][11][12][13][14] However, few studies on the origin of these disturbances have investigated psychosocial factors such as unemployment. The increasing risk of erectile dysfunction has been correlated with diabetes, coronary heart disease and smoking.…”

Section: About 30 Million Men In the Unitedmentioning

confidence: 99%

The impact of psychosocial factors on the risk of erectile dysfunction and inhibition of sexual desire in a sample of the Brazilian population

et al. 2005

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CONTEXT: Sexual dysfunctions can have origins in physical, psychological and psychosocial factors. OBJECTIVE: To describe the frequency of erectile dysfunction (ED) and female inhibition of sexual desire (ISD) in a Brazilian sample, and to estimate the risks of these dysfunctions. TYPE OF STUDY: Non-random survey. SETTING: Ten Brazilian cities. METHODS: 2,835 subjects (53% women) aged over 18 years answered a questionnaire about their general health and sex life. The chi-squared test and multivariate logistic regression were used. Values of p < 0.05 were considered significant. RESULTS: The women's average age was 36.6 years (± 13.3) and the men's was 39.5 (± 13.3). 14.7% of men presented moderate/complete ED and 34.6% of women presented ISD. Depression was mentioned by 16.8% of men and 29.7% of women. The chances of having ED and ISD were higher for subjects who had had lower school attainment. Lack of a job and depression gave rise to 1.5 times (95% CI: 1.0 - 2.3) and 1.9 times (95% CI: 1.2 - 3.0) greater chances of ED respectively. Compared with men aged up to 25 years, those aged 41-60 had 1.9 times (95% CI: 1.0 - 3.4) and those aged 61 and over had 5.4 times (95% CI: 2.3 - 12.6) greater risk of ED. For women, lack of a job gave rise to 1.5 times (95% CI: 1.1 - 1.9) greater chance of ISD; depression was not associated with higher risk. Compared with women aged up to 25 years, those aged 41-60 and 61 or over had, respectively, 2.9 times (95% CI: 2.0 - 4.1) and 7.5 times (95% CI: 3.0 -18.6) greater risk of ISD. DISCUSSION: Increasing unemployment has affected the whole population, but especially those with lower levels of school attainment. Such levels are positively linked with presence of sexual dysfunctions. CONCLUSION: Lack of jobs, age and low school attainment are risks for the sexual dysfunctions studied. Depression increased the risk of ED but not female ISD.

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“…Tel: +27159628186; Cell: +27760952916 Fax: 27 15 962 8648. drive or libido (Rosen and Ashton, 1993). Substances often used as aphrodisiac cross the blood brain barrier and mimic or stimulate some area of sexual arousal in the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Aphrodisiac properties of some Zimbabwean medicinal plants formulations

Gundidza¹,

Mmbengwa²,

Magwa³

et al. 2009

Afr. J. Biotechnol.

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The aim of the present study was to determine the effects of formulations composed of Mondia whitei, Ekebergia capansis, aloe tincture (Aloe exelsa) and pumpkin seed (Cucurbita pepo) on sexual behaviour of inexperienced male rats. Male rats were treated orally with ethanol extracts of M. whitei and E. capensis, aloe tincture (from aloe juice) and pumpkin seed powder. The sexual behaviour of the rats treated with extracts was compared with those treated with 100 µg of testosterone as the positive control and those receiving normal rat feed as negative control. The receptivity of the females was rendered homogeneous with daily dose of estadiol benzoate. The sexual behaviour of the rats were observed over one ejaculatory phase for five consecutive days. The results showed a dose dependent increase in sexual arousability (decreased mounting latency), copulatory efficiency (decreased intercoupulatory interval) and improved sexual sensation (increased in neuromotor activity) for the rats treated with M. whitei and E. capensis, aloe and pumpkin seeds showing an increase in sexual performance in terms of intromissions and ejaculatory latency which also improved sexual sensation and coupulatory efficiency. The formulations of plants under investigation showed significant aphrodisiac properties.

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Prosexual drugs: Empirical status of the ?new aphrodisiacs?

Cited by 68 publications

References 64 publications

The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

The impact of psychosocial factors on the risk of erectile dysfunction and inhibition of sexual desire in a sample of the Brazilian population

Aphrodisiac properties of some Zimbabwean medicinal plants formulations

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