Propylene oligomers: extraction methods and characterization by FTIR, HPLC, and SEC

Mansouri, H. El; Yagoubi, Najet; Scholler, D.; Feigenbaum, Alexandre; Ferrier, D.

doi:10.1002/(sici)1097-4628(19990118)71:3<371::aid-app2>3.0.co;2-m

Cited by 7 publications

(1 citation statement)

References 13 publications

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“…Indeed, oligomers are known to be preferentially localized in the external layers of the polymer. 30 In addition, they are relatively unstable and reactive molecules. Thus, oxidation might have occurred preferentially on these compounds and led to their degradation (scission).…”

Section: Hydrolytic Stabilitymentioning

confidence: 99%

Plasma-based sterilization: Effect on surface and bulk properties and hydrolytic stability of reprocessed polyurethane electrophysiology catheters

Lerouge

Guignot

Tabrizian

et al. 2000

J. Biomed. Mater. Res.

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Plasma-based sterilization is a promising alternative to ethylene oxide (EO) for reprocessing of electrophysiology catheters. To assess its safety in terms of material damage, modifications of surface and bulk properties as well as hydrolytic stability of sterilized catheters were evaluated. Polyurethane (PU) single-use electrophysiology catheters were subjected to one, five, and ten sterilization cycles by Sterrad-100S and Plazlyte, as well as by pure EO for comparison. Surface analysis techniques (ATR-FTIR, XPS, DCA) showed oxidation limited to the near-surface layer induced by both plasma-based sterilizers, whereas EO induced slight but deeper alkylation. Using bulk analysis techniques (RP-HPLC, SEC), oligomer alteration was observed after all three sterilization techniques, without modification of molecular weights. Hydrolytic stability of catheters was slightly changed by plasma-based sterilization, with a small increase in released oligomers. Finally, although Plazlyte and Sterrad are both plasma-based techniques, they induced different impacts on catheters, such as the degradation of an additive with Sterrad, and a clear difference in coloration with Plazlyte.

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Section: Hydrolytic Stabilitymentioning

confidence: 99%

Plasma-based sterilization: Effect on surface and bulk properties and hydrolytic stability of reprocessed polyurethane electrophysiology catheters

Lerouge

Guignot

Tabrizian

et al. 2000

J. Biomed. Mater. Res.

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In vitro cytotoxicity testing of AB‐polymer networks based on oligo(ϵ‐caprolactone) segments after different sterilization techniques

Rickert

Lendlein²,

Schmidt

et al. 2003

J Biomed Mater Res

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Recently developed versatile biodegradable polymeric biomaterial offer new therapeutic options in numerous medical fields. Biocompatibility is a crucial requirement for the biomedical application of biomaterials, including the sterilization of these materials with the use of accepted protocols. Ethylene-oxide (EO) and low-temperature plasma (LTP) sterilization are frequently used low-temperature sterilization technologies for heat-sensitive materials. The agarose diffusion assay is a recommended cell-screening test to assess the cytotoxicity of biomaterials in vitro. The sensitivity of the agarose assay can be increased by using a modified computer-based image-analysis system. The influence of EO and LTP sterilization on the cytotoxicity of a versatile polymer system of shape-memory polymer networks based on oligo (epsilon-caprolactone) dimethacrylate and n-butyl acrylate was investigated. Statistically significant differences in the rate of cell lysis after EO and LTP sterilization of the polymer samples were detected by using this modified quantification system. The influence of the different sterilization techniques on the cytotoxicity of the polymeric material, as well as the clinical relevance of the described differences, are discussed.

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Results of Biocompatibility Testing of Novel, Multifunctional Polymeric Implant Materials In-Vitro and In-Vivo

Rickert

Fuhrmann

Hiebl

et al. 2010

Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

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Propylene oligomers: extraction methods and characterization by FTIR, HPLC, and SEC

Cited by 7 publications

References 13 publications

Plasma-based sterilization: Effect on surface and bulk properties and hydrolytic stability of reprocessed polyurethane electrophysiology catheters

Plasma-based sterilization: Effect on surface and bulk properties and hydrolytic stability of reprocessed polyurethane electrophysiology catheters

In vitro cytotoxicity testing of AB‐polymer networks based on oligo(ϵ‐caprolactone) segments after different sterilization techniques

Results of Biocompatibility Testing of Novel, Multifunctional Polymeric Implant Materials In-Vitro and In-Vivo

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