Propyl Gallate

Nguyen, Van Hai; Le, Minh Ngoc; Nguyen, Hoa B.; Ha, Kieu Oanh; Pham, Thai Ha Van; Nguyen, Thi Hong Hanh; Dao, Nguyet Suong Huyen; Nguyen, Dinh Luyen; Trinh, Nguyen Trieu

doi:10.3390/m1201

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…Propyl gallate, an antioxidant used in the food industry ( Nguyen et al, 2021 ), was significantly higher in the FF group. Propyl gallate is found in corn, a major component of the experimental formula feed.…”

Section: Discussionmentioning

confidence: 98%

Multi-tissue metabolomic profiling reveals potential mechanisms of cocoon yield in silkworms (Bombyx mori) fed formula feed versus mulberry leaves

Chen

et al. 2022

Front. Mol. Biosci.

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Use of formula feed (FF) for silkworms for all instars, has promoted transformation and progress in traditional sericulture. However, the cocoon yield of FF silkworms has failed to reach that of silkworms fed mulberry leaves (ML). The biological mechanisms underlying this phenomenon have not been well described. This study aimed to identify metabolic mechanisms and potential biomarkers relating to the poor cocoon yield of FF silkworms. In this study, silkworms received treatments of either ML (ML group) or FF (FF group) for all instars. At the 3rd day of the 5th instar, the midgut (MG), hemolymph (HL) and posterior silk gland (PSG) were collected for the metabolome profiles detection. The remaining silkworms were fed ML or FF until cocooning for investigation. The whole cocoon yield (WCY) was significantly higher in the FF group than the ML group (p < 0.05), whereas the cocoon shell weight (CSW) and cocoon shell rate (CSR) were significantly lower in the FF group (p < 0.05). A total of 845, 867 and 831 metabolites were qualified and quantified in the MG, HL and PSG of the FF silkworms, respectively. Correspondingly, 789, 833 and 730 metabolites were quantified in above three tissues of the ML group. Further, 230, 249 and 304 significantly different metabolites (SDMs) were identified in the MG, HL and PSG between the FF and ML group, respectively. Eleven metabolic pathways enriched by the SDMs were mutual among the three tissues. Among them, cysteine and methionine metabolism, arginine biosynthesis, and arginine and proline metabolism were the top three pathways with the highest impact value in the PSG. Six biomarkers were obtained through biomarker analysis and Pearson correlation calculation. Among them, homocitrulline, glycitein, valyl-threonine, propyl gallate and 3-amino-2,3-dihydrobenzoic acid were positively correlated with WCY, but negatively correlated with CSW and CSR (p < 0.05). An opposite correlation pattern was observed between 3-dimethylallyl-4-hydroxyphenylpyruvate and the three cocoon performance traits. Overall, three key metabolic pathways and six biomarkers associated with cocoon yield were interpreted, and should provide directions for formula feed optimization in factory-raised silkworms.

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Section: Discussionmentioning

confidence: 98%

Multi-tissue metabolomic profiling reveals potential mechanisms of cocoon yield in silkworms (Bombyx mori) fed formula feed versus mulberry leaves

Chen

et al. 2022

Front. Mol. Biosci.

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“…De fato, a lipase LPP tem sido amplamente empregada na produção industrial de enantiômeros para as indústrias de química fina e farmacêutica (Mendes, Oliveira & Castro, 2012). Neste sentido, estes resultados podem contribuir para a ampliação de sua aplicação em outros processos industriais visto que a produção de ésteres de ácido gálico ainda é preferencialmente realizada pela rota química empregando catalisadores homogêneos como ácidos inorgânicos (HClO4, HCl, H2SO4) e temperaturas de reação entre 50°C e 100°C (Nguyen et al, 2021). Este estudo mostra que é possível a adoção de um processo menos agressivo e ambientalmente correto usando uma lipase de baixo custo na produção de ésteres lipofílicos como galato de isoamila, pois foram requeridas condições brandas de temperatura (40°C).…”

Section: Seleção Da Fonte De Lipase Para Produção Enzimática De Galat...unclassified

Efeito Da Fonte De Lipase Na Produção De Um Éster De Ácido Gálico Por Esterificação Em Meio De Solvente

Passari

Mendes

et al. 2022

HOLOS

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O presente trabalho teve como objetivo a produção enzimática de um éster com atividade antioxidante (galato de isoamila) por esterificação de ácido gálico e álcool isoamílico em meio de solvente (terc-butanol). Oito lipases comerciais de diferentes fontes (microbianas e animal) foram empregadas na forma livre (extratos brutos) como biocatalisadores. As reações foram conduzidas empregando 0,25 mol L-1 de cada reagente (ácido gálico e álcool isoamílico), agitação mecânica de 240 rpm, 40°C, 4 h de reação e 1000 unidades de atividade enzimática baseada na hidrólise da emulsão de azeite de oliva. Os máximos valores de porcentagem de conversão foram obtidos para as preparações de lipase de Pseudomonas fluorescens – LPF (41,5 ± 5,1%) e de pâncreas suíno – LPP (38,4 ± 2,3%), a preparação de lipase testada com menor custo. A produtividade para estes sistemas de reação foi da ordem de 25 µmoles de ácido gálico consumido h-1 U-1. Estes revelam que a aplicação de uma lipase de baixo custo (LPP) pode ser promissora na produção de ésteres com propriedades antioxidantes, uma importante classe de compostos empregados na área de alimentos e cosméticos.

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“…PG, an ester formed by the condensation of gallic acid and propanol [ 16 ], is not a natural compound; it is produced via chemical synthesis. PG is used in the food, cosmetic, and pharmaceutical industries [ 17 ]. As a food additive, PG protects fats, oils, and fat-containing foods from rancidity.…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

Tanaka

Tsuneoka

2021

Biomolecules

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We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates AMP-activated protein kinase (AMPK) and increases reactive oxygen species (ROS) production to activate KDM2A. Esters of gallic acid, propyl gallate (PG) and epigallocatechin gallate (EGCG), and other chemicals, reduce cancer cell proliferation. However, whether these compounds activate KDM2A has yet to be tested. In this study, we found that PG and EGCG decreased rRNA transcription and cell proliferation through KDM2A in MCF-7 cells. The activation of both AMPK and ROS production by PG or EGCG was required to activate KDM2A. Of note, while the elevation of ROS production by PG or EGCG was limited in time, it was sufficient to activate KDM2A. Importantly, the inhibition of rRNA transcription and cell proliferation by gallic acid, PG, or EGCG was specifically observed in MCF-7 cells, whereas it was not observed in non-tumorigenic MCF10A cells. Altogether, these results suggest that the derivatization of gallic acid may be used to obtain new compounds with anti-cancer activity.

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Propyl Gallate

Cited by 10 publications

References 30 publications

Multi-tissue metabolomic profiling reveals potential mechanisms of cocoon yield in silkworms (Bombyx mori) fed formula feed versus mulberry leaves

Multi-tissue metabolomic profiling reveals potential mechanisms of cocoon yield in silkworms (Bombyx mori) fed formula feed versus mulberry leaves

Efeito Da Fonte De Lipase Na Produção De Um Éster De Ácido Gálico Por Esterificação Em Meio De Solvente

Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

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