Propranolol LA and ambulatory blood pressure.

Abstract

1 The technique of continuous recording of intra-arterial blood pressure in ambulant hypertensives has been used to investigate the effects of a long-acting formulation ofpropranolol (propranolol LA). 2 Seven subjects with untreated essential hypertension were studied before and 2 months after commencing treatment with propranolol LA once daily in the morning, results showing that smooth control of blood pressure and heart rate occurred throughout 24 h. 3 Bicycle ergometry tests performed by these subjects during both studies showed significant blood pressure reduction by propranolol LA during the mild and moderate grades of dynamic exercise. 4 In a parallel study where six treated hypertensives were monitored before and after substitution of standard propranolol by the 'LA' form, close correspondence of blood pressure throughout the 24 h occurred with each regimen.

Effects of long‐acting propranolol on blood pressure and heart rate in hypertensive Chinese.

“…The mean steady-state plasma drug concentrations in the 15 patients in Group A after 4 weeks' treatment with LA propranotol 160 and 320 mg, were similar to those reported in European patients of greater average body weight and height (Mann et al, 1980). We conclude, first, that there seem to be no important differences in the pharmacokinetics or the effects on BP and HR of LA propranolol, in the usual dosage, between hypertensive Chinese in this study and European subjects as reported elsewhere (Mann et al, 1980 …”

“…We conclude, first, that there seem to be no important differences in the pharmacokinetics or the effects on BP and HR of LA propranolol, in the usual dosage, between hypertensive Chinese in this study and European subjects as reported elsewhere (Mann et al, 1980 …”

“…A long-acting drug formulation should lower BP continually at rest and during exercise without important unwanted effects. Studies in European subjects have shown that once-daily dosing with conventional and LA formulations of propranolol controls mild hypertension (Mann et al, 1980). However, there are no comparable data on drug effects in Asian subjects, who are widely claimed to need smaller doses.…”

Control of blood pressure and reduction of echocardiographically assessed left ventricular mass with one‐daily timolol.

“…Compliance in the treatment of hypertension is one of the most important problems (Cohn, 1974) (Watson et al, 1979a;Mann et al, 1980). Timolol taken once daily lowered BP over the 24 h, although the reduction was not statistically significant for a short period between 04.00 h and 09.00 h when 2 points for SBP and 4 points for DBP were not significantly reduced.…”

Favourable effects of yohimbine on clomipramine‐induced orthostatic hypotension: a double‐blind study.

“…(1) the possibility of an antidepressant effect of yohimbine itself since a therapeutic role of noradrenergic function stimulation in the treatment of depression has been described (Puech, Lecrubier & Simon, 1979 Received December 31, 1980 EFFECT OF PROPRANOLOL LA ON AMBULATORY BLOOD PRESSURE We wish to comment on the conclusions drawn from the study of the effects of propranolol LA on ambulatory blood pressure recently reported by Mann et al (1980). Of the twelve previously untreated Group I patients, only seven were subsequently restudied; consequently, these represent a highly selected sub-group.…”