Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway

Sun, Bin; Dong, Chao; Lei, Hongzhao; Gong, Yubin; Li, Miaomiao; Zhang, Hongyu; Sun, Liang

doi:10.1016/j.cbi.2018.08.018

Cited by 24 publications

(22 citation statements)

References 34 publications

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“…Cell cycle analysis showed that population of the cells in G0/G1 was decreased in the groups treated with BPS. The distribution of S phase was increased by treatment with BPS (Sun et al, 2018). It indicated that BPS can trigger the proliferation of HA cells via inducing cell cycle transition.…”

Section: Bps Triggers the Proliferation And Cell Cycle Transition Of mentioning

confidence: 88%

Basic Fibroblast Growth Factor is Involved in Bisphenol S Induced Proliferation of Hemangioma Cells

Liu¹,

Hui²,

Wang³

et al. 2020

Preprint

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BackgroundThe hyperproliferation of mesoblastic vascular tissues can lead to the incidence of hemangioma (IHA), which is the most common benign tumor in infants. Estrogenic signals can trigger the progression of HA via activation of gene transcription.ResultsWe found that bisphenol S (BPS), one widely spread endocrine disrupting compound (EDC), can induce the proliferation of HA cells and trigger the G1 to S transition of cell cycle. Among the tested cytokines, BPS can up regulate of basic fibroblast growth factor (bFGF). Targeted inhibition of bFGF via its neutralization antibody can reverse BPS induced cell proliferation. Mechanistically, BPS can increase the mRNA expression of bFGF via increasing the transcription and mRNA stability. The activation of p65 and down regulation of miR-155-5p were responsible for BPS induced transcription and mRNA stability of bFGF, respectively. Conclusions: BPS can increase the expression of bFGF via activation of p65 and down regulation of miR-155-5p, which resulted in the proliferation of HA cells.

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Section: Bps Triggers the Proliferation And Cell Cycle Transition Of mentioning

confidence: 88%

Basic Fibroblast Growth Factor is Involved in Bisphenol S Induced Proliferation of Hemangioma Cells

Liu¹,

Hui²,

Wang³

et al. 2020

Preprint

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“…Moreover, propranolol can increase the constriction of hemangioma pericytes and further contracts the blood vessels (40). The role of propranolol in the medium term is major mainly inhibits cell proliferation and angiogenesis by blocking the relevant regulatory factors and signaling pathways of angiogenesis, including blocking the mitogen that activates the protein kinase pathway (Rac/MAPK) (41), blocking the PI3K signaling pathway (42), reducing hypoxia inducible factor 1 (43) and blocking DLL4/Notch1Akt signaling (44). At the same time, propranolol can decrease the synthesis and release of NO, inhibit vascular smooth muscle relaxation, and cause hemangioma vasoconstriction (45).…”

Section: Discussionmentioning

confidence: 99%

Propranolol vs. steroids in the treatment of infantile hemangiomas: A meta‑analysis

You

Xiao

et al. 2021

Mol Clin Oncol

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Infantile hemangioma (IH) is a common disease, and drug therapy is the most common treatment method. Clinically, steroids have long been used as first-line drugs, but in recent years, some doctors have begun to use propranolol to treat infantile hemangiomas (IHs). The present study performed a meta-analysis to evaluate the clinical effects of propranolol in comparison with steroids in the treatment of infantile hemangiomas. A detailed review of the literature on PubMed, Cochrane Library, Embase and Web of Science was performed prior to March 31, 2020. All literatures were compared with the clinical effects of propranolol and steroids in the treatment of infantile hemangiomas. A total of two researchers independently screened the literature according to the selection criteria, extracted data and assessed the risk of bias for the included studies. Review Manager 5.3 was used to meta-analyze all the included studies. According to the selection criteria, nine articles were included in the present study. The meta-analysis revealed that the effective rate of propranolol was greater than that of steroids in treating infantile hemangiomas [odds ratio (OR), 3.96, 95% confidence interval (CI), 2.47-6.37; P<0.00001]. Additionally, propranolol had fewer complications than steroids (OR, 0.21; 95% CI, 0.12-0.36; P<0.00001). The recurrence rate of the two groups was not statistically different (OR, 1.83; 95% CI, 0.59-5.70; P= 0.3) and the surgical resection rate of propranolol was lower than steroids (OR, 0.19; 95% CI, 0.08-0.46; P=0.0002). The present study demonstrated that propranolol is more effective than steroids for the treatment of IHs, and provides a theoretical basis for the clinical use of propranolol as an alternative to steroids.

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“…Even propranolol's efficacy in infantile hemangiomas was identified serendipitously in children who received the drug for the cardiac complications they developed due to their massive infantile hemangiomas (71). Despite its successful use, the mechanism and relationship of propranolol to vascular growth pathways remains to be elucidated (72)(73)(74).…”

Section: Discussionmentioning

confidence: 99%

A Primer on a Comprehensive Genetic Approach to Vascular Anomalies

et al. 2020

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The field of vascular anomalies has grown tremendously in the last few decades with the identification of key molecular pathways and genetic mutations that drive the formation and progression of vascular anomalies. Understanding these pathways is critical for the classification of vascular anomalies, patient care, and development of novel therapeutics. The goal of this review is to provide a basic understanding of the classification of vascular anomalies and knowledge of their underlying molecular pathways. Here we provide an organizational framework for phenotype/genotype correlation and subsequent development of a diagnostic and treatment roadmap. With the increasing importance of genetics in the diagnosis and treatment of vascular anomalies, we highlight the importance of clinical geneticists as part of a comprehensive multidisciplinary vascular anomalies team.

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Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway

Cited by 24 publications

References 34 publications

Basic Fibroblast Growth Factor is Involved in Bisphenol S Induced Proliferation of Hemangioma Cells

Basic Fibroblast Growth Factor is Involved in Bisphenol S Induced Proliferation of Hemangioma Cells

Propranolol vs. steroids in the treatment of infantile hemangiomas: A meta‑analysis

A Primer on a Comprehensive Genetic Approach to Vascular Anomalies

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