Propranolol: A migraine prophylactic since the 1960s

Souza, Wallyson Pablo de Oliveira; Fortes, Yasmine Maria Leódido; Soares, Adriana de Almeida; Silva‐Néto, Raimundo Pereira

doi:10.48208/headachemed.2023.2

Cited by 2 publications

(3 citation statements)

References 23 publications

(25 reference statements)

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“…With the discovery of the mechanism of migraine over time, drugs that can be used in its treatment have been approved by the FDA. Ergot alkaloids, 72 valproate, topiramate, 73 β-blockers, 74 calcium channel blockers, 75 and amitriptyline 76 are the most commonly used drugs in migraine treatment. 6.1.…”

Section: Migraine Drugs and Their Synthesismentioning

confidence: 99%

Migraine and Its Treatment from the Medicinal Chemistry Perspective

Pehlivanlar,

Carradori,

Simsek

2024

ACS Pharmacol. Transl. Sci.

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Migraine is a disease of neurovascular origin that affects the quality of life of more than one billion people and ranks sixth among the most common diseases in the world. Migraine is characterized by a moderate or severe recurrent and throbbing headache, accompanied by nausea, vomiting, and photo-phonophobia. It usually starts in adolescence and is twice as common in women as in men. It is classified as with or without aura and has chronic or acute treatment types according to the frequency of occurrence. In acute treatment, analgesics that relieve pain in the fastest way are preferred, while there are different options in chronic treatment. While non-specific methods were used in the treatment of migraine until the 1950s, triptans, ditans, and CGRP-receptor-dependent therapies (monoclonal antibodies and gepants) started to be used in the clinic more recently. In this Review, we focus on the synthesis, side effects, and pharmacological and pharmacokinetic properties of FDA-approved drugs used in acute and preventive-specific treatment of migraine.

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Section: Migraine Drugs and Their Synthesismentioning

confidence: 99%

Migraine and Its Treatment from the Medicinal Chemistry Perspective

Pehlivanlar,

Carradori,

Simsek

2024

ACS Pharmacol. Transl. Sci.

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“…21 The first beta-blocker to be used clinically was propranolol in 1964. 22 The mechanisms of action are related to its ability to act centrally on the serotonergic and noradrenergic neurotransmitter systems. The various beta-blockers differ in terms of selectivity for β1 and β2 receptors, their lipophilic capacity and blood-brain penetration.…”

Section: Beta-adrenergic Blockersmentioning

confidence: 99%

“…In addition, they interact with serotonergic 5-HT 2B and 5-HT 2C receptors, promoting their down regulation. 18,20,23 The most used beta-blockers with proven efficacy are propranolol (the oldest), 22 at doses from 30 to 180 mg/ day; metoprolol, at doses of 50 to 200 mg/day; atenolol, at doses of 50 to 120 mg/day; and nadolol, at doses from 80 to 240 mg/day (Table 2). Nadolol is the only one with predominantly renal excretion, without hepatic metabolism and more present in breast milk.…”

Section: Beta-adrenergic Blockersmentioning

confidence: 99%

Preventive and abortive treatment of migraine with traditional drugs. The state of the art

Silva-Néto,

Jevoux,

Krymchantowski

2023

Headache Med

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IntroductionMigraine is a chronic neurological disease, with a prevalence of 15.2% in Brazil. It is 2.2 times more prevalent in women, predominantly in the 18-50 age group. Its pathophysiological mechanism is still not completely understood. Possibly headache attacks and symptoms are associated with cortical spreading depression, the trigeminovascular system, neurogenic inflammation, vasodilation and genetic vulnerability.ObjectiveThis is a narrative review of preventive and abortive treatment of migraine.CommentMigraine treatment is based on three pillars: patient education, treatment of the disease itself or prevention of attacks, and acute treatment of headache attacks. The therapeutic classes of traditional drugs used in migraine prevention are beta-blockers, tricyclic antidepressants, calcium channel antagonists or blockers, and anticonvulsant neuromodulators. Specific drugs used in the treatment of headache attacks are triptans or serotonergic 5-HT1B/1D receptor agonists, ditans or 5-HT1F receptor agonists, and gepants or CGRP receptor antagonists.ConclusionTraditional drugs used in the preventive or abortive treatment of migraine are considered to be effective. Through modulation of the disease mechanisms, there is a reduction in the frequency, intensity and duration of headache attacks, and also in the disability caused by the headache. All this to improve the quality of life of patients. The therapeutic classes of traditional drugs used in migraine prevention are beta-blockers, tricyclic antidepressants, antagonists or blockers of calcium channels and anticonvulsant neuromodulators. Specific drugs used in the treatment of headache attacks are triptans or serotonergic 5-HT1B/1D receptor agonists,ditans or 5-HT1F receptor agonists, and gepants or CGRP receptor antagonists.

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Propranolol: A migraine prophylactic since the 1960s

Cited by 2 publications

References 23 publications

Migraine and Its Treatment from the Medicinal Chemistry Perspective

Migraine and Its Treatment from the Medicinal Chemistry Perspective

Preventive and abortive treatment of migraine with traditional drugs. The state of the art

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