“…Like all polymerases, the structure of the RdRp of flaviviruses resembles a right hand with the characteristic subdomain fingers (amino acids 273- 315, 416-496, and 543- 600), palm (amino acids 497-542 and 601-705), and thumb (amino acid 706-900) ( Zou et al, 2011 ; Najera, 2013 ; Galiano et al, 2016 ). In addition, the RdRp domain is unique to RNA viruses, and it is absent in human cells; for this reason, the DENV NS5 protein is an attractive target in the search for antiviral compounds ( Malet et al, 2008 ; De Burghgraeve et al, 2013 ; Meguellati et al, 2014 ; Alhossary et al, 2018 ; Mirza et al, 2019 ). The crystal structure of the RdRp catalytic domain of DENV was reported by Yap et al , allowing the exploration of regions in its structure that could be of interest for the design of anti-dengue compounds ( Yap et al, 2007 ).…”