Proposed Neuroimmune Roles of Dimethyl Fumarate, Bupropion, S-Adenosylmethionine, and Vitamin D3 in Affording a Chronically Ill Patient Sustained Relief from Inflammation and Major Depression

Abstract

We had discussed earlier that, after most of the primary author’s multiple sclerosis (MS) symptoms were lessened by prior neuroimmune therapies, use of dimethyl fumarate (DMF) gradually subdued his asthma and urticaria symptoms, as well as his MS-related intercostal cramping; and bupropion supplemented with S-adenosylmethionine (SAMe) and vitamin D3 (vit-D3) helped remit major depression (MD). Furthermore, the same cocktail (bupropion plus supplements), along with previously discussed routines (yoga, meditation, physical exercises, and timely use of medications for other illnesses), continued to subdue MD during new difficulties with craniopharyngioma, which caused bitemporal vision loss; sphenoid sinus infections, which caused cranial nerve-VI (CN6) palsy and diplopia; and through their treatments. Impressed by the benefit the four compounds provided, in this manuscript, we focus on explaining current neuroimmune literature proposals on how: (1) DMF impedes inflammation, oxidative stress, and cell death in CNS and peripheral tissues; (2) Bupropion curbs anxiety, MD, and enhances alertness, libido, and moods; (3) SAMe silences oxidative stress and depression by multiple mechanisms; and (4) Vit-D3 helps brain development and functioning and subdues inflammation. we realize that herein we have reviewed proposed mechanisms of remedies we discovered by literature searches and physician assisted auto-experimentation; and our methods might not work with other patients. We present our experiences so readers are heartened to reflect upon their own observations in peer-reviewed forums and make available a wide body of information for the chronically ill and their physicians to benefit from.

Revisiting bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3

“…Therefore, bupropion would better get administrated with antiinflammatory agents. In confirmation of our results, studies demonstrated that bupropion combination with anti-inflammatory agents yielded a better outcome 47,48 . Of note, bupropion is an antidepressant with complex mechanisms of action including the recently discovered effect on the serotonin receptors.…”

Revisiting Bupropion Anti-inflammatory Action: Involvement of the TLR2/TLR4 and JAK2/STAT3 

“…Therefore, bupropion would better get administrated with antiin ammatory agents. In con rmation of our results, studies demonstrated that bupropion combination with anti-in ammatory agents yielded a better outcome (Maciel et al, 2013, Sachinvala et al, 2020. Of note, bupropion is an antidepressant with complex mechanisms of action including the recently discovered effect on the serotonin receptors.…”

Differential Effects of 1α,25-Dihydroxyvitamin D3 on the Expressions and Functions of Hepatic CYP and UGT Enzymes and Its Pharmacokinetic Consequences In Vivo

“…This observation may occur due to markedly lower HBUP renal excretion (CL R ) in 1,25(OH) 2 D 3 -treated rats and/or the involvement of other enzymes such as Cyp2c and Cyp3a in BUP metabolism [ 39 ], which requires further investigation. Since bupropion supplemented with vitamin D 3 can be clinically used to help to lessen major depression [ 40 ] and VDR ligand drugs have been developed with various therapeutic indications [ 8 ], the further study is required regarding clinical relevance of this pharmacokinetic change in rats. However, in the case of TOL, the AUC, CL, and CL NR of TOL, and the AUC of HTOL remained unchanged in vivo.…”