Proposed Mode of Action of Corticosteroids on the Connective Tissue

Houck, J. C.; Patel, Y. M.

doi:10.1038/206158a0

Cited by 71 publications

(16 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, conflicting results about the influence of glucocorticoids on the collagen metabolism have been reported (1,2,3). Our results indicate that the reported effects may at least in part be due to the way in which the animals are housed.…”

Section: Introductioncontrasting

confidence: 74%

The Effect of Different Kinds of Animal Housing on Parameters of Collagen Metabolism in Guinea Pigs

Wepler¹,

Burkhardt²,

Burkhardt³

et al. 1977

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Wepler et al.: Effect of different kinds of animal housing on parameters of collagen metabolism 653 Summary: Parameters of collagen metabolism were investigated in guinea pigs, both untreated and treated with glucocorticoids. One series consisted of animals housed under normal conditions, the others of SPF animals from the same strain. There are marked differences in certain parameters, including the hydroxyproline content and the reaction of the collagen to glucocorticoids.

show abstract

Section: Introductioncontrasting

confidence: 74%

The Effect of Different Kinds of Animal Housing on Parameters of Collagen Metabolism in Guinea Pigs

Wepler¹,

Burkhardt²,

Burkhardt³

et al. 1977

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…Corticosteroids are the most important and they act at 3 levels: they have an antimitotic effect on fibroblasts [57], an antisynthetic effect on fibroblasts when topically applied [58] and they stimulate collagenase. Corticosteroid medications are known to weaken collagen structures by causing necrosis of the fibrils and disorganization of the collagen arrangement [59,60]; however, its significance is still controversial [18,61,62]. 4) Genetic and constitutional factors are mostly unknown.…”

Section: Discussionmentioning

confidence: 99%

Bilateral spontaneous concurrent rupture of the patellar tendon in a healthy man: case report and review of the literature

2010

View full text Add to dashboard Cite

Knee extensor mechanism disruption is a serious injury usually requiring emergent treatment. Rupture of the patellar tendon is rare in the normal population; bilateral spontaneous concurrent rupture in a healthy population is an exceptional event. We describe the case of a 39-year-old man with bilateral spontaneous concurrent rupture of the patellar tendon without any underlying systemic disease or drug use.

show abstract

“…These data are consistent with the observed involutional changes in articular cartilage ultrastructure in c o r t i c o s t e r o i d -t r e a t e d o r s t a r v e d a n imals (26, 27), and also with observations of several investigators on changes in polysaccharide metabolism a n d skin content and epiphyseal and embryonic cartilage (6, 28, 7-9, 11-14, 5, 16, 18). They generally conform, as well, to theoretic and experimental observations on the action of corticosteroids on connective tissues (29,10,(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

The effect of systemic corticosteroids on rabbit articular cartilage

Mankin¹,

Zarins²,

Jaffe³

1972

Arthritis & Rheumatism

View full text Add to dashboard Cite

Rabbits were treated for up to 9 weeks with daily doses of cortisone. Cartilage from the distal femur was studied biochemically at regular intervals, and no change in the content of DNA but a significant and progressive decline in the concentration of hexosamine were noted. In vitro incorporation of J5S04 and W-glycine was depressed markedly. Because the test animals lost 25% of their body weight, a separate group of starved controls were studied and the changes noted were similar to those seen with corticoid treatment but were not as marked.Prior studies from this and other laboratories demonstrated the potential deleterious effects of intraarticularly administered corticosteroids on articular cartilage of experimental animals. It has been shown that, when injected into the animal joint, both soluble and slightly soluble steroid products used in clinical treatment may significantly inhibit protein and polysaccharide synthesis by the chondrocyte, and that prolonged treatment may produce specific pathologic lesions (1 -5). Submitted for publication April 19, 1972; accepted July 13, 1972. Numerous reports have indicated that systemically administered corticosteroids may alter cell metabolism and, specifically, can cause inhibition of protein and polysaccharide synthesis in a number of organs (5-19). Little is known, however, regarding the effect of the hormone(s) on articular cartilage; but, from the data reported for other tissues, as well as theoretic considerations, it would seem likely that systemically administered steroids would significantly interfere with the anabolic activities of the cartilage cell.The purpose of this report is to describe the results of an experimental study in which cortisone acetate, 4.5 mg/kg/day, was administered intramuscularly to adult rabbits. T h e articular cartilage from the distal femur was analyzed for alterations in biochemical constituents and rates of synthesis of the matrix at intervals up to 9 weeks. Early analyses of the data demonstrated a significant effect on the general metabolic state of the rabbit, as indicated by a weight loss of up to 28.8%. These findings dictated a second metabolic experiment, in which another group of rabbits was partially starved over a 7-week period. T h e articular cartilage from both groups of animals was studied biochemically and metabolically, and the data showed a significant depletion in polysaccharide content and a decrease in rates of synthesis of both protein and polysaccharide of the matrix, more severe in the steroid-treated group than in the starved controls. T h e changes were proportional to the duration of the study and the severity of the systemic catabolic state, as measured by weight loss. O n the basis of these observations, it is possible to speculate on the effect of systemically administered corticosteroids on rabbit articular cartilage and the relationship of this response to starvation and negative nutritional balance. MATERIALS AND METHODSAdult New Zealand white (NZW) rabbits were obtained Study 1Forty N Z W r...

show abstract

Proposed Mode of Action of Corticosteroids on the Connective Tissue

Cited by 71 publications

References 13 publications

The Effect of Different Kinds of Animal Housing on Parameters of Collagen Metabolism in Guinea Pigs

The Effect of Different Kinds of Animal Housing on Parameters of Collagen Metabolism in Guinea Pigs

Bilateral spontaneous concurrent rupture of the patellar tendon in a healthy man: case report and review of the literature

The effect of systemic corticosteroids on rabbit articular cartilage

Contact Info

Product

Resources

About