Proposed Formulae for Determining Blood Transfusion Requirements in Children with Severe Anaemia

Adedoyin, OT; Afolabi, JK; Oyeyemi, Bashir O.

doi:10.4314/njp.v31i1.12084

Cited by 4 publications

(11 citation statements)

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“…[18,19] The present study also revealed a higher transfusion rate of blood and blood products among subjects older than five years of age compared with their counterparts below five years of age. The findings disagreed with those of previous authors [17,20] The apparent reason may be a result of a higher concentration of disorders of haemoglobin synthesis such as sickle cell disorder and malignancies which occur commonly among older children. [21] The mean pre-transfusion PCV value of 15.2% observed in the present study was higher than 14.6% previously reported by Adedoyin et al [20] in Ilorin.…”

Section: Annals Of Health Research Volume 6 Issue No 1 2020_______contrasting

confidence: 99%

Indications for blood and blood products transfusions among children in a semi-urban tertiary hospital in Nigeria

Akodu¹,

Adekanmbi²,

Gbadebo³

et al. 2020

Ann Health Res

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Background: Anaemia is prevalent among children in our environment, often necessitating blood transfusions. The knowledge of the common indications for blood transfusion and the required preventive measures is likely to reduce the transfusion rates. Objective: To determine the disease conditions requiring blood transfusion in post-neonatal age children at the Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. Methods: The hospital records of all children aged 1 month to 18 years admitted into the post-neonatal ward who received blood transfusions over 18 months (1st July 2015to31st December 2016) were reviewed. Results: There were 710 paediatric admissions out of which 82 (11.6%) received blood transfusions. Ninety transfusions were carried out amongst 82 children, at a ratio of 1.1 transfusions per child. Severe malaria (28.1%), sickle cell anaemia (19.5%) and septicaemia (18.3) were the most common disease conditions requiring blood transfusions. The leading blood products transfused included packed red cells (64.5%) and whole blood (30.0%). Conclusion: Blood transfusion is frequently indicated in the paediatric population in our setting, largely due to severe malaria and sickle cell anaemia problems. Intensifying efforts on the use of long-lasting insecticide-treated nets and environmental control may reduce the prevalence of severe malaria, while improved nutrition, adequate hydration, regular malaria prophylaxis, prompt treatment of infections and regular use of haematinics may minimize the need for blood transfusions among children with sickle cell anaemia.

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Section: Annals Of Health Research Volume 6 Issue No 1 2020_______contrasting

confidence: 99%

Indications for blood and blood products transfusions among children in a semi-urban tertiary hospital in Nigeria

Akodu¹,

Adekanmbi²,

Gbadebo³

et al. 2020

Ann Health Res

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“…[27] The reduction in the parameters except O 2 sat and blood pressure in response to blood transfusion in this study is consistent with previous reports in adult and children. [11,12,28,29] The HR and RR had the most easily measurable reduction compared with change in liver size. This easily measured difference in HR has been reported in previous works.…”

Section: Discussionmentioning

confidence: 96%

“…[9,10] This has also led to the search for a safe transfusion regimen in non-isovolumetric transfusion with respect to rate of transfusion. [11,12] However, in a study involving adult patients with severe anemia, no untoward cardiovascular effects were reported following 800 mL of packed cells transfused at 18 mL/min. [13] In severe anemia, both hemodynamic and non-hemodynamic mechanisms are activated to compensate for the declining oxygen carrying capacity.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular responses to blood transfusion in children with anemic heart failure

Sadoh

Okposio

2012

Niger J Clin Pract

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“…Although Elzik et al [ 8 ] demonstrated that PCV at 15 minutes and 6 hours after red cell transfusion in stable neonates were similar and both were significantly different from pretransfusion PCV, it is difficult from their study design to conclude that haematocrit equilibration process had been completed at 6 hours since they did not check PCV levels beyond 6 hours. Similarly, Adedoyin et al [ 4 ] reported that 1-hour and 7-hour posttransfusion haemoglobin differed only by 0.2 g/dL but there were no estimated PCV levels after 7 hours. Further changes in PCV could have occurred beyond 7 hours after transfusion.…”

Section: Discussionmentioning

confidence: 97%

“…The volume of packed cells to be transfused was calculated as V (mL) = 3 × wt (kg) × (expected change in haemoglobin.) [ 4 ]. This volume was given as a continuous infusion using an infusion pump or given in aliquots over a period of 3-4 hours [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria

Audu

Otuneye

Mairami

et al. 2015

International Journal of Pediatrics

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Anaemia is a common morbidity in the NICU and often requires transfusion of packed red blood cells. Haematocrit equilibration following red cell transfusion occurs over time ultimately resulting in a stable packed cell volume (PCV). Knowledge of this equilibration process is pertinent in the accurate timing of posttransfusion (PT) PCV. We conducted a prospective study to determine an appropriate timing for PT PCV estimation on 47 stable anaemic babies at the Neonatal Unit of National Hospital, Abuja. Values of PCV were determined before transfusion and at 1, 6, 12, 24, and 48 hours posttransfusion. Forty of the recruited neonates and young infants were analyzed. Their gestational age range was 26 to 40 weeks. 1-hour PT PCV (48.5% ± 5.5%) was similar to the 6-hour PT PCV (47.8% ± 5.6%) P = 0.516, but both were significantly different from the 12-hour (46.8% ± 5.9%), 24-hour (45.9 ± 5.8%), and 48-hour (45.4% ± 6.2%) PT PCVs. The 12-hour PT PCV was similar to the 24-hour and 48-hour PT PCVs (P = 0.237 and 0.063, resp.). We concluded that, in stable nonhaemorrhaging and nonhaemolysing young infants, the estimated timing of haematocrit equilibration and, consequently, posttransfusion PCV is 12 hours after red blood cell transfusion.

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Proposed Formulae for Determining Blood Transfusion Requirements in Children with Severe Anaemia

Cited by 4 publications

References 0 publications

Indications for blood and blood products transfusions among children in a semi-urban tertiary hospital in Nigeria

Indications for blood and blood products transfusions among children in a semi-urban tertiary hospital in Nigeria

Cardiovascular responses to blood transfusion in children with anemic heart failure

Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria

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