Introduction: Obesity has become a major health problem worldwide due to high comorbidity and an increasing prevalence. It is the greatest risk factor for obstructive sleep apnea (OSA). Owing to lack of data on the association of obesity and OSA within the country, the present study was designed to evaluate the pattern of sleep disordered breathing (SDB) among obese Indian subjects.
Material and Method:The study was prospectively carried out in Sleep Laboratory of LRS Institute of Tuberculosis and Respiratory Diseases, New Delhi. 30 obese [having body mass index BMI > 27.5 kg/m 2 ] and 10 non-obese (having BMI < 27.5 kg/m 2 ) subjects were consecutively enrolled into the study (obesity) and the control (non-obese) groups respectively as per the World Health Organization (WHO) Criteria of Obesity for Asians. Detailed clinical history including that of sleep was taken, a physical examination along with anthropometric measurements like neck circumference (NC), waist circumference (WC) and hip circumference (HC) was done and laboratory investigations were performed in all subjects, who thereafter, underwent an overnight polysomnography (PSG) on Compumedics E-Series sleep software. Sleep was staged as per Rechtshaffen and Kales (R & K) rules and SDB evaluated as per standard criteria. Data was subjected to statistical analysis. Results: There were 16 obese, 8 severely obese & 6 morbidly obese subjects. Respective characteristics of the obesity and the control group subjects showed a mean age of 47.73 and 40.90 years, a male-female ratio of 19: 11 and 7:3, and a mean BMI of 33.46 and 23.73 kg/m 2 . Mean Apnoea-Hypopnoea Index (AHI) was significantly higher among the subjects of the obesity group as compared to the controls. Similarly, mean AHI was significantly higher among the obese males, those having NC between 35 to < 45 cms, symptomatics, those having 4 to 6 number of symptoms, and those having co-morbidities as compared to the respective non-obese counterparts. Mean value of sleep latency was higher, while that of Total Sleep Time (TST) & sleep efficiency lower in the obesity than the control group. Oxygen De-saturation Index (ODI) and indices of arousal, Periodic Limb Movement (PLM) in Sleep (PLMS) & PLM with arousals were significantly higher in the obesity as compared to the control group respectively. No significant differences were noticed between the groups with regard to sleep stage percentages.