Proposal: Trauma as the Cause of the Peyronie's Lesion

Devine, Charles J.; Somers, Kenneth D.; Jordan, Gerald H.; Schlossberg, Steven M.

doi:10.1016/s0022-5347(01)65361-8

Cited by 343 publications

(208 citation statements)

References 15 publications

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“…The consequent erectile deformity frequently results in the inability of the male to participate in satisfactory coitus. 5,8 Peyronie's disease is not a rare clinical entity, with incidence rates of up to 3%. [2][3][4][5] Familial occurrence has been cited and pedigree analysis has suggested an autosomal dominant mode of inheritance.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous theories regarding the etiology of Peyronie's have been proposed, including trauma, failure of fibrin degradation and autoimmune factors. 5,[7][8][9][10][11] However, no single theory has been able to explain adequately the precise events through which patients develop Peyronie's disease. Data from the study of similar fibrotic diseases such as Dupuytren's contracture and others have raised questions about the role of cytogenetic alterations in the development of fibrosis.…”

Section: Introductionmentioning

confidence: 99%

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Chromosomal instability is demonstrated by fibroblasts derived from the tunica of men with Peyronie's disease

Nicholson

Pierpaoli

et al. 2004

Int J Impot Res

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Peyronie's disease is a fibrotic disorder, a condition characterized by cellular proliferation and excess extracellular matrix production. Previous work in related conditions has demonstrated chromosomal instability. This investigation was undertaken to analyze fibroblasts derived from Peyronie's disease tunical tissue for abnormalities of chromosome number and progression of cytogenetic aberrations during cell culture. Tunical tissue was excised from men with Peyronie's disease from both plaque and nonplaque tissue and cells were explanted in culture. Control cells were derived from both neonatal foreskins and normal tunica from men with congenital penile curvature. Fluorescent in situ hybridization was used to probe for chromosomes 7, 8, 17, 18, X and Y. Control cells demonstrated normal copy number for all chromosomes analyzed. In contrast, Peyronie's disease plaque-derived fibroblasts demonstrated frequent aneusomies in chromosomes 7, 8, 17, 18 and X and recurrent deletions of chromosome Y. Peyronie's disease nonplaque tunicaderived fibroblasts demonstrated infrequent chromosomal changes early in culture; however, with repeated passaging the majority of cell cultures demonstrated aneusomies in at least one chromosome. These data indicate that Peyronie's disease plaque-derived fibroblasts have consistent aneusomies even at early passage and that nonplaque tunica-derived cells from men with Peyronie's disease also demonstrate chromosomal instability. This suggests that the tunica albuginea of men with Peyronie's disease may be predisposed to undergoing unregulated fibrosis. These findings confirm the transformed nature of the Peyronie's disease tunical fibroblasts studied in this analysis. While the etiology of these findings is not clear, it is likely that these pathobiological characteristics contribute to the pathophysiology of this disease process.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chromosomal instability is demonstrated by fibroblasts derived from the tunica of men with Peyronie's disease

Nicholson

Pierpaoli

et al. 2004

Int J Impot Res

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“…22 The longitudinal layer is also thinnest at the 3 and 9 o'clock positions; consistent with the greatest number of traumatic penile fractures in those positions. 5,6,23 Patients with Peyronie's disease most often show plaque formation on the dorsal side of the penis. 1 -8,23 There are at least two possible explanations for this observation.…”

Section: The Microscopic Anatomy Of the Tunica Albuginea And Its Impamentioning

confidence: 99%

Pathophysiology of Peyronie's disease

Moreland

Nehra

2002

Int J Impot Res

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“…during sexual activity) can result in delamination of the tunica albuginea and microvascular damage (8,15). Fibrin was found to be potentially involved in the development of the fibrotic plaque in a murine model of PD (16).…”

Section: Discussionmentioning

confidence: 99%

Animal experimental model of Peyronie’s disease: A pilot study

Cerruto¹,

D’Elia

Molinari³

et al. 2013

Arch Ital Urol Androl

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The Peyronie's disease (PD) is an idiopathic disorder of connective tissue of the penis, that involves the tunica albuginea of the corpora cavernosa and the adjacent areolar space. A fibrous plaque replaces the elastic fibers that normally constitute the tunica albuginea, limiting its extensibility, and causing pain during erection, erectile dysfunction and difficulty of penetration, as a result of the deviation of the penis. Although it was once considered a relatively infrequent disease, some studies show that the prevalence of IPP is Results: The MRI acquisitions, both in coronal and axial projection, showed an adequate visibility of the anatomical structures. At 7 days after thrombin injection with the dartos incision it was evident an oedematous portion, visible as a hyperintense area, located at the injection area. At 21 days after injection, oedema was partially resolved: the injection part of the hyperintense area remains unchanged, while the remaining area appears to be part of a re-absorption and re-organization process. Conclusions: Since none of the various treatment modalities currently available for the management of PD is able to bring healing, the researchers' attention is increasingly directed towards innovative treatment programs, such as the use of stem cells of mesenchymal origin. At the present time, the research in PD is hampered by the lack of universally accepted animal model and this is likely attributed to the limited insight into PD mechanisms and the difficulties faced by current animal models to truly represent the complexity.

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Proposal: Trauma as the Cause of the Peyronie's Lesion

Cited by 343 publications

References 15 publications

Chromosomal instability is demonstrated by fibroblasts derived from the tunica of men with Peyronie's disease

Chromosomal instability is demonstrated by fibroblasts derived from the tunica of men with Peyronie's disease

Pathophysiology of Peyronie's disease

Animal experimental model of Peyronie’s disease: A pilot study

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