Proposal of a simple and rapid method for the chemotherapy preparations analytical control by spectrophotometry UV-Vis method

Abstract

Introduction The preparation of anticancer chemotherapy in a hospital must meet several objectives; the first main is the quality, which can be provided by setting up a surveillance system and a quality control of each preparations. The aim of this work is to present a simple, fast and accurate spectrophotometric method for the routine control of cytotoxic preparations. Materials and methods This is a study carried out in the cytotoxic preparation unit of the university center of Rabat-Sale children’s hospital in Morocco. All samples of preparations were collected and analyzed daily on the site. After validation of the analytical method with respect to many parameters such as: linearity, accuracy and precision according to ICH Q2 guidelines, samples of cytotoxic preparations collected were assayed. Results The results are satisfactory with good level of exactitude, and high precision. Conclusion Compared to other techniques, this method can be considered as a useful alternative in the routine quality control of preparations. It can quickly obtain qualitative and quantitative information with instrumentation and inexpensive reagents.

Thermo-Responsive Sol-Gel-Based Nano-Carriers Containing Terbinafine HCl: Formulation, In Vitro and Ex Vivo Characterization, and Antifungal Activity

“…Particle size is a crucial parameter that is of very high importance while formulating a nanoemulsion. Initially, the formulation was thinned out, and the particle size was evaluated using the Dynamic Light Scattering (DLS) technique at a temperature of 25 • C [25]. Figure 8 demonstrates that the particle size of the optimized formulation was 272.2 nm.…”

Selective fluorescence turn-on detection of combination cisplatin–etoposide chemotherapy based on N-CDs/GSH-CuNCs nanoprobe

“…Dose adjustments may be required to mitigate harm from interactions between these rstline chemotherapeutics. The studied drugs were previously analyzed utilizing various analytical techniques, including HPLC (High-Performance Liquid Chromatography), [21][22][23][24][25] spectrophotometric, 26,27 spectrouorometric, [28][29][30][31][32][33][34] and electrochemical methods. [35][36][37][38][39] Fluorescent metal nanoclusters are emerging as a new class of nanoscale uorophores.…”

Chemometric Analysis of UV-Visible Spectral Fingerprints for the Discrimination and Quantification of Clinical Anthracycline Drug Preparation Used in Oncology

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