Proposal of a protocol for the photodynamic therapy of malignant brain tumours

Perria, C; Casu, G.; Sgaramella, E.

doi:10.1016/1011-1344(90)85117-f

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…In the 1990s, the PDT with PHOTOFRIN ® (porfimer sodium) was evaluated at low or moderate light intensity, and in some cases, intraoperative adjuvant therapy was applied [ 68 , 69 ]. The above clinical trial was conducted on newly diagnosed GBM patients and recurrent GBM patients, and the results were significant.…”

Section: Advantages and Clinical Application Of Pdt For The Treatment Of Brain Tumorsmentioning

confidence: 99%

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

Kim

Lee

2022

Biomedicines

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The current treatment for malignant brain tumors includes surgical resection, radiotherapy, and chemotherapy. Nevertheless, the survival rate for patients with glioblastoma multiforme (GBM) with a high grade of malignancy is less than one year. From a clinical point of view, effective treatment of GBM is limited by several challenges. First, the anatomical complexity of the brain influences the extent of resection because a fine balance must be struck between maximal removal of malignant tissue and minimal surgical risk. Second, the central nervous system has a distinct microenvironment that is protected by the blood–brain barrier, restricting systemically delivered drugs from accessing the brain. Additionally, GBM is characterized by high intra-tumor and inter-tumor heterogeneity at cellular and histological levels. This peculiarity of GBM-constituent tissues induces different responses to therapeutic agents, leading to failure of targeted therapies. Unlike surgical resection and radiotherapy, photodynamic therapy (PDT) can treat micro-invasive areas while protecting sensitive brain regions. PDT involves photoactivation of photosensitizers (PSs) that are selectively incorporated into tumor cells. Photo-irradiation activates the PS by transfer of energy, resulting in production of reactive oxygen species to induce cell death. Clinical outcomes of PDT-treated GBM can be advanced in terms of nanomedicine. This review discusses clinical PDT applications of nanomedicine for the treatment of GBM.

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Section: Advantages and Clinical Application Of Pdt For The Treatment Of Brain Tumorsmentioning

confidence: 99%

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

Kim

Lee

2022

Biomedicines

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“…More recently, Perria and coworkers (1988) have treated additional patients, and have examined the role of the type of sensitizer, the method of illumination used and the peculiarities of glial tumors on the outcome of therapy; they have proposed a standard protocol to be used for the PDT of malignant brain tumors (Perria et al, 1990). Kostron et al (1987,1990) compared the effects of using different routes of injection of the sensitizer (Photofrin 11) into the patient (intravenously, into the internal carotid artery, and directly into the tumor mass) on the PDT of brain tumors; all three routes appear to be feasible.…”

Section: Clinical Applications Of Dye-sensitized Photoreactions In Nementioning

confidence: 99%