Proposal for a new mechanism of action for aluminum phosphide (ALP) for causing local injuries in ALP poisoning

Mirakbari, Seyed Mostafa

doi:10.1177/0960327115619221

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…It has been shown that thermal injuries contribute to high mortality rate in ALP poisoning cases. [ 1 2 ] These findings have appeared in literature and have been employed in practice. [ 3 4 5 ] Yet, subsequent literature reviews and subordinate deductive reasoning indicate constant ignoring of these findings.…”

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confidence: 73%

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The convergence of considerations in aluminum phosphide poisoning: The occurrence of injuries beyond the metabolic manifestations

Mirakbari

2017

J Res Med Sci

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confidence: 73%

“…[ 1 ] These findings have resulted in elucidating new mechanisms of action of ALP and demonstrating ALP poisoning management modifications. [ 2 ]…”

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confidence: 99%

The convergence of considerations in aluminum phosphide poisoning: The occurrence of injuries beyond the metabolic manifestations

Mirakbari

2017

J Res Med Sci

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“…23 BMSCs are non-haematopoietic cells and do not express CD45. 24 In this study, the expressions of CD44, CD90.1 and Sca-1, is an osteogenesis-specific transcription factor that plays a vital role in the development, differentiation and bone formation of osteoblasts, and its expression can be regulated by a variety of miRNAs 26,27 ; ALP is a marker for early cell differentiation and is related to bone cell synthesis before bone calcification, 28 The cells were cultured in OS for 3 days, and the expressions of osteogenic differentiationrelated genes were detected by qRT-PCR. (C) Calcium deposition was determined by Alizarin Red S staining after the cells were treated with miR-140-5p mimic and OS.…”

Section: Discussionmentioning

confidence: 95%

“…Therefore, C3H10T1/2 cells were used as the research objects to explore the effect of miR‐140‐5p on osteogenic differentiation. Runx2 is an osteogenesis‐specific transcription factor that plays a vital role in the development, differentiation and bone formation of osteoblasts, and its expression can be regulated by a variety of miRNAs 26,27 ; ALP is a marker for early cell differentiation and is related to bone cell synthesis before bone calcification, 28 and overexpressed miR‐615‐3p can inhibit ALP expression 29 ; Spp1 is a late marker for osteoblasts and is closely related to bone matrix mineralisation; Bglap is a signature enzyme of osteoblasts. Studies found that the differential expressions of miR‐29b, miR‐30c2 and miR‐125b are closely related to Spp1 and Bglap 30 .…”

Section: Discussionmentioning

confidence: 99%

MiR‐140‐5p promotes osteogenic differentiation of mouse embryonic bone marrow mesenchymal stem cells and post‐fracture healing of mice

Jiao

Feng

et al. 2020

Cell Biochemistry & Function

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MiR-140-5p is high expressed in normal fracture healing, but its specific role and mechanism in tissue-to-bone healing are rarely reported. Therefore, this study investigated the effects of miR-140-5p on tissue-to-bone healing. Clone formation experiment, flow cytometry, Alizarin Red S Staining and Oil Red O Staining were performed to investigate the biological characteristics of mouse embryonic bone marrow mesenchymal stem cells C3H10T1/2. MiR-140-5p mimic was transfected into osteogenic medium (OS)-treated C3H10T1/2 cells to investigate the effects of miR-140-5p on osteogenic differentiation. MiR-140-5p transgenic mouse model and the transgenic fracture model were established, and the effects of miR-140-5p on osteogenic differentiation, bone mineral density (BMD) and bone mass of bone tissues were detected by haematoxylin and eosin staining and computed tomography scan. The expressions of osteocalcin, differentiation-related genes (Runx2, ALP, Spp1 and Bglap3) and miR-140-5p were determined by quantitative realtime polymerase chain reaction. C3H10T1/2 cells showed the abilities of forming cloned differentiation of osteogenesis, fat cells, and its phenotypes including CD44, CD90.1 and Sca-1 but excluding CD45 haematopoietic stem cell marker. Overexpression of miR-140-5p promoted the expressions of differentiation-related genes and calcium deposition of OS-treated C3H10T1/2 cells. MiR-140-5p increased the expression of osteocalcin, BMD and bone mass and promoted bone healing of miR-140-5p-transgenic mice with fracture. MiR-140-5p promoted osteogenic differentiation of mouse embryonic bone marrow mesenchymal stem cells and post-fracture healing in mice. Significance of the study C3H10T1/2 cells showed the abilities of forming cloned differentiation of osteogenesis, fat cells and its phenotypes including CD44, CD90.1 and Sca-1 but excluding CD45 haematopoietic stem cell marker. Overexpression of miR-140-5p promoted the expressions of differentiation-related genes and calcium deposition of osteogenic medium-treated C3H10T1/2 cells. MiR-140-5p increased the expression of osteocalcin and bone mineral density and bone mass and promoted bone healing of miR-140-5p-transgenic mice with

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“…In case of contact with moisture, the phosphine gas is released. Once it is swallowed, these metal phosphide compounds are combined with hydrochloric acid (HCl) in stomach and creates toxic phosphine gas (AlP + 3 H+ → Al 3+ + PH 3 ) [1,2]. The released phosphine mixes into the blood through stomach and bowels, and is then transported to the liver.…”

Section: Introductionmentioning

confidence: 99%

A race against time in lethal aluminum phosphide intoxication: a case report

Altıntop¹,

Kaynak²

2016

Med-Science

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Aluminum phosphide (AP) is a condition that results in death in case of use for suicide purpose. The phosphine gas, which is released as a result of aluminum phosphide intake, has high level of toxicity. It leads to cellular level hypoxia and inhibition of oxidative phosphorylation. Aluminum phosphide intoxication may cause metabolic acidosis, arrhythmia, acute respiratory distress syndrome, and shock. High-dose intakes may lead to death within hours. 22 year-old female patient was taken to our emergency service because of the suicide attempt with 6000mg aluminum phosphide tablet. We aimed to share our experience with our aluminum phosphide intoxication, which has no known antidote and leads to rapid death in follow-up. We aim to present our experiences with our case of intoxication from aluminum phosphide, which causes high mortality after the intake. 22 year-old female patient was transferred to our hospital due to suicide attempt with 6000mg aluminum phosphide tablet. The patients have no known comorbidities, medicine use or allergic history. We believe that, in preventing the high mortality rate in aluminum phosphide intoxication, metabolic acidosis, arrhythmia, ARDS and measures against the shock and the hemodialysis in early period should be performed. Although its efficiency has not been clearly proved and its use has not entered into algorithms, the use of MgSO4 and N-Acetyl-Cysteine in supportive care is an option for such cases. Further studies and proven treatment methods are needed in AP toxicity.

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Proposal for a new mechanism of action for aluminum phosphide (ALP) for causing local injuries in ALP poisoning

Cited by 4 publications

References 6 publications

The convergence of considerations in aluminum phosphide poisoning: The occurrence of injuries beyond the metabolic manifestations

The convergence of considerations in aluminum phosphide poisoning: The occurrence of injuries beyond the metabolic manifestations

MiR‐140‐5p promotes osteogenic differentiation of mouse embryonic bone marrow mesenchymal stem cells and post‐fracture healing of mice

A race against time in lethal aluminum phosphide intoxication: a case report

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