Proportionate Cardiovascular Mortality in Chronic Inflammatory Disease in Adults in the United States From 1999 to 2019

Abstract

Background: Despite a rising prevalence of chronic inflammatory disease (CID), the recent trends in cardiovascular disease (CVD) mortality of patients with CID is scarce. In this study, we investigated patterns of CVD mortality in systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) compared with the general population.Methods: We used the 1999 to 2019 multiple causes of death files from the national center for health statistics to analyze patterns and trends of proportionate CVD mortality in CID compared with the general population. Results:We analyzed a total of 11,154 CVD deaths in IBD, 58,337 CVD deaths in RA, 6227 CVD deaths in SLE, and 17,826,871 CVD deaths in the general population. Between 1999 and 2019, we found that proportionate CVD mortality decreased significantly in the IBD group (25% to 16%), RA group (34% to 25%), and the general population (41% to 31%), but did not change for the SLE group (15% to 15%). Patients with SLE who died of CVD were approximately 10 years younger compared with CVD decedents with RA, IBD, or general population. The White population had higher proportionate CVD mortality than African American (IBD [19% vs 16%-18%] and SLE [14%-16% vs 12-14%], respectively).Conclusions: This study identifies current trends in CVD mortality in the CID population and elucidates current demographics in CVD mortality in CID. Although proportionate CVD mortality decreased in the general population, and in patients with RA and IBD, there was no change among patients with SLE. Further studies are needed to elucidate these differences.

Impact of cigarette smoking on rheumatoid arthritis-associated lung diseases: a retrospective case control study on clinical and radiological features and prognosis

“…RA-related extra-articular manifestations and comorbidities are associated with exacerbated outcomes of the patients. Studies have demonstrated that respiratory diseases, cardiovascular diseases and neoplasms are the primary causes of death in RA patients [ 32 – 34 ]. The 1-year, 5-year and 10-year mortality of RA-associated ILD was 13.9%, 39.0% and 60.1% in a population-based cohort study [ 35 ].…”

Proportionate and Absolute Vascular Disease Mortality by Race and Sex in the United States From 1999 to 2019

“…Herein, we sought to identify the pattern of PVD mortality that has evolved over the past 2 decades. For this, we used the Centers for Disease Control and Prevention’s Wide‐Ranging Online Data for Epidemiologic Research database 10 , 11 to identify the change in PVD mortality from 1999 to 2019 by racial background.…”

Cardiogenic shock complicating myocardial infarction: mortality trends in the United States from the past two decades

“…This retrospective cohort study was conducted using the Center for Disease Control (CDC) and Prevention Wideranging Online Data for Epidemiologic Research -Multiple Cause of Death Registry, a publicly available national registry comprising mortality data in the United States. 2,3 We selected all deaths (age 35 years) with multiple causes of death from the international classification of diseases version 10 (ICD-10) codes for cardiogenic shock (R57.0) mortality in addition to acute ischemic heart disease [I21 (Acute myocardial infarction), I22 (Subsequent myocardial infarction) and I24 (Other ischemic heart disease)] to account for AMICS. Data were obtained from 1999 to 2019 and stratified by age group, sex and race (black vs. white).…”