Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients

Yang, Hui; Qiu, Lihua; Chen, Guangjie; Ye, Zi; Lü, Caijun; Lin, Qi

doi:10.1016/j.fertnstert.2007.03.037

Cited by 171 publications

(132 citation statements)

References 15 publications

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“…The prevalence of Th17 cells in decidual tissue suggests that Th17 cells are involved in sustaining normal pregnancy in humans. The change in Th17 cells is similar to that observed in natural Treg cells during human pregnancy, 6,22,23 and there is a reciprocal interaction between Treg cells and Th17 cells. 9 Therefore, we hypothesized that Th17 cells may act in concert with Treg cells to maintain maternal-fetal tolerance.…”

Section: Discussionsupporting

confidence: 72%

Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17

Jin

et al. 2014

Cell Mol Immunol

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T helper 17 (Th17) cells have both regulatory and protective roles in physiological conditions. The Th17 subset and the cytokine interleukin-17A (IL-17A) have been implicated in the pathogenesis of certain autoimmune diseases, several types of cancer and allograft rejection. However, the role of Th17 cells at the maternal/fetal interface remains unknown. Here, we demonstrate that Th17 cells are present in decidua and are increased in the peripheral blood of 10 clinically normal pregnancies based on intracellular cytokine analysis. Our results suggest a potential role of Th17 cells in sustaining pregnancy in humans. Furthermore, we demonstrate that decidual stromal cells (DSCs) but not trophoblast cells recruit peripheral Th17 cells into the decidua by secreting CCL2. The recruited Th17 cells promote proliferation and invasion and inhibit the apoptosis of human trophoblast cells by secreting IL-17 during the first trimester of pregnancy. These findings indicate a novel role for Th17 cells in controlling the maternal-fetal relationship and placenta development.

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Section: Discussionsupporting

confidence: 72%

Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17

Jin

et al. 2014

Cell Mol Immunol

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“…Heikkinen et al (2004) reported that 10-15% of decidual CD4+ T lymphocytes are CD4+CD25+ T regulatory cells. Both Sasaki et al (2004) and Yang et al (2008) reported an increased percentage of CD25bright cells in the decidual CD4+ population in early pregnancy, compared with that in the peripheral blood CD4+ population from the same subjects, although the proportions of CD25bright cells that were detected differed between the two studies. A greater proportion of CD4+CD25+ cells have been identified in decidua parietalis compared to decidua basalis in both early pregnancy and at term (Tilburgs et al, 2006).…”

Section: Distribution and Functionmentioning

confidence: 94%

“…In women with sporadic miscarriage reduced numbers of decidual CD4+CD25+ T regulatory lymphocytes were observed compared to normal age matched controls (Sasaki et al, 2004). Yang et al (2008) have reported reduced proportions of CD4+ CD25bright cells in decidua in unexplained recurrent miscarriage compared with controls; whereas there was a significant difference between the percentage of CD25bright cells in the decidual and peripheral blood CD4+ populations, no such difference was noted in recurrent miscarriage subjects. Reduced numbers of CD25bright CD4+ regulatory T lymphocytes have also been reported in both peripheral blood and decidua in pre-eclampsia compared with normal pregnancy controls (Sasaki et al, 2007).…”

Section: Regulatory T Lymphocytes In Pathological Pregnancymentioning

confidence: 97%

Immune cells in the placental bed

Bulmer¹,

Williams²,

Lash³

2010

Int. J. Dev. Biol.

305

279

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“…37 Yang et al 45 reported that the proportion of Treg cells in both decidua and peripheral blood in unexplained recurrent spontaneous abortion was significantly lower than those in control women. And the immunosuppressive activity of Treg cells in repeated miscarriage cases have reduced suppressive capacity compared with normal fertile women.…”

Section: Th1/th2/th17 and Treg Paradigms In Normal Pregnancymentioning

confidence: 99%

REVIEW ARTICLE: Th1/Th2/Th17 and Regulatory T‐Cell Paradigm in Pregnancy

Saito

Nakashima

Saito

et al. 2010

American J Rep Immunol

956

833

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Citation Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T‐cell paradigm in pregnancy. Am J Reprod Immunol 2010T‐helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)‐β and interleukin (IL)‐10 or by cell‐to‐cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.

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Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients

Cited by 171 publications

References 15 publications

Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17

Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17

Immune cells in the placental bed

REVIEW ARTICLE: Th1/Th2/Th17 and Regulatory T‐Cell Paradigm in Pregnancy

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