Proportion of pregnancy associated asymptomatic bacteriuria in a tertiary care hospital

Abstract

Background: Urinary tract infections are a common occurrence in pregnancy. The physiological and anatomical changes associated with pregnancy predispose to UTIs. Main aim of the study is to determine the prevalence of asymptomatic bacteriuria in pregnant women, to identify the commonest microorganisms and antibacterial susceptibility of the isolated organism and to study the adverse maternal and fetal outcome.Methods: Prospective cross sectional study, conducted between July 2016 to July 2017 in a tertiary hospital. All pregnant women without the symptoms of UTI attending prenatal checkups were included, they were evaluated with urine microscopy and culture sensitivity.Results: Out of 250 pregnant women, 24 urine samples were contaminated and were excluded from the study.165 pregnant women had sterile culture. 10 women had insignificant bacteruria. 30 women had significant growth on culture. 2 of the culture positive women and 21 culture negative women lost for follows. So total number of culture positive women were 28 so incidence of asymptomatic bacteruria is 13.7%.Conclusions: Routine urine culture sensitivity even in asymptomatic women should be offered during antenatal visits so that adverse maternal and fetal outcomes can be prevented.

Multidrug Resistant Uropathogens among Egyptian Pregnant Women

“…ASB was more prevalent in women of low socioeconomic class (68%) although not statically significant. These findings are similar to those obtained by (Kerure et al, 2012;Bose and Revankar, 2018).…”

“…The antibiotic susceptibility patterns of Gram Negative bacteria showed that meropenem, azreonam and nitrofurantoin were effective in more than half of these isolates. These findings are in agreement with an Indian study (Bose and Revankar, 2018) stated that meropenem was the most sensitive antibiotic (84%), followed by cefaperazone (73.1%) and nitrofurantoin (69.2%). The antibiotic with the overall highest sensitivity pattern in this study was meropenem, however, nitrofurantoin showed an appreciated sensitivity rates in Proteus, morganella, E coli and CoNs, these findings are quite similar to those obtained by (Onoh et al, 2013), so nitrofurantoin could be a good option in the management of UTI in pregnancy, especially when the isolated organism has good sensitivity to nitrofurantoin.…”

“…The effective appropriate antimicrobial agent is a problematic issue in pregnancy as many antimicrobial groups cannot be used; quinolones, tetracylines due to their potential toxicity to the fetus (Matuszkiewicz-Rowińska et al, 2015). With the emergence of drug resistance and particularly the ESBL production by Gram negative bacteria and methicillin resistance in Staphylococcus species, antibiotic options for treating pregnant woman with bacteruria are limited (Thapa et al, 2015;Bose and Revankar, 2018).…”

“…The species of isolated uropathogens are relatively limited, with the eternal leadership of Eschericia coli as a major cause accounting for 75%--90% of uncomplicated UTI isolates. Other players are involved; S. saprophyticus, Klebsiella pneumoniae, Proteus mirabilis and group B Streptococci (Mukherjee et al, 2014;Bose and Revankar, 2018).…”

“…With the emergence of drug resistance and particularly the Extended Spectrum Beta Lactamase (ESBL) production by Gram negative bacteria and Methicillin Resistance in Staphylococcus species (MRSA), antibiotic options for treating pregnant woman with bacteruria become limited (Thapa et al, 2015;Bose and Revankar, 2018). Multidrug-Resistant (MDR) strains are defined as acquired non-susceptibility to at least one agent in three or more antimicrobial categories (Magiorakos et al, 2012).…”