Proportion of neuropathic pain in the back region in chronic low back pain patients -a multicenter investigation

Abstract

Neuropathy can contribute to low back pain (LBP) in the region of the back. Our study investigated the proportion of neuropathic pain (NP) in low back region in chronic LBP patients from multicenter and clinics in China and identified associated factors. Assessment was made using a questionnaire and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS, only tested in low back region), as well as Quantitative Sensory Testing (QST, merely applied to the low back region), the Hospital Anxiety and Depression Scale (HADS) and the Oswestry Disability Index (ODI). Our questionnaire collected demographic information, behavioral habits and medical records. 2116 outpatients over 18 years old complaining of LBP lasting more than 3 months were enrolled in this study. The NP proportion in low back region in chronic LBP patients was 2.8%. Multivariable logistic regression analysis showed that histories of lumbar surgery, abdominal or pelvic surgery, and drinking alcohol were independent positive predictors for LBP of predominantly neuropathic origin (LBNPO), while history of low back sprain and frequently carrying weight as independent negative predictor. Using these parameters may help the identification of patients with chronic LBP likely to develop NP leading to improved treatment outcomes.

Mapping the serum proteome to neurological diseases using whole genome sequencing

“…To explore the biological relevance of the pQTLs, we carried out colocalisation analysis with neuropsychiatric traits using data published by the Psychiatric Genomics Consortium (PGC), as well as other neurodegenerative traits, using publicly available summary statistics from recent large GWAS meta-analyses (Supplementary Data 5b ). We also studied colocalisation with signals for pain-related traits that have been proven to have a neuropathic component, such as chronic back pain 22 and osteoarthritis 23 . A total of 15 protein–trait pairs colocalised with human disease signals, suggesting a role for the protein in mediating disease.…”

Hidden Neuropathic Pain in Chronic Low Back Pain: Prevalence, Pattern, and Impact on Quality of Life

“…Many independent risk factors for NP in CLBP were reported from previous studies, including advanced age 4,7 , female gender 4,7,14 , male gender 9 , pain intensity 9,14 , diabetes mellitus 4,7 , lumbar, abdominal, or pelvic surgery 7,23 , alcohol consumption 23 , Caucasian race 7 , and smoking. 7 The present study found only advanced age to be an independent risk factor for NP, which is consistent with the results of studies conducted by El Sissi, et al 4 and Kaki, et al 7 A review of the literature is shown in Table 5.…”

“…Previous studies reported a prevalence of NP in CLBP that ranged from 1.6% to 80%. 4,[11][12][13]22,23 The wide range of reported prevalence may be explained by differences in sample size, differences in the reference scores and/or type(s) of questionnaires used, and differences in the locations of pain.…”

Validation of the Questionnaire for Symptom Assessment in Pain disorders for Back pain patients (Q‐SAP)

“…One reason for the different signs and symptoms of CLBP might be the involvement of nociceptive and neuropathic pain components (Baron et al., 2016; Bogduk, 2009, IASP Terminology—IASP, n.d.). The stated frequency of neuropathic components in CLBP varies from 2.5% to 54.7%, but strongly depends on the used assessment criteria, assessment tools and investigated patient clientele (Freynhagen et al., 2006; Kaki et al., 2005; Li et al., 2018). Neuropathic pain components in CLBP might have an additional negative influence on the responses to treatments and reduce the quality of life to a greater extent (Beith et al., 2011; Hiyama et al., 2015).…”