Proportion of individuals with anti-Batrachochytrium dendrobatidis skin bacteria is associated with population persistence in the frog Rana muscosa

Lam, Brianna A.; Walke, Jenifer B.; Vredenburg, Vance T.; Harris, Reid N.

doi:10.1016/j.biocon.2009.11.015

Cited by 147 publications

(166 citation statements)

References 18 publications

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“…This difference may be a result of different evolutionary histories of the host and symbiont ). For example, J. lividum has been repeatedly found on R. muscosa in nature, suggesting an evolutionary history together (Woodhams et al 2007;Lam et al 2010;Vredenburg et al 2011). J. lividum has yet to be detected on frog skins during repeated sampling efforts in Panama (M. H. Becker, unpublished results).…”

Section: Discussionmentioning

confidence: 99%

Towards a Better Understanding of the Use of Probiotics for Preventing Chytridiomycosis in Panamanian Golden Frogs

et al. 2011

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Populations of native Panamanian golden frogs (Atelopus zeteki) have collapsed due to a recent chytridiomycosis epidemic. Reintroduction efforts from captive assurance colonies are unlikely to be successful without the development of methods to control chytridiomycosis in the wild. In an effort to develop a protective treatment regimen, we treated golden frogs with Janthinobacterium lividum, a skin bacterium that has been used to experimentally prevent chytridiomycosis in North American amphibians. Although J. lividum appeared to colonize A. zeteki skin temporarily, it did not prevent or delay mortality in A. zeteki exposed to Batrachochytrium dendrobatidis, the causative agent of chytridiomycosis. After introduction of J. lividum, average bacterial cell counts reached a peak of 1.7 9 10 6 cells per frog *2 weeks after treatment but declined steadily after that. When J. lividum numbers declined to *2.8 9 10 5 cells per frog, B. dendrobatidis infection intensity increased to greater than 13,000 zoospore equivalents per frog. At this point, frogs began to die of chytridiomycosis. Future research will concentrate on isolating and testing antifungal bacterial species from Panama that may be more compatible with Atelopus skin.

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Section: Discussionmentioning

confidence: 99%

Towards a Better Understanding of the Use of Probiotics for Preventing Chytridiomycosis in Panamanian Golden Frogs

et al. 2011

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“…One example is the cutaneous bacterium Janthinobacterium lividum, which produces the antifungal metabolite violacein, reported to inhibit Bd growth in lab assays [ 33,34 ]. Furthermore, bioaugmentation experiments with two amphibian species, Plethodon cinereus [ 7 ] and Rana mucosa [ 7 ], have demonstrated that violacein effects Bd infectivity and virulence when individuals are inoculated with Bd at low concentrations.…”

Section: Aq4mentioning

confidence: 99%

Dietary Carotenoid Supplementation Enhances the Cutaneous Bacterial Communities of the Critically Endangered Southern Corroboree Frog (Pseudophryne corroboree)

et al. 2016

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. (2017). Dietary carotenoid supplementation enhances the cutaneous bacterial communities of the critically endangered southern corroboree frog (Pseudophryne corroboree). Microbial Ecology: an international journal, 73 (2), 435-444.Dietary carotenoid supplementation enhances the cutaneous bacterial communities of the critically endangered southern corroboree frog (Pseudophryne corroboree) AbstractThe rapid spread of infectious disease has resulted in the decline of animal populations globally. Amphibians support a diversity of microbial symbionts on their skin surface that help to inhibit pathogen colonisation and reduce disease susceptibility and virulence. These cutaneous microbial communities represent an important component of amphibian immune defence, however, very little is known about the environmental factors that influence the cutaneous microbiome. Here, we characterise the cutaneous bacterial communities of a captive colony of the critically endangered Australian southern corroboree frog, Pseudophyrne corroboree, and examine the effect of dietary carotenoid supplementation on bacterial abundance, species richness and community composition. Individuals receiving a carotenoid-supplemented diet exhibited significantly higher bacterial abundance and species richness as well as an altered bacterial community composition compared to individuals that did not receive dietary carotenoids. Our findings suggest that dietary carotenoid supplementation enhances the cutaneous bacteria community of the southern corroboree frog and regulates the presence of bacteria species within the cutaneous microbiome. Our study is the second to demonstrate that carotenoid supplementation can improve amphibian cutaneous bacterial community dynamics, drawing attention to the possibility that dietary manipulation may assist with the ex situ management of endangered species and improve resilience to lethal pathogens such as Batrachochytrium dendrobatidis (Bd).

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“…Recent work [79] has demonstrated that the growth of Bd in vitro can be strongly moderated by antimicrobial metabolites secreted by a wide range of bacteria that are resident on amphibian skin. Bacteria can also affect the course and outcome of chytridiomycosis caused by experimental inoculations of amphibians with Bd [80,81], and the prevalence of potentially mutualistic bacteria may affect the ability of populations of some amphibians to persist when Bd first appears [10,82].…”

Section: Emerging Diseases Of Wildlifementioning

confidence: 99%

Context-dependent symbioses and their potential roles in wildlife diseases

Daskin

Alford

2012

Proc. R. Soc. B.

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It is well known in ecology, evolution and medicine that both the nature (commensal, parasitic and mutualistic) and outcome (symbiont fitness, survival) of symbiotic interactions are often contextdependent. Less is known about the importance of context-dependence in symbioses involved in wildlife disease. We review variable symbioses, and use the amphibian disease chytridiomycosis to demonstrate how understanding context-dependence can improve the understanding and management of wildlife diseases. In chytridiomycosis, the host-pathogen interaction is context-dependent; it is strongly affected by environmental temperature. Skin bacteria can also modify the interaction; some bacteria reduce amphibians' susceptibility to chytridiomycosis. Augmentation of protective microbes is being considered as a possible management tool, but informed application of bioaugmentation requires understanding of how the interactions between host, beneficial bacteria and pathogen depend upon environmental context. The community-level response of the amphibian skin microbiota to environmental conditions may explain the relatively narrow range of environmental conditions in which past declines have occurred. Environmental context affects virulence and the protection provided by mutualists in other host-pathogen systems, including threatened bats and corals. Increased focus on context-dependence in interactions between wildlife and their symbionts is likely to be crucial to the future investigation and management of emerging diseases of wildlife.

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Proportion of individuals with anti-Batrachochytrium dendrobatidis skin bacteria is associated with population persistence in the frog Rana muscosa

Cited by 147 publications

References 18 publications

Towards a Better Understanding of the Use of Probiotics for Preventing Chytridiomycosis in Panamanian Golden Frogs

Towards a Better Understanding of the Use of Probiotics for Preventing Chytridiomycosis in Panamanian Golden Frogs

Dietary Carotenoid Supplementation Enhances the Cutaneous Bacterial Communities of the Critically Endangered Southern Corroboree Frog (Pseudophryne corroboree)

Context-dependent symbioses and their potential roles in wildlife diseases

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