Proportion of Healed Teeth With Apical Periodontitis Medicated With Two Percent Chlorhexidine Gluconate Liquid: A Case-Series Study

The Effect of Addition of an EPS Degrading Enzyme with and without Detergent to 2% Chlorhexidine on Disruption of Enterococcus faecalis Biofilm: A Confocal Laser Scanning Microscopic Study

“…In the field of endodontics, CHX has been used as an irrigant with proven substantivity because of its ability to adhere to hydroxyapatite of dentin [33,34] and its effectiveness against endodontic pathogens. However, biofilms within root canals are resistant to the antibacterial effect of CHX.…”

Development of an Ex Vivo Coculture System to Model Pulpal Infection by Streptococcus anginosus Group Bacteria

“…Calcium hydroxide is the more commonly used treatment for pulpal wounds as its high pH is thought to have a general antibacterial effect whilst encouraging pulpal repair (Desai and Chandler 2009;El Karim et al 2007). However, since the introduction of calcium hydroxide in the early 20th century, many other compounds with more specific antimicrobial and anti-inflammatory properties have been developed (Tervit et al 2009). These include substances such as antimicrobial peptides and triclosan and may be of clinical significance.…”

The Microbial Challenge to Pulp Regeneration

“…Clinical studies have shown that it is effective when used with 1% hypochlorite solution (Zamany et al, 2003), and in vitro studies have shown superiority compared with calcium hydroxide usage or controls (Cook et al, 2007). However, other studies have not corroborated its absolute efficacy as an irrigant or a medicament between appointments (Manzur et al, 2007;Paquette et al, 2007;Tervit et al, 2009). Chlorhexidine also interfered with cell attachment to dentin in vitro, although not to the same extent as hypochlorite (Ring et al, 2008).…”