Propolis research and the chemistry of plant products

Salatino, Antônio; Fernandes-Silva, Caroline C.; Righi, Adne Abbud; Salatino, Maria Luiza Faria

doi:10.1039/c0np00072h

Cited by 248 publications

(292 citation statements)

References 132 publications

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“…Recently, studies have been published on the known biological activities of CAPE as well as on the activities of other compounds as well studied as Artepillin C than the discovery of new components isolated from propolis from different regions, showing perspectives on propolis and its individual components for medicine (Aviello et al, 2010;Salatino et al, 2011).…”

Section: Anti-inflammatory and Immunomodulatory Response To Isolated mentioning

confidence: 99%

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/ or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters), terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an antiinflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

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Section: Anti-inflammatory and Immunomodulatory Response To Isolated mentioning

confidence: 99%

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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“…The propolis chemical composition varies greatly with the plant origin of the resin and thus with the geographic and climatic characteristics of the site (Bankova, 2005). The specificity of local flora is very important, not all plants are resin providers and bees have a marked preference for one or a few sticky resin sources, which are, at the same time sources of biologically active phytochemicals (Salatino et al, 2011). Based on this knowledge, propolis was typified according to their plant origin and its main chemical constituents (Bankova, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…C-prenylflavonoids (or propolins) have been described in propolis from Pacific islands, where the resin sources are the fruit exudates of the tree Macaranga tanarius (Chen et al, 2003). The propolis typification on the basis of plant sources knowledge is a useful tool for its chemical standardization and thus for ensuring the quality and safety necessary for its commercialization (Bankova, 2005;Salatino et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Phenolic quantification and botanical origin of Portuguese propolis

Falcão

Tomás

Vale

et al. 2013

Industrial Crops and Products

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a b s t r a c tThe production of propolis by honeybees results from a selective collection of exudates from leaf buds and plants present in the hive neighborhood leading to a resin with many potentialities in the pharmaceutical industry. This study aims to quantify the phenolic content in propolis from different Portuguese regions and in the potential floral sources, Populus x Canadensis Moench buds and Cistus ladanifer L., in order to establish links with geographical and botanical origin.The Portuguese propolis revealed a phenolic profile with marked differences in concentrations: the richness in flavonoids is common in all regions, but more evident in propolis from central interior, south and Madeira. The composition of poplar type propolis common in temperate zones was observed in the north, central coast and Azores, while the central interior and south samples, with a composition rich in kaempferol derivatives, resemble the C. ladanifer exudates, a spontaneous bush widespread in the Mediterranean. The compound kaempferol-3,7-dimethyl-ether, absent in the poplar type propolis, can be regard as a possible marker for the discrimination of these two types of propolis.

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“…4 Propolis is a resinous product containing secretions from bees and plant resins, whose composition depends on the regional climate, flora, and time of year in which it is collected. 9 There are different types of propolis that are characterized and classified according to their chemical composition. 9 More than 300 components have been identified, including phenolic compounds, such as flavonoids, phenolic acids, and phenolic acid esters, the main components of propolis from temperate regions.…”

Section: Introductionmentioning

confidence: 99%

“…9 There are different types of propolis that are characterized and classified according to their chemical composition. 9 More than 300 components have been identified, including phenolic compounds, such as flavonoids, phenolic acids, and phenolic acid esters, the main components of propolis from temperate regions. 10 Among tropical countries, Brazil has the highest chemical diversity of propolis types, such as those that contain phenylpropanoids, prenylated phenylpropanoids (e.g., artepillin C), and sesqui-and diterpenoids, 11 which confer immunostimulatory, antioxidant, anti-inflammatory, and antimicrobial properties, respectively.…”

Section: Introductionmentioning

confidence: 99%

In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis

et al. 2015

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The aim of this study was to evaluate the in vitro antimicrobial activity of Brazilian brown propolis as an intracanal medication against Enterococcus faecalis. Thirty dentin discs prepared from intact freshly extracted bovine maxillary central incisors were infected with E. faecalis for 21 days. The specimens were distributed into six groups according to the medicament used as follows: G1-calcium hydroxide paste; G2-Carbowax 400 (control group); G3-20% brown propolis paste; G4-40% brown propolis paste; G5-20% brown propolis paste + calcium hydroxide paste; and G6-40% brown propolis paste + calcium hydroxide paste. The experimental pastes were placed into the canal lumen and left for 14 days. After each period, irrigation was performed with sterile saline to remove the medicament, and the canals were dried with sterile paper points. The dentin chips were removed from the canals with sequential sterile round burs at low speed and were immediately collected in separate test tubes containing BHI broth. The tubes were incubated at 37°C, and microbial growth was analyzed by spectrophotometry after 15 days. All the experimental medications significantly reduced the number of viable bacteria. The G4 and G5 pastes were more effective than the G1 paste, with 35.8%, 41%, and 21.3% antibacterial activity, respectively. Brazilian brown propolis shows antibacterial capacity against E. faecalis.

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Propolis research and the chemistry of plant products

Cited by 248 publications

References 132 publications

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Phenolic quantification and botanical origin of Portuguese propolis

In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis

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