Propolis Potentiates Methotrexate Anticancer Mechanism and Reduces its Toxic Effects

Salem, Maha M.; Donia, Thoria; Abu-Khudir, Rasha; Ramadan, Haitham; Ali, Ehab M.M.; Mohamed, Tarek M.

doi:10.1080/01635581.2019.1640884

Cited by 19 publications

(14 citation statements)

References 54 publications

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“…Oršolić et al [68] administered propolis (50 mg/kg, ip) 7 and 3 days before inoculation of the Ehrlich ascites tumor (EAT) cells (2 × 10 6 , ip) in mice, and then applied the cisplatin (5 or 10 mg/kg, ip) 3 days after the inoculation of EAT cells at 37 • C and 43 • C. After the experimental period, they reported that the combination of propolis + cisplatin 5 mg/kg at 37 • C resulted in tumor growth inhibition and increased the survival of mice; propolis also reduced the toxic and genotoxic effect of cisplatin on normal cells without affecting the cytotoxicity of cisplatin on EAT cells. In another study, which was designed to investigate the in vitro anticancer effect of propolis ethanolic extract (PEE) and its protective role against methotrexate (MTX) toxicity in the Ehrlich acid carcinoma (EAC) experimental model, Salem et al [69] reported that the PEE prompted cytotoxic effects in cancer cell lines and antitumor effects against the EAC mice model by reducing the tumor volume and count of viable tumor cells, with a significant increase in the life period of mice. Production of NP and its utilization in cancer cases are a new approach together with the progress of nanotechnology.…”

Section: Discussionmentioning

confidence: 99%

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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This study was performed to determine the effects of chitosan-coated nano-propolis (NP), which is synthesized via a green sonochemical method, and propolis on the side effects of cisplatin (CP), which is a widely used drug in the treatment of cancer. For this aim, 56 rats were divided into seven groups, balancing their body weights (BW). The study was designed as Control, CP (3 mg/kg BW at single dose of CP as intraperitoneal, ip), Propolis (100 mg/kg BW per day of propolis by gavage), NP-10 (10 mg/kg BW of NP per day by gavage), CP + Propolis (3 mg/kg BW of CP and 100 mg/kg BW of propolis), CP + NP-10 (3 mg/kg CP and 10 mg/kg BW of NP), and CP + NP-30 (3 mg/kg BW of CP and 30 mg/kg BW of NP). Propolis and NP (especially NP-30) were preserved via biochemical parameters, oxidative stress, and activation of apoptotic pathways (anti-apoptotic protein: Bcl-2 and pro-apoptotic protein: Bax) in liver and kidney tissues in the toxicity induced by CP. The NP were more effective than propolis at a dose of 30 mg/kg BW and had the potential to ameliorate CP’s negative effects while overcoming serious side effects such as liver and kidney damage.

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Section: Discussionmentioning

confidence: 99%

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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“…In turn, ethanolic extract of Turkish propolis has been shown to have cytotoxic activity towards hormone-resistant prostate cancer PC-3 cells [ 81 ]. Egyptian propolis ethanolic extract prompted cytotoxic effects in HCT-116 (colon cancer), MDA-MB-231, MCF-7, and HeLa (cervical cancer) cancer cell lines [ 82 ]. Mexican brown propolis ethanolic extract cytotoxic activity was evaluated in a rat C6 glioma cell and human cervical cancer cell lines (HeLa, SiHa, and CaSki) [ 56 ].…”

Section: Mechanisms Of Anticancer Activity Of Propolis and Its Compoundsmentioning

confidence: 99%

“…Apoptosis induction by propolis and its compounds coming from different geographical regions has been proven in many studies [ 19 , 55 , 59 , 61 , 67 , 79 , 82 , 87 , 88 , 89 , 90 , 91 , 92 ], while in this review, we want to focus strictly on the demonstrated molecular mechanisms of this process.…”

Section: Mechanisms Of Anticancer Activity Of Propolis and Its Compoundsmentioning

confidence: 99%

Anticancer Activity of Propolis and Its Compounds

Forma

Bryś

2021

Nutrients

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Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer is one of the major burdens of disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents and treatments for cancer. Propolis is a rich source of biologically active compounds, which affect numerous signaling pathways regulating crucial cellular processes. The results of the latest research show that propolis can inhibit proliferation, angiogenesis, and metastasis of cancer cells and stimulate apoptosis. Moreover, it may influence the tumor microenvironment and multidrug resistance of cancers. This review briefly summarizes the molecular mechanisms of anticancer activity of propolis and its compounds and highlights the potential benefits of propolis to reduce the side effects of chemotherapy and radiotherapy.

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“…Propolis is used for therapeutic purposes since ancient times [5]. Nowadays, several studies shed light on the biological activities of propolis, such as antimicrobial [6,7], antiinflammatory [8], antiviral [9], hepatoprotective [10], immunomodulatory [11], antioxidant [12,13], and anticancer activities [14].…”

Section: Introductionmentioning

confidence: 99%

Influence of Geographic Origin and Plant Source on Physicochemical Properties, Mineral Content, and Antioxidant and Antibacterial Activities of Moroccan Propolis

Menyiy

Bakour

Guendouz

et al. 2021

International Journal of Food Science

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This research is aimed at determining the physicochemical properties (resin, wax, balsams, pH, moisture, ash, and mineral contents) of propolis samples collected from different geographical areas in Morocco, as well as evaluating the antioxidant and antibacterial activities of these samples. The results showed the following values for physicochemical analysis: resin (17.42-58.01%), wax (21.31-70.12%), balsam (0.27-2.12%), pH (3.7-5.3), moisture (1.02-3.65%), and ash (0.72-5.01%). The phenolic and flavone/flavonol contents of samples were ranged between 6.74 mg FAE/g and 149.13 mg FAE/g and between 1.19 mg QE/g and 108.11 mg QE/g, respectively. The sample P3 presented also the strongest radical scavenging activity toward DPPH, ABTS free radicals, and FRAP assay with IC50 values of 0.021, 0.026, and 0.042 mg/mL, respectively. All propolis samples showed significant inhibitory effects against all tested microorganisms with MICs ranging from 0.28 mg/mL to 1.12 mg/mL for Gram-negative strains and from 0.002 mg/mL to 1.12 mg/mL for Gram-positive strains. A strong correlation was found between resin, total phenolic compounds, flavones/flavonols, and antioxidant activity. Linear discriminant analysis revealed that the samples studied were divided into two groups which were differentiated by the data of antioxidant activity, mineral contents, and antibacterial activity. It can be concluded that the physicochemical properties, mineral content, and biological activities of Moroccan propolis depend on their geographical and botanical origin.

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Propolis Potentiates Methotrexate Anticancer Mechanism and Reduces its Toxic Effects

Cited by 19 publications

References 54 publications

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Anticancer Activity of Propolis and Its Compounds

Influence of Geographic Origin and Plant Source on Physicochemical Properties, Mineral Content, and Antioxidant and Antibacterial Activities of Moroccan Propolis

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