Propolis of stingless bees: A phytochemist's guide through the jungle of tropical biodiversity

Popova, Milena; Trusheva, Boryana; Bankova, Vassya

doi:10.1016/j.phymed.2019.153098

Cited by 68 publications

(87 citation statements)

References 65 publications

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“…However, the literature reports of the discovery of HBP compositions were relatively small prior to 1996, with a significant increase since 2010 ( Figure 3 ). Potentially, this increase in interest was stimulated by the scientific validation of the pharmacological properties of HBP during the late 1990s and early 2000s [ 30 ]. Up to December 2019, there were 502 different natural products isolated and characterised from materials collected in 40 countries ( Figure 4 and Figure 5 C, and Supporting Information 2 ).…”

Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

“…with polyprenylated acylphloroglucinols; (d) sub-tropical and tropical Pacific propolis derived from Macaranga spp., with geranyl flavonoids; and (e) Greek, Cretan, and Turkish propolis (Mediterranean region) with either diterpenoids or anthraquinones. Several reviews of SBP reported the chemical compositions and their biological activities [ 29 , 30 , 166 ]. However, most of the compounds reviewed were identified by HPLC, GC-MS, and LC-MS.…”

Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

“…Several comprehensive reviews have reported the natural compositions found in propolis [ 13 , 17 , 20 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ] and their biological activities [ 13 , 14 , 16 , 22 , 23 , 24 , 31 , 32 , 33 , 34 , 35 ]. However, the chemical space and the chemical diversity of propolis components have been underexplored.…”

Section: Introductionmentioning

confidence: 99%

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Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Tran

Ogbourne

Brooks

et al. 2020

IJMS

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Propolis is a natural resinous material produced by bees and has been used in folk medicines since ancient times. Due to it possessing a broad spectrum of biological activities, it has gained significant scientific and commercial interest over the last two decades. As a result of searching 122 publications reported up to the end of 2019, we assembled a unique compound database consisting of 578 components isolated from both honey bee propolis and stingless bee propolis, and analyzed the chemical space and chemical diversity of these compounds. The results demonstrated that both honey bee propolis and stingless bee propolis are valuable sources for pharmaceutical and nutraceutical development.

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Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

Section: Propolis Components: Chemistry and Geographical Distributmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Tran

Ogbourne

Brooks

et al. 2020

IJMS

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“…This negligible difference may be attributed to the variations of the quantities and qualities of active compounds found in the propolis extract due to climate differences, variety of plant sources from different geographical locations, as well as the different viability testing techniques. However, a recent report has suggested that propolis is made of a vast chemical variability thus requiring pharmacological studies using chemically characterized propolis components 23 . Thus, further compositional characterization of propolis is needed to address the pharmacological effects of propolis associated with its identified chemical gradients to better understand the main mechanism of action which Thai propolis extract utilizes in preserving PDL cells.…”

Section: Discussionmentioning

confidence: 99%

Preservation of the viability and gene expression of human periodontal ligament cells by Thai propolis extract

Bunwanna

Damrongrungruang

Puasiri

et al. 2020

Dental Traumatology

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Background/Aim: Success of tooth replantation depends on the quality and quantity of periodontal ligament (PDL) cells. The aims of this study were to evaluate Thai propolis extract as a storage medium for maintaining PDL cell viability and preserving gene expressions in PDL tissues. Materials and Methods: PDL cells from human premolars were tested for cytotoxicity of the extract by PrestoBlue assay to determine a non-toxic concentration. Subsequently, 96 freshly extracted premolars were allocated into different treatment groups. Control groups were freshly extracted premolars or they had been stored dry for 12 hours. Experimental avulsed teeth were created by leaving them air-dried for 30 minutes immediately after extraction, then they were immersed in Thai propolis extract, HBSS or milk for 3, 6 and 12 hours. After tooth storage, the remaining PDL cells were determined for their cell viability. RNA isolated from PDL tissues of three premolars treated similarly was analysed for periostin and S100A4 expressions using RT-qPCR. Results: Thai propolis extract at 0.625 mg mL −1 promoted the greatest PDL cell viability. Tooth storage in 0.625 mg mL −1 Thai propolis extract, HBSS or milk showed no difference in maintaining cell viability. Periostin mRNA level was preserved by Thai propolis extract. Expression of S100A4 mRNA in PDL tissues stored in all tested media was dampened. Conclusions: PDL cells from mock avulsed teeth stored in 0.625 mg mL −1 Thai propolis extract for 3, 6 and 12 hours remained viable and the expression of periostin was preserved. This study suggests this extract as an alternative for a tooth storage medium for up to 12 hours. However, transporting an avulsed tooth in a storage medium for extended extra-oral time might affect the PDL cell phenotypes.

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“…In recent years scientists have been putting growing attention to natural products, such as tea leaves and honeybee product called propolis; actually, these products have shown considerable antibacterial, antifungal, antiviral, anti-inflammatory and antioxidant activity, due to their high content of polyphenols and flavonoids as well as their derivatives [1,2]. Propolis is a natural resin collected by honeybees from plant parts and subsequently elaborated by them in order to seal and protect beehives [3].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of UV-Curable Acrylic Membranes Embedding Natural Antioxidants

Rajczak

Tylkowski²,

Constantí

et al. 2020

Polymers

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We examine the behaviour of acrylic resin-based membranes containing natural anti-oxidants, such as Galla chinensis tea powder extract (TP) and Taiwanese green propolis (TGP), in different concentrations ranging between 5 and 20 wt %. Membrane morphology was investigated by means of Environmental Scanning Electron Microscopy (ESEM), while the UV-curing reaction was monitored by Fourier-Transform Infra-red (FTIR) spectroscopy. In most cases Thermogravimetric (TG), Differential Scanning Calorimetric (DSC) and Dynamo-mechanical Thermal (DMT) analyses showed that the desirable characteristics of the UV-cured acrylic resin are not substantially altered by the presence of the organic fillers. The release kinetics of polyphenols and flavonoids, determined in water for TP-containing membranes (ETx) and in ethanol/water mixture (7:3 v/v) for TGP-containing ones (EPx), was satisfactory, reaching a plateau after 24 h. Finally, preliminary antibacterial tests against S. epidermidis were performed on the membranes with higher additive amount and gave positive results for ET-type; on the contrary, no inhibitory effect was observed for the tested EP-type membranes.

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Propolis of stingless bees: A phytochemist's guide through the jungle of tropical biodiversity

Cited by 68 publications

References 65 publications

Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Preservation of the viability and gene expression of human periodontal ligament cells by Thai propolis extract

Preparation and Characterization of UV-Curable Acrylic Membranes Embedding Natural Antioxidants

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