Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

Olczyk, Paweł; Komosińska-Vassev, Katarzyna; Wisowski, Grzegorz; Mencner, Łukasz; Stojko, Jerzy; Koźma, Ewa M

doi:10.1155/2014/748101

Cited by 42 publications

(35 citation statements)

References 46 publications

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“…On the other hand, reports show that natural wound dressing, with controlled release of the bioactive compounds existing in them, enhance the biological properties of such substances, such as antimicrobial and anti‐inflammatory properties, and improve granulation tissues and epithelialization . Among natural products, propolis, a natural bioactive compound made by honey bees with remarkable antimicrobial, anti‐inflammatory, and anti‐oxidant properties can serve as a good candidate for treating burn wounds . Polyphenolic compounds in propolis are able to destroy free radicals existing in burn wounds and thus reduce the inflammation and increase the activity of macrophages in removing the dead cells from the wound surface and consequently reduce the wound healing period .…”

Section: Introductionmentioning

confidence: 99%

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

Zeighampour

Alihosseini

Morshed

et al. 2017

J of Applied Polymer Sci

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Propolis as a natural antibacterial agent was incorporated into the poly(vinyl alcohol) (PVA) in different forms of nanofiber, microfiber, and film. The successful fabrication of uniform nanofibers with 85-314 nm diameters and microfibers with 2.02 lm diameter was proved by scanning electron microscopy. Structural analysis by Fourier transform infrared spectroscopy and X-ray diffraction and swelling properties confirmed the formation PVA hydrogel and its H-bonding to the propolis. Evaluation and comparison of antimicrobial properties of produced samples against Staphylococcus aureus strains revealed that nanofiber mat with 19 mm inhibition zone has 11.76 and 26.67% higher efficiency against bacteria than microfiber mat and film with 17 and 15 mm inhibition zone, respectively. Nanofibrous mat showed sustained release during 96 h by maintaining full antibacterial activity up to 51 h which is of great importance in burn wounds. These results confirm the advanced performance of natural propolis in the form of nanofiber substrate as wound dressing.

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Section: Introductionmentioning

confidence: 99%

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

Zeighampour

Alihosseini

Morshed

et al. 2017

J of Applied Polymer Sci

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“…Several therapeutic strategies have been used to improve the healing of burns lesions, including topical treatment with phytotherapeutic agents [9,10], silver sulphadiazine [11,12] and microcurrent stimulation [13]. Skin grafts, tissue engineering and stem cells therapies [14] are also used for handling of burn injuries.…”

Section: Introductionmentioning

confidence: 99%

InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries

Catarino¹,

Godoy²,

Scharlack³

et al. 2015

Lasers Med Sci

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Therapies that accelerate the healing of burn injuries, improving the quality of life of the patient and reducing the cost of treatment are important. This study evaluated the effects of InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis leaves on burn wound healing in rats. Seventy-two rats were divided randomly into four groups: control untreated (C), treated with InGaP 670-nm laser with power density of 0.41 W/cm(2) and energy density of 4.93 J/cm(2) (L), treated with S. chilensis extract (S) and treated with S. chilensis extract and laser (LS). Second-degree burns were produced on the back of the animals with metal plate. Wound samples were collected on days 7, 14 and 21 of treatment for structural analysis, morphometry and Western blotting to quantify the expression of transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). The results showed that InGaP laser irradiation at 670 nm alone and combined with extract of S. chilensis promoted significant tissue repair responses in this experimental model, increasing the number of fibroblasts, collagen fibres and newly formed blood vessels throughout the experimental period and decreasing the number of granulocytes in burn wounds of second degree in all treated groups. Exclusive treatment of burn wounds with the hydroalcoholic extract of S. chilensis provided similar quantitative results to those seen in the untreated group throughout the experimental period. Therefore, it was observed in the L and LS groups different responses in the expression of TGF-β1 and VEGF. The application of 670-nm laser alone or combined with the extract of S. chilensis promoted favourable responses in tissue repair of second-degree burns in this experimental model.

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“…Leishmania causes high inflammatory and propolis has antioxidant and anti-inflammatory properties that may lead to healing wounds such as cutaneous leishmaniasis (7,(13)(14)(15). Indeed, different activities of propolis including enhancing the expression of collagens Type I and III (16,17) and IFNγ (16), influencing the elimination or reduction of fibrosis development (17), decreasing the release of fibronectin (18), forming biocellulose membranes (10), stimulating natural killer cells, and influencing the release of nitric acid and tumor necrosis factors from macrophages (4) have been reported to help the tissue repair or heal cutaneous leishmaniasis.…”

Section: Discussionmentioning

confidence: 99%

Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo

Tavakoli

Shaddel

Yakhchali

et al. 2020

Ann Mil Health Sci Res

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Background: Propolis is produced by honey bees from plants, buds, and exudates and as an antiseptic is used to treat several diseases, such as acne and wounds. Objectives: Due to some difficulty in the treatment of cutaneous leishmaniasis, the aim of this study was to evaluate the propolis extract function against Leishmania major.Methods: Different concentrations (9.375, 18.75, 37.5, 75, 150, and 300 µg/mL) of both Ethanolic Extract of Propolis (EEP) and the standard drug (Glucantime) were prepared for the in vitro model, and then applied to the fixed number of promastigotes. The promastigotes were counted after 24, 48, and 72-h treatment. Then, the viability of promastigotes was tested by MTT after 72 h of treatment. Twenty mice with cutaneous leishmaniasis were divided into four groups for in vivo model, including a positive group (treatment with Glucantime), a negative group (without treatment), and two experimental groups (treatment with EEP 1% and 4%). The sizes of the ulcers were measured at the beginning of the experiment and weekly for four weeks. Results: The in vitro model indicated that both EEP and Glucantime reduced the number of promastigotes and the difference between EEP and Glucantime was not significant at concentrations 37.5, 75, 150, and 300 µg/mL. The in vivo model demonstrated that EEP 4% and Glucantime were similar and decreased the size of ulcers more significantly than the negative control and EEP 1% (P < 0.05). Conclusions: Propolis as an herbal drug had antileishmanial activity against Leishmania major in vitro and in vivo. We suggest using it for complementary treatment.

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Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

Cited by 42 publications

References 46 publications

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

Comparison of prolonged antibacterial activity and release profile of propolis‐incorporated PVA nanofibrous mat, microfibrous mat, and film

InGaP 670-nm laser therapy combined with a hydroalcoholic extract of Solidago chilensis Meyen in burn injuries

Antileishmanial Effects of Propolis Against Leishmania major In Vitro and In Vivo

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