Propolis loaded liposomes: evaluation of antimicrobial and antioxidant activities

Aytekin, Ayşegül Aylin; Tanrıverdi, Sakine Tuncay; Köse, Fadime Aydın; Kart, Didem; Eroğlu, İpek; Özer, Özgen

doi:10.1080/08982104.2019.1599012

Cited by 37 publications

(37 citation statements)

References 49 publications

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“…These admixtures are removed during technological processing, and the ethanolic extract of propolis (EEP), obtained as a result of extraction, is a rich set of biologically active substances, including flavonoids, phenolic acids and their esters, lipid-wax substances, bioelements and others [ 1 ]. Therefore, propolis shows antibacterial, antioxidant, anti-inflammatory, antidiabetic, antiallergic, immunomodulatory and anticancer properties [ 10 , 11 , 12 ]. The anticancer potential ingredients have been identified as caffeic acid phenethyl ester, chrysin, artepillin C, galangin, etc.…”

Section: Introductionmentioning

confidence: 99%

Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products

et al. 2021

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Bee products have been known for centuries for their versatile healing properties. In recent decades they have become the subject of documented scientific research. This review aims to present and compare the impact of bee products and their components as antimicrobial agents. Honey, propolis, royal jelly and bee venom are bee products that have antibacterial properties. Sensitivity of bacteria to these products varies considerably between products and varieties of the same product depending on their origin. According to the type of bee product, different degrees of activity were observed against Gram-positive and Gram-negative bacteria, yeasts, molds and dermatophytes, as well as biofilm-forming microorganisms. Pseudomonas aeruginosa turned out to be the most resistant to bee products. An analysis of average minimum inhibitory concentration values for bee products showed that bee venom has the strongest bacterial effectiveness, while royal jelly showed the weakest antibacterial activity. The most challenging problems associated with using bee products for medical purposes are dosage and safety. The complexity and variability in composition of these products raise the need for their standardization before safe and predictable clinical uses can be achieved.

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Section: Introductionmentioning

confidence: 99%

Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products

et al. 2021

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“…Special attention should be paid to the characterization of the SLM by using various analytical tools. While the research on various types of lipid dispersions is based on commonly conducted studies of particle size distributions (laser diffraction method or dynamic light scattering), microscopic observations, pH or zeta potential [ 14 , 15 , 16 , 17 , 18 ], the choice of more advanced research techniques is less obvious. The utilization of modern high-resolution analytical techniques might provide an opportunity for an in-depth study of the changes and processes that occur in the SLM formulations during preparation and long-term storage.…”

Section: Introductionmentioning

confidence: 99%

Analytical Techniques for the Assessment of Drug-Lipid Interactions and the Active Substance Distribution in Liquid Dispersions of Solid Lipid Microparticles (SLM) Produced de novo and Reconstituted from Spray-Dried Powders

et al. 2020

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Solid lipid microparticles (SLM) can be presented as liquid suspension or spray-dried powder. The main challenge in SLM technology is to precisely determine the location of the active substance (API) in the different compartments of the formulation and its changes during SLM processing. Therefore, the purpose of the research was to assess the distribution of the API and to investigate the nature of the API-lipid interaction when the formulation was subjected to spray drying, with an indication of the most suitable techniques for this purpose. SLM were prepared with two various lipids (Compritol or stearic acid) and two model APIs: cyclosporine (0.1% and 1% w/w) and spironolactone (0.1% and 0.5% w/w). Physicochemical characterizations of the formulations, before and after spray drying, were performed by differential scanning calorimetry (DSC), atomic force microscopy (AFM), Raman spectroscopy and nuclear magnetic resonance (NMR). The API distribution between the SLM matrix, SLM surface and the aqueous phase was determined, and the release study was performed. It was demonstrated that, in general, the spray drying did not affect the drug release and drug distribution; however, some changes were observed in the SLM with Compritol and when the API concentration was lower. Only in the SLM with stearic acid was a change in the DSC curves noted. Measurements with the AFM technique proved to be a useful method for detecting differences in the surface properties between the placebo and API-loaded SLM, while the Raman spectroscopy did not show such evident differences.

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“…Recently developed formulations for wound treatment based on bee products are summarized in Table 1 . Most of them are prepared with propolis or honey to enhance the wound healing effect [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 ]. Prior to clinical evaluation of these wound-healing formulations, acceptability and efficacy must be assessed in comparison with conventional treatment options.…”

Section: Health Benefits Of Bee Products With Focus On Regenerative Medicinementioning

confidence: 99%

Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing

Peršurić

Pavelić

2021

Molecules

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In recent years, interest has surged among researchers to determine compounds from bee products such as honey, royal jelly, propolis and bee pollen, which are beneficial to human health. Mass spectrometry techniques have shown that bee products contain a number of proven health-promoting compounds but also revealed rather high diversity in the chemical composition of bee products depending on several factors, such as for example botanical sources and geographical origin. In the present paper, we present recent scientific advances in the field of major bioactive compounds from bee products and corresponding regenerative properties. We also discuss extracellular vesicles from bee products as a potential novel bioactive nutraceutical component. Extracellular vesicles are cell-derived membranous structures that show promising potential in various therapeutic areas. It has been extensively reported that the use of vesicles, which are naturally formed in plant and animal cells, as delivery agents have many advantages. Whether the use of extracellular vesicles from bee products represents a new solution for wound healing remains still to be elucidated. However, promising results in specific applications of the bee products in wound healing and tissue regenerative properties of extracellular vesicles provide a good rationale to further explore this idea.

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Propolis loaded liposomes: evaluation of antimicrobial and antioxidant activities

Cited by 37 publications

References 49 publications

Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products

Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products

Analytical Techniques for the Assessment of Drug-Lipid Interactions and the Active Substance Distribution in Liquid Dispersions of Solid Lipid Microparticles (SLM) Produced de novo and Reconstituted from Spray-Dried Powders

Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing

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