Propolis Components and Biological Activities from Stingless Bees Collected on South Sulawesi, Indonesia

Miyata, Ryo; Sahlan, Muhamad; Ishikawa, Yoshinobu; Hashimoto, Hiroshi; Honda, Sari; Kumazawa, Shigenori

doi:10.4308/hjb.27.1.82

Cited by 15 publications

(6 citation statements)

References 27 publications

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“…A total of 20 compounds from the propolis of stingless bees (Tetragonula sapiens), here termed as ligands, were obtained from Miyata et al (2020Miyata et al ( , 2019 publication and suggested from previous studies (Sahlan et al, 2019;Mahadewi et al, 2018). The information about selected compounds was tabulated in Table 1.…”

Section: Propolis Compounds Selectionmentioning

confidence: 99%

In Silico Identification of Propolis Compounds Potential as COVID-19 Drug Candidates Against SARS-CoV-2 Spike Protein

Sahlan¹,

Dewi²,

Pratami³

et al. 2023

IJTech

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Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2) is a global health issue resulting in mortality and morbidity across the world. There is an urgent need to find treatments to inhibit virus infections and their consequences. Propolis compounds are predicted to have interactions with the SARS-CoV-2 protein since it has various phytochemicals that have been used in medicine. Here, we conducted in silico study to analyze the interaction between propolis compounds and SARS-CoV-2 spike protein by performing molecular docking. The target protein of this research is the crystal structure of the SARS-CoV-2 spike receptor-binding domain (RBD) bound with ACE2 (PDB ID: 6M0J). The ligand of this study is the bioactive compounds from Propolis of Tetragonula sapiens. The docking analysis revealed that Broussoflavonol F and Glyasperin A were the most promising propolis compounds that potentially block the binding of the SARS-CoV-2 spike protein to the host ACE2 receptor, with the binding affinity of -7.6 kcal/mol and -7.3 kcal/mol and the geometric score of 4582 and 4382, respectively. Based on this finding, those compounds are the potential to be developed as COVID-19 drug candidates.

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Section: Propolis Compounds Selectionmentioning

confidence: 99%

In Silico Identification of Propolis Compounds Potential as COVID-19 Drug Candidates Against SARS-CoV-2 Spike Protein

Sahlan¹,

Dewi²,

Pratami³

et al. 2023

IJTech

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“…Terpenes of the carvacrol group can activate TRPA1 and TRPV3 ion channels, which mediate inflammatory pain. They can also inhibit COX-2, producing analgesic effects (Miyata et al, 2020).…”

Section: Pharmacological Effect Of Propolismentioning

confidence: 99%

Antimicrobial Properties of Tetragonula laeviceps Propolis for Methicillin-Resistant Staphylococcus Aureus: A Review

Sahasika Sri Bharata,

Budi Koendhori,

Nur Indiastuti

et al. 2023

IJRP

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Escalating use of antibiotics has led to the development of microbial resistance, exemplified by the emergence of methicillin-resistant Staphylococcus aureus (MRSA), which displays resistance to beta-lactam antibiotics, leading to skin infections, pneumonia, and bacteremia. The ramifications of such resistant bacterial infections, encompassing prolonged hospitalization, heightened treatment costs, and increased mortality rates, underscore the critical need for judicious management of "Drug of Choice" antibiotics to avert compromised sensitivity to MRSA. Effective resource management is imperative to address the MRSA threat. Propolis, a wax product renowned for its enriched antimicrobial properties attributed to terpenoids, saponins, alkaloids, and polyphenols, is derived from various bee species, with particular emphasis on Tetragonula laeviceps, the most widely distributed species in Southeast Asia. This literature review explores the potential of Tetragonula laeviceps propolis as an alternative treatment for MRSA infections. Recognizing the efficacy of propolis in combating antibiotic resistance holds valuable implications for future research and treatment strategies.

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“…Sulabiroin-A is a podophyllotoxin derivative recently isolated from propolis of the stingless bee Tetragonula aff. biroi , from South Sulawesi, Indonesia [ 142 ].…”

Section: Antiviral Activitymentioning

confidence: 99%

Perspectives for Uses of Propolis in Therapy against Infectious Diseases

Salatino

2022

Molecules

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Propolis has gained wide popularity over the last decades in several parts of the world. In parallel, the literature about propolis composition and biological properties increased markedly. A great number of papers have demonstrated that propolis from different parts of the world is composed mainly of phenolic substances, frequently flavonoids, derived from plant resins. Propolis has a relevant role in increasing the social immunity of bee hives. Experimental evidence indicates that propolis and its components have activity against bacteria, fungi, and viruses. Mechanisms of action on bacteria, fungi, and viruses are known for several propolis components. Experiments have shown that propolis may act synergistically with antibiotics, antifungals, and antivirus drugs, permitting the administration of lower doses of drugs and higher antimicrobial effects. The current trend of growing resistance of microbial pathogens to the available drugs has encouraged the introduction of propolis in therapy against infectious diseases. Because propolis composition is widely variable, standardized propolis extracts have been produced. Successful clinical trials have included propolis extracts as medicine in dentistry and as an adjuvant in the treatment of patients against COVID-19. Present world health conditions encourage initiatives toward the spread of the niche of propolis, not only as traditional and alternative medicine but also as a relevant protagonist in anti-infectious therapy. Production of propolis and other apiary products is environmentally friendly and may contribute to alleviating the current crisis of the decline of bee populations. Propolis production has had social-economic relevance in Brazil, providing benefits to underprivileged people.

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Propolis Components and Biological Activities from Stingless Bees Collected on South Sulawesi, Indonesia

Cited by 15 publications

References 27 publications

In Silico Identification of Propolis Compounds Potential as COVID-19 Drug Candidates Against SARS-CoV-2 Spike Protein

In Silico Identification of Propolis Compounds Potential as COVID-19 Drug Candidates Against SARS-CoV-2 Spike Protein

Antimicrobial Properties of Tetragonula laeviceps Propolis for Methicillin-Resistant Staphylococcus Aureus: A Review

Perspectives for Uses of Propolis in Therapy against Infectious Diseases

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