2023
DOI: 10.1590/1678-9199-jvatitd-2022-0044
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Abstract: Background: Propolis exhibits huge potential in the pharmaceutical industry. In the present study, its effects were investigated on dendritic cells (DCs) stimulated with a tumor antigen (MAGE-1) and retinoic acid (RA) and on T lymphocytes to observe a possible differential activation of T lymphocytes, driving preferentially to Th1 or Treg cells. Methods: Cell viability, lymphocyte proliferation, gene expression (T-bet and FoxP3), and cytokine production by DCs (TNF-α, I… Show more

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“…In vivo , DBA/1J mice with collagen-induced arthritis treated with propolis showed better scores than animals treated only with standard diet, as well as a decrease in the number of IL-17, IFN-γ, and IL-4 secretory cells, suggesting that propolis suppresses the differentiation of Th17 cells ( 34 ). Our findings are in agreement with those of Santiago et al ( 38 ), who reported that propolis affected Th1 responses and led naive T cells to a regulatory profile, reinforcing the potential use of propolis for the treatment of inflammatory conditions.…”
Section: Discussionsupporting
confidence: 93%
“…In vivo , DBA/1J mice with collagen-induced arthritis treated with propolis showed better scores than animals treated only with standard diet, as well as a decrease in the number of IL-17, IFN-γ, and IL-4 secretory cells, suggesting that propolis suppresses the differentiation of Th17 cells ( 34 ). Our findings are in agreement with those of Santiago et al ( 38 ), who reported that propolis affected Th1 responses and led naive T cells to a regulatory profile, reinforcing the potential use of propolis for the treatment of inflammatory conditions.…”
Section: Discussionsupporting
confidence: 93%