Propolis and the immune system: a review

Sforcin, José Maurício

doi:10.1016/j.jep.2007.05.012

Cited by 586 publications

(567 citation statements)

References 109 publications

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“…The inhibitory effect of propolis on lymphoproliferation might be associated with the production of regulatory cytokines such as IL-10 and TGF-β ( Sforcin, 2007), as well as the anti-inflammatory/ anti-angiogenic effects of propolis could be also associated with modulation of cytokine TGF-β1   Moura et al, 2011). Recent works has demonstrate that the propolis administration over a short-term to mice affected both basal and stimulated IFN-γ production, what may be related to its anti-inflammatory properties (Pagliarone et al, 2009;Orsatti et al, 2010;Missima et al, 2010).…”

Section: Anti-inflammatory and Immunomodulatory Response To Propolis mentioning

confidence: 99%

“…In fact, various biological properties have been demonstrated and attributed to different types of propolis, including antibacterial, antifungal, antiprotozoal, antioxidant, antitumor, anti-infl ammatory, anesthetic, wound healing, immunomodulatory, antiproliferative and anticariogenic activities (Dobrowolski et al, 1991;Ivanovska et al, 1995;Moura et al, 1999;Kujumgiev et al, 1999;Isla et al, 2001;Chen et al, 2004;Simões et al, 2004;Duran et al, 2006;Medic-Saric et al, 2009;Araujo et al, 2010;Sforcin, 2007;Libério et al, 2009;Pagliarone et al, 2009, Paulino et al, 2003.…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/ or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters), terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an antiinflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

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Section: Anti-inflammatory and Immunomodulatory Response To Propolis mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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“…This product has attracted researchers' interest in the last decade because of its numerous biological and pharmacological properties, such as antimicrobial (Sforcin et al, 2000;Freitas et al, 2006;Búfalo et al, 2009), antitumoral (Bazo et al, 2002), immunomodulatory (Sforcin, 2007), anti-inflammatory (Silva et al, 2012), antioxidant (Kumazawa et al, 2010), among others.…”

Section: Introductionmentioning

confidence: 99%

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Búfalo

Ferreira

Costa

et al. 2013

Journal of Ethnopharmacology

155

102

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Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages, Journal of Ethnopharmacology, http://dx.doi.org/ 10. 1016/j.jep.2013.06.004 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractEthnopharmacological relevance: Propolis is a bee product with numerous biological and pharmacological properties, such as immunomodulatory and anti-inflammatory activities.It has been used in folk medicine as a healthy drink and in food to improve health and prevent inflammatory diseases. However, little is known about its mechanism of action.Thus, the goal of this study was to verify the antioxidant activity and to explore the antiinflammatory properties of propolis by addressing its intracellular mechanism of action.Caffeic acid was investigated as a possible compound responsible for propolis action. Materials and Methods:The antioxidant properties of propolis and caffeic acid were evaluated by using the 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) scavenging method. To analyze the anti-inflammatory activity, Raw 264.7 macrophages were treated with different concentrations of propolis or caffeic acid, and nitric oxide (NO) production, a strong pro-inflammatory mediator, was evaluated by the Griess reaction. The concentrations of propolis and caffeic acid that inhibited NO production were evaluated on intracellular signaling pathways triggered during inflammation, namely p38 mitogenactivated protein kinase (MAPK), c-jun NH 2 -terminal kinase (JNK1/2), the transcription nuclear factor (NF)-NB and extracellular signal-regulated kinase (ERK1/2), through Western blot using specific antibodies. A possible effect of propolis on the cytotoxicity of hepatocytes was also evaluated, since this product can be used in human diets.Results: Caffeic acid showed a higher antioxidant activity than propolis extract. Propolis and caffeic acid inhibited NO production in macrophages, at concentrations without cytotoxicity. Furthermore, both propolis and caffeic acid suppressed LPS-induced signaling pathways, namely p38 MAPK, JNK1/2 and NF-NB. ERK1/2 was not affected by propolis extract and caffeic acid. In addition, propolis and caffeic acid did not induce hepatotoxicity at concentrations with strong anti-inflammatory potential. Conclusions:Propolis exerted an antioxidant and anti-inflammatory action and caffeic acid may be involved in its inhibitory effects on NO production and intracellular signaling cascades, suggesting its use as a natural source of safe anti-inflammatory drugs.

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“…In the bibliographical revisions was observed that several papers published in the international periodical and many patents also present data on the Brazilian propolis. [7][8][9] The use of propolis in the world is estimated at about 700-800 tonnes per year. 10 Insufficient official statistics on the volume of propolis produced in Brazil each year, which is exported and what is consumed by the domestic market.…”

Section: Introductionmentioning

confidence: 99%

Chiral Analysis of Monoterpenes in Volatile Oils From Propolis

Simionatto

Facco

Morel

et al. 2012

J. Chil. Chem. Soc.

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The essential oils obtained by hydrodistillation from samples of propolis manufactured in three regions of Rio Grande do Sul State at Brazil, were analyzed through CG, CG-MS and chiral phase gas chromatography (CPGC). These analyses display the presence of samples with elevated essential oil purport, when compared with plants. The yields obtained were until 3.8%. The samples exhibited similar composition, with predominance of the monoterpenes a-pinene (57-63%), b-pinene (12.5-30.8%) and limonene (1.5-11.2%). In chiral analysis of these constituents were observed modifications in the enantiomeric excess of isomers of a-pinene and limonene in relation with source location of the sample, already in the chiral analysis of b-pinene were detected only elevated excess of the enantiomer with the (-) configuration. The antimicrobial activity of the crude essential oil was assayed against five bacteria. The best result was obtained against Staphylococcus aureus.

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Propolis and the immune system: a review

Cited by 586 publications

References 109 publications

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-κB and MAPK activation in macrophages

Chiral Analysis of Monoterpenes in Volatile Oils From Propolis

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